(8 nodes) (2023) Chlorpyrifos induces apoptosis and necroptosis via the activation of CYP450s pathway mediated by nuclear receptors in LMH cells. network (Gallus gallus)

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Your Input:
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (418 aa)
	MLKL	Mixed lineage kinase domain like pseudokinase. (486 aa)
	CASP8	Uncharacterized protein; Belongs to the peptidase C14A family. (482 aa)
	BCL2	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
	RIPK1	Uncharacterized protein. (682 aa)
	CASP18	Initiator caspase; Belongs to the peptidase C14A family. (464 aa)
	CASP3	Caspase-3; Belongs to the peptidase C14A family. (283 aa)
	RIPK3	Uncharacterized protein. (424 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL2	CASP18	ENSGALP00000020984	ENSGALP00000065273	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Initiator caspase; Belongs to the peptidase C14A family.	0.967
BCL2	CASP3	ENSGALP00000020984	ENSGALP00000068843	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Caspase-3; Belongs to the peptidase C14A family.	0.989
BCL2	CASP8	ENSGALP00000020984	ENSGALP00000013591	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Uncharacterized protein; Belongs to the peptidase C14A family.	0.967
BCL2	CASP9	ENSGALP00000020984	ENSGALP00000002083	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Caspase 9; Belongs to the peptidase C14A family.	0.984
BCL2	MLKL	ENSGALP00000020984	ENSGALP00000004360	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Mixed lineage kinase domain like pseudokinase.	0.456
BCL2	RIPK1	ENSGALP00000020984	ENSGALP00000036418	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Uncharacterized protein.	0.434
BCL2	RIPK3	ENSGALP00000020984	ENSGALP00000071292	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	Uncharacterized protein.	0.408
CASP18	BCL2	ENSGALP00000065273	ENSGALP00000020984	Initiator caspase; Belongs to the peptidase C14A family.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	0.967
CASP18	CASP3	ENSGALP00000065273	ENSGALP00000068843	Initiator caspase; Belongs to the peptidase C14A family.	Caspase-3; Belongs to the peptidase C14A family.	0.968
CASP18	CASP8	ENSGALP00000065273	ENSGALP00000013591	Initiator caspase; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.915
CASP18	CASP9	ENSGALP00000065273	ENSGALP00000002083	Initiator caspase; Belongs to the peptidase C14A family.	Caspase 9; Belongs to the peptidase C14A family.	0.508
CASP18	MLKL	ENSGALP00000065273	ENSGALP00000004360	Initiator caspase; Belongs to the peptidase C14A family.	Mixed lineage kinase domain like pseudokinase.	0.879
CASP18	RIPK1	ENSGALP00000065273	ENSGALP00000036418	Initiator caspase; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.993
CASP18	RIPK3	ENSGALP00000065273	ENSGALP00000071292	Initiator caspase; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.915
CASP3	BCL2	ENSGALP00000068843	ENSGALP00000020984	Caspase-3; Belongs to the peptidase C14A family.	Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).	0.989
CASP3	CASP18	ENSGALP00000068843	ENSGALP00000065273	Caspase-3; Belongs to the peptidase C14A family.	Initiator caspase; Belongs to the peptidase C14A family.	0.968
CASP3	CASP8	ENSGALP00000068843	ENSGALP00000013591	Caspase-3; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.968
CASP3	CASP9	ENSGALP00000068843	ENSGALP00000002083	Caspase-3; Belongs to the peptidase C14A family.	Caspase 9; Belongs to the peptidase C14A family.	0.987
CASP3	MLKL	ENSGALP00000068843	ENSGALP00000004360	Caspase-3; Belongs to the peptidase C14A family.	Mixed lineage kinase domain like pseudokinase.	0.718
CASP3	RIPK1	ENSGALP00000068843	ENSGALP00000036418	Caspase-3; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.887