STRINGSTRING
ANPEP ANPEP CD8A-3 CD8A-3 IFNA3 IFNA3 IL6 IL6 AGTR2 AGTR2 VEGFA VEGFA CD8A-2 CD8A-2 DPP4 DPP4 ENPEP ENPEP XPO1 XPO1 AR AR ACE2 ACE2 TMPRSS2 TMPRSS2 SLC6A19 SLC6A19 AGT AGT CTLA4 CTLA4 AXL AXL REN REN
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANPEPAminopeptidase Ey; Broad specificity aminopeptidase. Degrades a variety of peptides possessing various N-terminal amino acids including hydrophobic, basic and acidic amino acids. Preferentially hydrolyzes small peptides consisting of 4 or 5 amino acids. Hydrolyzes the N- terminal Xaa-Pro bonds in the chicken brain peptide Leu-Pro-Leu-Arg- PheNH2, the substance P fragment Arg-Pro-Lys-Pro and the bradykinin fragment Arg-Pro-Pro-Gly-Phe. Hydrolyzes the N-formylated peptides fMet-Leu-Phe, fMet-Ala-Gly-Ser-Glu and fMet-Nle-Leu-Phe-Nle-Tyr-Lys, but does not hydrolyze peptides with acetylatio [...] (972 aa)
CD8A-3Ig-like domain-containing protein. (318 aa)
IFNA3Interferon. (193 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
AGTR2Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (372 aa)
VEGFAVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). (674 aa)
CD8A-2Ig-like domain-containing protein. (235 aa)
DPP4Uncharacterized protein; Belongs to the peptidase S9B family. (760 aa)
ENPEPAminopeptidase. (943 aa)
XPO1Importin N-terminal domain-containing protein. (1071 aa)
ARUncharacterized protein. (703 aa)
ACE2Angiotensin-converting enzyme. (808 aa)
TMPRSS2Transmembrane serine protease 2; Belongs to the peptidase S1 family. (486 aa)
SLC6A19Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (636 aa)
AGTAngiotensinogen; Belongs to the serpin family. (464 aa)
CTLA4Cytotoxic T-lymphocyte-associated protein 4. (205 aa)
AXLTyrosine-protein kinase receptor TYRO3; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, enhances PI3- kinase activity and activates the AKT survival pathway, including nuclear translocation of NF-kappa-B [...] (873 aa)
RENRenin; Belongs to the peptidase A1 family. (423 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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