13 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
	CYP3A4	Uncharacterized protein; Belongs to the cytochrome P450 family. (540 aa)
	CYP3A5	Uncharacterized protein. (508 aa)
	INS	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (164 aa)
	NR1H4	Farnesoid X receptor. (473 aa)
	SOD2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
	MB	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. (154 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (267 aa)
	COL3A1	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. (1460 aa)
	CYP7A1	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (513 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
	SLCO1B3	Solute carrier organic anion transporter family member. (722 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COL3A1	GAPDH	ENSGALP00000051057	ENSGALP00000063325	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...]	0.888
COL3A1	IFNG	ENSGALP00000051057	ENSGALP00000016086	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	0.711
COL3A1	IL1B	ENSGALP00000051057	ENSGALP00000050171	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	Interleukin-1; Belongs to the IL-1 family.	0.860
COL3A1	IL6	ENSGALP00000051057	ENSGALP00000068117	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.866
COL3A1	INS	ENSGALP00000051057	ENSGALP00000010567	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.861
COL3A1	MB	ENSGALP00000051057	ENSGALP00000020457	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles.	0.704
CYP3A4	CYP3A5	ENSGALP00000007048	ENSGALP00000007068	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.929
CYP3A4	CYP7A1	ENSGALP00000007048	ENSGALP00000054104	Uncharacterized protein; Belongs to the cytochrome P450 family.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.942
CYP3A4	NR1H4	ENSGALP00000007048	ENSGALP00000018906	Uncharacterized protein; Belongs to the cytochrome P450 family.	Farnesoid X receptor.	0.684
CYP3A5	CYP3A4	ENSGALP00000007068	ENSGALP00000007048	Uncharacterized protein.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.929
CYP3A5	CYP7A1	ENSGALP00000007068	ENSGALP00000054104	Uncharacterized protein.	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	0.929
CYP3A5	NR1H4	ENSGALP00000007068	ENSGALP00000018906	Uncharacterized protein.	Farnesoid X receptor.	0.550
CYP3A5	SLCO1B3	ENSGALP00000007068	ENSGALP00000065533	Uncharacterized protein.	Solute carrier organic anion transporter family member.	0.468
CYP7A1	CYP3A4	ENSGALP00000054104	ENSGALP00000007048	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.942
CYP7A1	CYP3A5	ENSGALP00000054104	ENSGALP00000007068	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.929
CYP7A1	INS	ENSGALP00000054104	ENSGALP00000010567	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	Insulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.	0.416
CYP7A1	NR1H4	ENSGALP00000054104	ENSGALP00000018906	Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family.	Farnesoid X receptor.	0.930
GAPDH	COL3A1	ENSGALP00000063325	ENSGALP00000051057	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...]	Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen.	0.888
GAPDH	IFNG	ENSGALP00000063325	ENSGALP00000016086	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...]	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	0.761
GAPDH	IL1B	ENSGALP00000063325	ENSGALP00000050171	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...]	Interleukin-1; Belongs to the IL-1 family.	0.853