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SPRY3 SPRY3 SLC25A5 SLC25A5 SLC25A43 SLC25A43 SLC16A7 SLC16A7 KITLG KITLG IRF4 IRF4 OCA2 OCA2 TYR TYR UCP3 UCP3 EDNRB EDNRB DCT DCT SLC25A6 SLC25A6 TYRP1 TYRP1 SLC25A20 SLC25A20 FOXP1 FOXP1 TAFA4 TAFA4 POU4F3 POU4F3 COL3A1 COL3A1 HSPG2 HSPG2 SLC25A14 SLC25A14 LGALS3 LGALS3 POU4F3-2 POU4F3-2 GAPDH GAPDH SLC25A26 SLC25A26 P4HB P4HB MITF MITF TAFA1 TAFA1 TMLHE TMLHE MYC MYC EDNRB2 EDNRB2 IRF1 IRF1 USF1 USF1 SLC45A2 SLC45A2 USP3 USP3 BMP15 BMP15 ACOX2 ACOX2 FAM107A FAM107A SYP SYP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPRY3Sprouty-like protein 3. (291 aa)
SLC25A5Solute carrier family 25 member 5; Belongs to the mitochondrial carrier (TC 2.A.29) family. (389 aa)
SLC25A43Solute carrier family 25 member 43; Belongs to the mitochondrial carrier (TC 2.A.29) family. (339 aa)
SLC16A7MFS domain-containing protein. (480 aa)
KITLGProcessed kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Acts synergistically with other cytokines, probably interleukins (By similarity). (287 aa)
IRF4Interferon regulatory factor 4. (445 aa)
OCA2OCA2 melanosomal transmembrane protein. (726 aa)
TYRTyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. (537 aa)
UCP3Mitochondrial uncoupling protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (307 aa)
EDNRBG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (560 aa)
DCTL-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. (521 aa)
SLC25A6Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (298 aa)
TYRP15,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. (536 aa)
SLC25A20Solute carrier family 25 member 20; Belongs to the mitochondrial carrier (TC 2.A.29) family. (301 aa)
FOXP1Forkhead box protein P1; Transcriptional repressor. (686 aa)
TAFA4TAFA chemokine like family member 4. (173 aa)
POU4F3POU domain protein. (326 aa)
COL3A1Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. (1460 aa)
HSPG2Heparan sulfate proteoglycan 2. (3948 aa)
SLC25A14Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (484 aa)
LGALS3Galectin. (258 aa)
POU4F3-2Brain-specific homeobox/POU domain protein 3; May play a role in specifying terminally differentiated neuronal phenotypes; Belongs to the POU transcription factor family. Class-4 subfamily. (341 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
SLC25A26Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (328 aa)
P4HBProtein disulfide-isomerase; This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). Also acts a structural subunit o [...] (547 aa)
MITFBHLH domain-containing protein. (519 aa)
TAFA1TAFA chemokine like family member 1. (145 aa)
TMLHETrimethyllysine dioxygenase, mitochondrial; Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML). (418 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (429 aa)
EDNRB2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (479 aa)
IRF1Interferon regulatory factor 1; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor (By similarity); Belongs to the IRF family. (414 aa)
USF1BHLH domain-containing protein. (614 aa)
SLC45A2Uncharacterized protein. (543 aa)
USP3Ubiquitin carboxyl-terminal hydrolase. (520 aa)
BMP15TGF_BETA_2 domain-containing protein. (350 aa)
ACOX2Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (675 aa)
FAM107AFamily with sequence similarity 107 member A. (175 aa)
SYPMARVEL domain-containing protein. (338 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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