STRINGSTRING
C1QTNF4 C1QTNF4 LOC771880-2 LOC771880-2 CD8A-3 CD8A-3 NTN3 NTN3 STEAP4 STEAP4 LOC112529934 LOC112529934 LOC107049937 LOC107049937 GPX4 GPX4 ENSGALP00000068753 ENSGALP00000068753 IL6 IL6 LOC107054704 LOC107054704 LOC107049158 LOC107049158 LOC107055470 LOC107055470 SCARB1 SCARB1 LOC112531454 LOC112531454 LOC107053306 LOC107053306 LOC771880 LOC771880 LOC771804 LOC771804 LOC107049200 LOC107049200 NDUFS4 NDUFS4 LOC100859100 LOC100859100 LOC417056 LOC417056 GPT2 GPT2 HBAD HBAD JAM2 JAM2 C1QC C1QC GLP1R GLP1R NOV NOV HBA1 HBA1 BTN1A1 BTN1A1 CXCL12 CXCL12 CCN3 CCN3 LOC395611 LOC395611 LOC112532337 LOC112532337 EGF EGF EXFABP EXFABP COX7C COX7C IL4 IL4 SOCS3 SOCS3 NTN1 NTN1 AvBD9 AvBD9 HBBA HBBA BDKRB1 BDKRB1 AvBD10 AvBD10 GSTA2 GSTA2 GSTA4 GSTA4 ENPP7 ENPP7 LCT LCT SOD2 SOD2 HPGDS HPGDS IL10 IL10 CYP1A2 CYP1A2 BCO1 BCO1 GJB1 GJB1 CPO CPO PDK4 PDK4 IFNG IFNG IL22 IL22 GBP1 GBP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
C1QTNF4C1q and TNF related 4. (375 aa)
LOC771880-2Ig-like domain-containing protein. (214 aa)
CD8A-3Ig-like domain-containing protein. (318 aa)
NTN3Netrin-3; Netrins control guidance of CNS commissural axons and peripheral motor axons. (644 aa)
STEAP4STEAP4 metalloreductase. (472 aa)
LOC112529934Ig-like domain-containing protein. (198 aa)
LOC107049937Uncharacterized protein. (608 aa)
GPX4Glutathione peroxidase; Belongs to the glutathione peroxidase family. (186 aa)
ENSGALP00000068753Ig-like domain-containing protein. (159 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
LOC107054704Ig-like domain-containing protein; Belongs to the MHC class I family. (483 aa)
LOC107049158Ig-like domain-containing protein. (245 aa)
LOC107055470B30.2/SPRY domain-containing protein. (191 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (503 aa)
LOC112531454GB1/RHD3-type G domain-containing protein. (194 aa)
LOC107053306Ig-like domain-containing protein. (212 aa)
LOC771880Ig-like domain-containing protein. (228 aa)
LOC771804Ig-like domain-containing protein. (241 aa)
LOC107049200Ig-like domain-containing protein. (155 aa)
NDUFS4NADH:ubiquinone oxidoreductase subunit S4. (294 aa)
LOC100859100Ig-like domain-containing protein; Belongs to the MHC class I family. (450 aa)
LOC417056Ig-like domain-containing protein; Belongs to the MHC class I family. (392 aa)
GPT2Glutamic--pyruvic transaminase 2. (544 aa)
HBADHemoglobin subunit alpha-D; Involved in oxygen transport from the lung to the various peripheral tissues. (141 aa)
JAM2Uncharacterized protein. (295 aa)
C1QCComplement C1q C chain. (245 aa)
GLP1RGlucagon-like peptide 1 receptor; Belongs to the G-protein coupled receptor 2 family. (459 aa)
NOVCTCK domain-containing protein. (360 aa)
HBA1Hemoglobin subunit alpha-A; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (142 aa)
BTN1A1Uncharacterized protein. (514 aa)
CXCL12SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (167 aa)
CCN3CCN family member 3; Immediate-early protein likely to play a role in cell growth regulation. Its overexpression is associated with tumorigenesis and expression of a N-terminal-truncated version of CCN3 gene in chicken embryonic fibroblasts (CEF) is sufficient to induce the transformation of CEF in vitro. (351 aa)
LOC395611Uncharacterized protein; Belongs to the GST superfamily. (221 aa)
LOC112532337Ig-like domain-containing protein. (215 aa)
EGFUncharacterized protein. (1283 aa)
EXFABPExtracellular fatty acid-binding protein; Siderocalin-like lipocalin tightly binding a variety of bacterial ferric siderophores, also binds long-chain unsaturated fatty acids such as linoleic acid, oleic acid, arachidonic acid and, with a lower affinity, long chain saturated fatty acids such as steraic acid. May act as an antibacterial factor, through dual ligand specificity, both as a siderophore-sequestrating molecule and a lysophosphatidic acid (LPA) sensor; Belongs to the calycin superfamily. Lipocalin family. (178 aa)
COX7CCytochrome c oxidase subunit 7C. (140 aa)
IL4Interleukin 4. (136 aa)
SOCS3Suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin and leptin receptors (By similarity). Binding to JAK2 inhibits its kinase activity (By similarity). Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Regulates IL-6 [...] (209 aa)
NTN1Netrin-1; Netrins control guidance of CNS commissural axons and peripheral motor axons. Promotes neurite outgrowth from commissural axons but acts as a chemorepellent for trochlear motor axons. These effects are mediated by distinct receptors. (688 aa)
AvBD9Gallinacin-9; Has bactericidal activity. Potent activity against C.jejuni, C.perfringens, S.aureus, C.albicans and S.cerevisiae. Less potent against S.typhimurium and E.coli. (67 aa)
HBBAHemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. The beta chain is a component of adult hemoglobin A and D. (147 aa)
BDKRB1Bradykinin receptor B1. (358 aa)
AvBD10Gallinacin-10; Has bactericidal activity. (68 aa)
GSTA2Glutathione S-transferase; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Alpha family. (222 aa)
GSTA4Glutathione S-transferase class-alpha. (223 aa)
ENPP7Ectonucleotide pyrophosphatase/phosphodiesterase 7. (444 aa)
LCTUncharacterized protein. (1935 aa)
SOD2Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
HPGDSHematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides, organic isothiocyanates and alpha,beta-unsaturated carbonyls. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide and t-butyl hydroperoxide. (199 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa)
CYP1A2Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa)
BCO1Beta,beta-carotene 15,15'-dioxygenase; Symmetrically cleaves beta-carotene into two molecules of retinal using a dioxygenase mechanism; Belongs to the carotenoid oxygenase family. (526 aa)
GJB1Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (279 aa)
CPOCarboxypeptidase O. (379 aa)
PDK4Protein-serine/threonine kinase. (414 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (164 aa)
IL22Uncharacterized protein. (197 aa)
GBP1GB1/RHD3-type G domain-containing protein. (1020 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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