(25 nodes) (2022) Age-related Huntingtons disease progression modeled in directly reprogrammed patient-derived striatal neurons highlights impaired autophagy. network (Gallus gallus)

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	DLX1	Homeodomain transcription factor DLX1. (255 aa)
	STAT3	Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes. (771 aa)
	BECN1	Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family. (447 aa)
	SIRT1	Deacetylase sirtuin-type domain-containing protein. (881 aa)
	ATG16L1	Autophagy related 16 like 1. (623 aa)
	BDNF	Brain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (254 aa)
	CDKN1A	Uncharacterized protein. (319 aa)
	PPP1R1B	Uncharacterized protein. (438 aa)
	CASP3	Caspase-3; Belongs to the peptidase C14A family. (283 aa)
	PIK3R1	Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
	SMAD3	Mothers against decapentaplegic homolog 3; Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor- regulated SMAD (R-SMAD) (By similarity). (426 aa)
	FOXO1	Fork-head domain-containing protein. (727 aa)
	ANXA5	Annexin A5; Collagen-binding protein. (321 aa)
	BCL2L1	Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity). (229 aa)
	DLX2	Distal-less homeobox 2. (253 aa)
	ATG7	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (709 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (288 aa)
	PXDNL	Uncharacterized protein. (1406 aa)
	TWIST1	CTwist. (190 aa)
	ATG10	Autophagy related 10. (227 aa)
	RAB8A	Ras-related protein Rab-8A; May be involved in vesicular trafficking and neurotransmitter release; Belongs to the small GTPase superfamily. Rab family. (207 aa)
	FOS	Proto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. FOS has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, may activate phospholipid synthesis (By similarity). (367 aa)
	PXDN	Peroxidasin. (1611 aa)
	MYT1L	Myelin transcription factor 1 like. (1190 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA5	ATG5	ENSGALP00000055261	ENSGALP00000050539	Annexin A5; Collagen-binding protein.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.478
ANXA5	ATG7	ENSGALP00000055261	ENSGALP00000051055	Annexin A5; Collagen-binding protein.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.423
ANXA5	BCL2L1	ENSGALP00000055261	ENSGALP00000054103	Annexin A5; Collagen-binding protein.	Bcl-2-like protein 1; Dominant regulator of apoptotic cell death. The long form displays cell death repressor activity, whereas the short isoform promotes apoptosis. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis (By similarity).	0.759
ANXA5	BECN1	ENSGALP00000055261	ENSGALP00000004697	Annexin A5; Collagen-binding protein.	Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family.	0.498
ANXA5	CASP3	ENSGALP00000055261	ENSGALP00000068843	Annexin A5; Collagen-binding protein.	Caspase-3; Belongs to the peptidase C14A family.	0.960
ANXA5	GAPDH	ENSGALP00000055261	ENSGALP00000063325	Annexin A5; Collagen-binding protein.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...]	0.801
ANXA5	PXDN	ENSGALP00000055261	ENSGALP00000026363	Annexin A5; Collagen-binding protein.	Peroxidasin.	0.774
ANXA5	PXDNL	ENSGALP00000055261	ENSGALP00000049777	Annexin A5; Collagen-binding protein.	Uncharacterized protein.	0.774
ANXA5	STAT3	ENSGALP00000055261	ENSGALP00000005161	Annexin A5; Collagen-binding protein.	Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes.	0.592
ATG10	ATG16L1	ENSGALP00000042565	ENSGALP00000002472	Autophagy related 10.	Autophagy related 16 like 1.	0.960
ATG10	ATG5	ENSGALP00000042565	ENSGALP00000050539	Autophagy related 10.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.980
ATG10	ATG7	ENSGALP00000042565	ENSGALP00000051055	Autophagy related 10.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.990
ATG10	BECN1	ENSGALP00000042565	ENSGALP00000004697	Autophagy related 10.	Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family.	0.901
ATG16L1	ATG10	ENSGALP00000002472	ENSGALP00000042565	Autophagy related 16 like 1.	Autophagy related 10.	0.960
ATG16L1	ATG5	ENSGALP00000002472	ENSGALP00000050539	Autophagy related 16 like 1.	Autophagy protein 5; Involved in autophagic vesicle formation.	0.999
ATG16L1	ATG7	ENSGALP00000002472	ENSGALP00000051055	Autophagy related 16 like 1.	Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...]	0.979
ATG16L1	BECN1	ENSGALP00000002472	ENSGALP00000004697	Autophagy related 16 like 1.	Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family.	0.966
ATG5	ANXA5	ENSGALP00000050539	ENSGALP00000055261	Autophagy protein 5; Involved in autophagic vesicle formation.	Annexin A5; Collagen-binding protein.	0.478
ATG5	ATG10	ENSGALP00000050539	ENSGALP00000042565	Autophagy protein 5; Involved in autophagic vesicle formation.	Autophagy related 10.	0.980
ATG5	ATG16L1	ENSGALP00000050539	ENSGALP00000002472	Autophagy protein 5; Involved in autophagic vesicle formation.	Autophagy related 16 like 1.	0.999