30 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CUL1	Cullin 1; Belongs to the cullin family. (776 aa)
	CUL4B	Cullin 4B; Belongs to the cullin family. (883 aa)
	GRIP2	Glutamate receptor interacting protein 2. (1104 aa)
	CEP192	Centrosomal protein 192. (2540 aa)
	CDK2	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
	BRSK1	Protein kinase domain-containing protein. (802 aa)
	NME7	Nucleoside diphosphate kinase 7; Belongs to the NDK family. (377 aa)
	AKAP9	Uncharacterized protein. (3963 aa)
	GIT1	ANK_REP_REGION domain-containing protein. (791 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (429 aa)
	RAD51	DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. (339 aa)
	TUBG1	Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. (452 aa)
	CDK5RAP3	Uncharacterized protein. (619 aa)
	BRCA1	Uncharacterized protein. (1749 aa)
	CDK1	Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle (By similarity). It is required in higher cells for entry into S-phase and mitosis (By similarity). p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). May play a role in regulating the amplitude of the cyclic expression of circadian clock genes (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (303 aa)
	BARD1	Uncharacterized protein. (795 aa)
	BAP1	Ubiquitin carboxyl-terminal hydrolase BAP1; Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity); Belongs to the peptidase C12 family. BAP1 subfamily. (751 aa)
	SASS6	Spindle assembly abnormal protein 6 homolog; Central scaffolding component of the centrioles ensuring their 9-fold symmetry. Required for centrosome biogenesis and duplication: required both for mother-centriole-dependent centriole duplication and deuterosome-dependent centriole amplification in multiciliated cells (By similarity). (640 aa)
	PLK1	Serine/threonine-protein kinase PLK. (595 aa)
	TPX2	Uncharacterized protein. (738 aa)
	PCNT	Pericentrin. (3492 aa)
	ELMOD2	ELMO domain-containing protein. (297 aa)
	PLK4	POLO box domain-containing protein. (566 aa)
	NIN	Ninein. (2081 aa)
	POC5	Uncharacterized protein. (576 aa)
	TACC3	TACC_C domain-containing protein. (891 aa)
	CUL4A	Cullin 4A; Belongs to the cullin family. (767 aa)
	MZT1	Uncharacterized protein. (89 aa)
	WRAP73	Uncharacterized protein. (449 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKAP9	GRIP2	ENSGALP00000068569	ENSGALP00000050261	Uncharacterized protein.	Glutamate receptor interacting protein 2.	0.532
AKAP9	PLK1	ENSGALP00000068569	ENSGALP00000009850	Uncharacterized protein.	Serine/threonine-protein kinase PLK.	0.838
AKAP9	TPX2	ENSGALP00000068569	ENSGALP00000010115	Uncharacterized protein.	Uncharacterized protein.	0.574
AKAP9	TUBG1	ENSGALP00000068569	ENSGALP00000043891	Uncharacterized protein.	Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome.	0.434
BAP1	BARD1	ENSGALP00000006954	ENSGALP00000005502	Ubiquitin carboxyl-terminal hydrolase BAP1; Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity); Belongs to the peptidase C12 family. BAP1 subfamily.	Uncharacterized protein.	0.973
BAP1	BRCA1	ENSGALP00000006954	ENSGALP00000004383	Ubiquitin carboxyl-terminal hydrolase BAP1; Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity); Belongs to the peptidase C12 family. BAP1 subfamily.	Uncharacterized protein.	0.902
BARD1	BAP1	ENSGALP00000005502	ENSGALP00000006954	Uncharacterized protein.	Ubiquitin carboxyl-terminal hydrolase BAP1; Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity); Belongs to the peptidase C12 family. BAP1 subfamily.	0.973
BARD1	BRCA1	ENSGALP00000005502	ENSGALP00000004383	Uncharacterized protein.	Uncharacterized protein.	0.999
BARD1	CDK1	ENSGALP00000005502	ENSGALP00000004867	Uncharacterized protein.	Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle (By similarity). It is required in higher cells for entry into S-phase and mitosis (By similarity). p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). May play a role in regulating the amplitude of the cyclic expression of circadian clock genes (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	0.551
BARD1	CDK2	ENSGALP00000005502	ENSGALP00000056613	Uncharacterized protein.	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.477
BARD1	PCNA	ENSGALP00000005502	ENSGALP00000064149	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.539
BARD1	PLK1	ENSGALP00000005502	ENSGALP00000009850	Uncharacterized protein.	Serine/threonine-protein kinase PLK.	0.551
BARD1	PLK4	ENSGALP00000005502	ENSGALP00000016553	Uncharacterized protein.	POLO box domain-containing protein.	0.414
BARD1	RAD51	ENSGALP00000005502	ENSGALP00000046453	Uncharacterized protein.	DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange.	0.966
BARD1	TPX2	ENSGALP00000005502	ENSGALP00000010115	Uncharacterized protein.	Uncharacterized protein.	0.403
BARD1	TUBG1	ENSGALP00000005502	ENSGALP00000043891	Uncharacterized protein.	Tubulin gamma chain; Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome.	0.497
BRCA1	BAP1	ENSGALP00000004383	ENSGALP00000006954	Uncharacterized protein.	Ubiquitin carboxyl-terminal hydrolase BAP1; Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) (By similarity); Belongs to the peptidase C12 family. BAP1 subfamily.	0.902
BRCA1	BARD1	ENSGALP00000004383	ENSGALP00000005502	Uncharacterized protein.	Uncharacterized protein.	0.999
BRCA1	CDK1	ENSGALP00000004383	ENSGALP00000004867	Uncharacterized protein.	Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle (By similarity). It is required in higher cells for entry into S-phase and mitosis (By similarity). p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). May play a role in regulating the amplitude of the cyclic expression of circadian clock genes (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.	0.803
BRCA1	CDK2	ENSGALP00000004383	ENSGALP00000056613	Uncharacterized protein.	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.741