STRINGSTRING
IFIH1 IFIH1 CCL5 CCL5 TLR2A TLR2A MAVS MAVS TRIM25 TRIM25 AKT1 AKT1 TRAF3 TRAF3 MAP2K7 MAP2K7 CCL19 CCL19 TRAF6 TRAF6 TLR15 TLR15 IFNA3 IFNA3 JAK2 JAK2 PIK3R3 PIK3R3 DHX58 DHX58 LOC422993 LOC422993 LBP LBP NLRX1 NLRX1 TLR4 TLR4 TLR5 TLR5 TLR3 TLR3 AvBD10 AvBD10 AvBD8 AvBD8 AvBD1 AvBD1 IFNGR1 IFNGR1 AvBD12 AvBD12 AvBD11 AvBD11 AvBD7 AvBD7 TLR1A TLR1A AvBD3 AvBD3 AvBD9 AvBD9 JUN JUN IRF7 IRF7 FOS FOS TICAM1 TICAM1 SOCS3 SOCS3 LOC770612 LOC770612 CCL19-2 CCL19-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IFIH1Uncharacterized protein. (1102 aa)
CCL5C-C motif chemokine. (90 aa)
TLR2AToll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (955 aa)
MAVSCARD_2 domain-containing protein. (641 aa)
TRIM25Tripartite motif containing 25. (633 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
MAP2K7Mitogen-activated protein kinase kinase 7. (1088 aa)
CCL19C-C motif chemokine. (108 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
TLR15TIR domain-containing protein. (924 aa)
IFNA3Interferon. (193 aa)
JAK2Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recru [...] (1165 aa)
PIK3R3Uncharacterized protein. (463 aa)
DHX58Uncharacterized protein. (674 aa)
LOC422993Interferon-inducible transmembrane protein 1. (113 aa)
LBPUncharacterized protein. (481 aa)
NLRX1NLR family member X1. (990 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
TLR5TLR5; Belongs to the Toll-like receptor family. (861 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (896 aa)
AvBD10Gallinacin-10; Has bactericidal activity. (68 aa)
AvBD8Gallinacin-8; Has bactericidal activity. (66 aa)
AvBD1Gallinacin-1; Has bactericidal activity. Potent activity against E.coli ML- 35, L.monocytogenes EGD and C.albicans. (65 aa)
IFNGR1Uncharacterized protein. (442 aa)
AvBD12Gallinacin-12; Has bactericidal activity. (93 aa)
AvBD11Gallinacin-11; Has bactericidal activity. (104 aa)
AvBD7Gallinacin-7; Has bactericidal activity. (67 aa)
TLR1ATIR domain-containing protein; Belongs to the Toll-like receptor family. (818 aa)
AvBD3Gallinacin-3; Has bactericidal activity. (80 aa)
AvBD9Gallinacin-9; Has bactericidal activity. Potent activity against C.jejuni, C.perfringens, S.aureus, C.albicans and S.cerevisiae. Less potent against S.typhimurium and E.coli. (67 aa)
JUNTranscription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated KRAS-mediated transcriptional activation of USP28. May bind to the USP28 promoter; Belongs to the bZIP family. Jun subfamily. (310 aa)
IRF7Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the [...] (491 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. FOS has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, may activate phospholipid synthesis (By similarity). (367 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (735 aa)
SOCS3Suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin and leptin receptors (By similarity). Binding to JAK2 inhibits its kinase activity (By similarity). Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Regulates IL-6 [...] (209 aa)
LOC770612Uncharacterized protein. (137 aa)
CCL19-2SCY domain-containing protein. (99 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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