(63 nodes) (2022) Generation of mitochondria-rich kidney organoids from expandable intermediate mesoderm progenitors reprogrammed from human urine cells under defined medium. network (Gallus gallus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	GATA3	GATA-binding factor 3; Transcriptional activator which probably serves as a general switch factor for cell-specific development. It binds to DNA sites with the consensus sequence 5'-[AT]GATA[AG]-3' within regulatory regions of genes. (444 aa)
	PLP1	Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin; Belongs to the myelin proteolipid protein family. (277 aa)
	REN	Renin; Belongs to the peptidase A1 family. (423 aa)
	NPHS2	NPHS2 stomatin family member, podocin. (384 aa)
	SLC12A1	Solute carrier family 12 member 1. (1097 aa)
	LHX1	LIM/homeobox protein Lhx1; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with ISL-2. (406 aa)
	TBX6	T-box-containing protein TBX6L; May be involved in regulating somitogenesis. (452 aa)
	CUBN	Cubilin. (3634 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1216 aa)
	SFRP2	Secreted frizzled-related protein 2; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 appears to be associated with myogenesis. (292 aa)
	BNIP3	BCL2 interacting protein 3. (155 aa)
	LRP2	LDL receptor related protein 2. (3187 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (464 aa)
	SLC25A3	Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (358 aa)
	WT1	Uncharacterized protein. (417 aa)
	BMP4	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. (404 aa)
	COX5A	Cytochrome c oxidase subunit 5A. (140 aa)
	CLDN10	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (228 aa)
	CDH6	Cadherin-6; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. (790 aa)
	FGF2	Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family. (158 aa)
	HBBA	Hemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. The beta chain is a component of adult hemoglobin A and D. (147 aa)
	PTPRO	Uncharacterized protein. (1268 aa)
	SLC12A2	Solute carrier family 12 member 2. (1150 aa)
	AMBRA1	Autophagy and beclin 1 regulator 1. (872 aa)
	LDHA	L-lactate dehydrogenase A chain; Belongs to the LDH/MDH superfamily. LDH family. (332 aa)
	EEF1AKMT4	EEF1A lysine methyltransferase 4. (248 aa)
	KLF4	Uncharacterized protein. (111 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
	UBE2C	Ubiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
	SIX2	Sine oculis-related homeobox 2 homolog. (287 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (711 aa)
	ALB	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. (565 aa)
	SOX17	Uncharacterized protein. (410 aa)
	FOXA2	Fork-head domain-containing protein. (438 aa)
	EGF	Uncharacterized protein. (1283 aa)
	TBX3	T-box transcription factor TBX3; Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation. (732 aa)
	PAX2	Paired-box containing protein Pax-2. (394 aa)
	SOX2	Transcription factor SOX-2; Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development. (312 aa)
	SLC14A2	Urea transporter; Belongs to the urea transporter family. (426 aa)
	HOXD11	Homeobox protein Hox-D11; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. (280 aa)
	KIAA0101	PAF domain-containing protein. (110 aa)
	FOXF1	Forkhead box F1. (407 aa)
	SLC2A1	Solute carrier family 2, facilitated glucose transporter member 1; Facilitative glucose transporter, which is responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. Most important energy carrier of the brain: present at the blood-brain barrier and assures the energy-independent, facilitative transport of glucose into the brain. (490 aa)
	ATP5MC1	ATP synthase membrane subunit c locus 1; Belongs to the ATPase C chain family. (136 aa)
	PKLR	Pyruvate kinase PKM; Plays a key role in glycolysis; Belongs to the pyruvate kinase family. (550 aa)
	SOX1	Transcription factor SOX-1; Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural protein and suppresses neuronal differentiation. (373 aa)
	SURF1	Surfeit locus protein 1; May play a role in mitochondrial respiratory chain complex IV assembly. Probably involved in the biogenesis of the COX complex. Belongs to the SURF1 family. (309 aa)
	COL2A1	Collagen alpha-1(II) chain; Type II collagen is specific for cartilaginous tissues. It is essential for the normal embryonic development of the skeleton, for linear growth and for the ability of cartilage to resist compressive forces. (1420 aa)
	IRX1	Homeobox domain-containing protein. (467 aa)
	MRPL48	Ribosomal_S10 domain-containing protein. (209 aa)
	CALB1	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. (262 aa)
	CLIC5	Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (389 aa)
	PRCP	Prolylcarboxypeptidase. (483 aa)
	SLC25A1	Solute carrier family 25 member 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (310 aa)
	SLC14A2-2	Urea transporter; Belongs to the urea transporter family. (389 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
	MKI67	FHA domain-containing protein. (2570 aa)
	KLF-4	Uncharacterized protein. (481 aa)
	GDF15	TGF_BETA_2 domain-containing protein. (614 aa)
	SUSD3	Sushi domain containing 3. (312 aa)
	PAX6	Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development. (500 aa)
	PODXL	Podocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro- adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubul [...] (589 aa)
	ATG13	Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (540 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGT	ALB	ENSGALP00000018089	ENSGALP00000044604	Angiotensinogen; Belongs to the serpin family.	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	0.511
AGT	REN	ENSGALP00000018089	ENSGALP00000000756	Angiotensinogen; Belongs to the serpin family.	Renin; Belongs to the peptidase A1 family.	0.975
AGT	SLC14A2	ENSGALP00000018089	ENSGALP00000045555	Angiotensinogen; Belongs to the serpin family.	Urea transporter; Belongs to the urea transporter family.	0.445
AGT	SLC14A2-2	ENSGALP00000018089	ENSGALP00000057881	Angiotensinogen; Belongs to the serpin family.	Urea transporter; Belongs to the urea transporter family.	0.437
ALB	AGT	ENSGALP00000044604	ENSGALP00000018089	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Angiotensinogen; Belongs to the serpin family.	0.511
ALB	BMP4	ENSGALP00000044604	ENSGALP00000020289	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge.	0.615
ALB	CALB1	ENSGALP00000044604	ENSGALP00000056213	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.	0.677
ALB	CUBN	ENSGALP00000044604	ENSGALP00000014150	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Cubilin.	0.794
ALB	EGF	ENSGALP00000044604	ENSGALP00000044972	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Uncharacterized protein.	0.844
ALB	FGF2	ENSGALP00000044604	ENSGALP00000031519	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family.	0.844
ALB	FGF9	ENSGALP00000044604	ENSGALP00000041598	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.626
ALB	FOXA2	ENSGALP00000044604	ENSGALP00000044955	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Fork-head domain-containing protein.	0.553
ALB	GAPDH	ENSGALP00000044604	ENSGALP00000063325	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...]	0.954
ALB	KLF-4	ENSGALP00000044604	ENSGALP00000065832	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Uncharacterized protein.	0.427
ALB	KLF4	ENSGALP00000044604	ENSGALP00000041546	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Uncharacterized protein.	0.430
ALB	NPHS2	ENSGALP00000044604	ENSGALP00000006610	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	NPHS2 stomatin family member, podocin.	0.521
ALB	PAX6	ENSGALP00000044604	ENSGALP00000070449	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development.	0.588
ALB	REN	ENSGALP00000044604	ENSGALP00000000756	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Renin; Belongs to the peptidase A1 family.	0.618
ALB	SOX17	ENSGALP00000044604	ENSGALP00000044808	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Uncharacterized protein.	0.491
ALB	SOX2	ENSGALP00000044604	ENSGALP00000045318	Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family.	Transcription factor SOX-2; Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development.	0.626