STRINGSTRING
CALB1 CALB1 NTM NTM AGRP AGRP NPTX2 NPTX2 NTNG2 NTNG2 GPX3 GPX3 SHH SHH FEZF2 FEZF2 SST SST IRS4 IRS4 LHX5 LHX5 TRH TRH DLX5 DLX5 FOXP2 FOXP2 CHRM3 CHRM3 DLK1 DLK1 HCRT HCRT PMCH PMCH PLAGL1 PLAGL1 SIM1 SIM1 PNOC PNOC PARM1 PARM1 ERBB4 ERBB4 NEK7 NEK7 TCF3 TCF3 NTS NTS OTP OTP S100A10 S100A10 CALB2 CALB2 GAL GAL SATB2 SATB2 LHX6 LHX6 PITX2 PITX2 TRHR TRHR TBR1 TBR1 GLI1 GLI1 CRH CRH CBLN3 CBLN3 TH TH EBF3 EBF3 WIF1 WIF1 GAD1 GAD1 ECEL1 ECEL1 SLC32A1 SLC32A1 FOXG1 FOXG1 GAD2 GAD2 NKX2-1 NKX2-1 SLC17A6 SLC17A6 BARHL2 BARHL2 BCL11B BCL11B NOS1 NOS1 ZIC5 ZIC5 MEIS2 MEIS2 TAC1 TAC1 RFX4 RFX4 MDGA1 MDGA1 LHX9 LHX9 CACNA2D1 CACNA2D1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CALB1Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. (262 aa)
NTMProtein CEPU-1; It may be a cellular address molecule specific to Purkinje cells. It may represent a receptor or a subunit of a receptor complex; Belongs to the immunoglobulin superfamily. IgLON family. (437 aa)
AGRPAgouti-related protein. (233 aa)
NPTX2Neuronal pentraxin 2. (434 aa)
NTNG2Netrin G2. (527 aa)
GPX3Uncharacterized protein. (208 aa)
SHHSonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (425 aa)
FEZF2FEZ family zinc finger 2. (441 aa)
SSTSomatostatin-14; Somatostatin inhibits the release of somatotropin. (116 aa)
IRS4Insulin receptor substrate 4. (1164 aa)
LHX5LIM homeobox protein 5. (402 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems; Belongs to the TRH family. (260 aa)
DLX5Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. (286 aa)
FOXP2Fork-head domain-containing protein. (513 aa)
CHRM3Muscarinic acetylcholine receptor M3; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. (639 aa)
DLK1DLK1. (386 aa)
HCRTUncharacterized protein. (148 aa)
PMCHPMCH. (163 aa)
PLAGL1PLAG1 like zinc finger 1. (776 aa)
SIM1SIM bHLH transcription factor 1. (766 aa)
PNOCUncharacterized protein. (194 aa)
PARM1Prostate androgen-regulated mucin-like protein 1. (284 aa)
ERBB4Receptor protein-tyrosine kinase. (1276 aa)
NEK7Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (302 aa)
TCF3BHLH domain-containing protein. (682 aa)
NTSNeurotensin. (164 aa)
OTPOrthopedia homeobox. (325 aa)
S100A10Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. (97 aa)
CALB2Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons. (311 aa)
GALGalanin variant 1. (141 aa)
SATB2DNA-binding protein SATB. (731 aa)
LHX6LIM homeobox 6. (380 aa)
PITX2Pituitary homeobox 2; May play an important role in development and maintenance of anterior structures. May play a role in determining left-right asymmetry and in vasculogenesis during avian embryogenesis. (333 aa)
TRHRThyrotropin-releasing hormone receptor; Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (395 aa)
TBR1T-box brain transcription factor 1. (677 aa)
GLI1Zinc finger protein GLI1; Acts as a transcriptional activator. Binds to the DNA consensus sequence 5'-GACCACCCA-3' (By similarity). May regulate the transcription of specific genes during normal development. May play a role in craniofacial development and digital development, as well as development of the central nervous system and gastrointestinal tract. Mediates SHH signaling. Plays a role in cell proliferation and differentiation via its role in SHH signaling. Belongs to the GLI C2H2-type zinc-finger protein family. (1281 aa)
CRHCorticotropin releasing hormone. (167 aa)
CBLN3C1q domain-containing protein. (196 aa)
THTyrosine hydroxylase. (491 aa)
EBF3EBF transcription factor 3. (596 aa)
WIF1Uncharacterized protein. (374 aa)
GAD1Glutamate decarboxylase 67. (590 aa)
ECEL1Endothelin converting enzyme like 1. (763 aa)
SLC32A1Solute carrier family 32 member 1. (521 aa)
FOXG1Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes. (451 aa)
GAD2Glutamate decarboxylase 2. (807 aa)
NKX2-1Homeobox domain-containing protein. (345 aa)
SLC17A6MFS domain-containing protein. (585 aa)
BARHL2BarH like homeobox 2. (369 aa)
BCL11BBAF chromatin remodeling complex subunit BCL11B. (884 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1435 aa)
ZIC5Zic family member 5. (495 aa)
MEIS2Homeoprotein Meis2a.2. (394 aa)
TAC1Tachykinin precursor 1. (114 aa)
RFX4Regulatory factor X4. (743 aa)
MDGA1MAM domain-containing glycosylphosphatidylinositol anchor protein 1; Required for radial migration of cortical neurons in the superficial layer of the neocortex. (1009 aa)
LHX9LIM/homeobox protein Lhx9; May be involved in gonadal development. (455 aa)
CACNA2D1VWFA domain-containing protein. (1155 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.