STRINGSTRING
PI16 PI16 CD163 CD163 PECAM1 PECAM1 HIST1H2B5 HIST1H2B5 HIST1H2B5L HIST1H2B5L ACTA2 ACTA2 PDGFRA PDGFRA MKX MKX COL12A1 COL12A1 COL1A1 COL1A1 COL22A1 COL22A1 H2BE1 H2BE1 HIST1H2B8 HIST1H2B8 LOC107053803 LOC107053803 DPP4 DPP4 COL14A1 COL14A1 SCX SCX COL3A1 COL3A1 COL15A1 COL15A1 LY6E LY6E CXCL12 CXCL12 ALB ALB GAS6 GAS6 CDH5 CDH5 FMOD FMOD HIST1H2BO HIST1H2BO SOX9 SOX9 MARCO MARCO LAMA4 LAMA4 THBS4 THBS4 CXCR4 CXCR4 EGR1 EGR1 TNMD TNMD ACAN ACAN PROCR PROCR SPARC SPARC NUBP2 NUBP2 TPPP3 TPPP3 CD34 CD34 HSPA5 HSPA5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PI16SCP domain-containing protein; Belongs to the CRISP family. (784 aa)
CD163Uncharacterized protein. (661 aa)
PECAM1Platelet and endothelial cell adhesion molecule 1. (712 aa)
HIST1H2B5Histone H2B 5; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
HIST1H2B5LHistone H2B; Belongs to the histone H2B family. (126 aa)
ACTA2Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. (377 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. Required for normal development of the gastrointestinal tract. Plays a role in cell migration and chemotaxis in wound he [...] (1106 aa)
MKXMohawk homeobox. (350 aa)
COL12A1Collagen alpha-1(XII) chain; Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix. (3122 aa)
COL1A1Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1453 aa)
COL22A1VWFA domain-containing protein. (1599 aa)
H2BE1Histone H2B; Belongs to the histone H2B family. (118 aa)
HIST1H2B8Histone H2B 8; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
LOC107053803Histone H2B 7; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
DPP4Uncharacterized protein; Belongs to the peptidase S9B family. (760 aa)
COL14A1Collagen alpha-1(XIV) chain; An adhesive role by integrating collagen bundles. It is probably associated with the surface of interstitial collagen fibrils via COL1. The COL2 domain may then serve as a rigid arm which sticks out from the fibril and protrudes the large N-terminal globular domain into the extracellular space, where it might interact with other matrix molecules or cell surface receptors. (1888 aa)
SCXBasic helix-loop-helix transcription factor scleraxis; Plays an early essential role in mesoderm formation, as well as a later role in formation of somite-derived chondrogenic lineages. (187 aa)
COL3A1Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. (1460 aa)
COL15A1LAM_G_DOMAIN domain-containing protein. (1134 aa)
LY6ELymphocyte antigen 6E. (126 aa)
CXCL12SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (167 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. (565 aa)
GAS6Growth arrest specific 6. (667 aa)
CDH5Cadherin-5; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. (773 aa)
FMODFibromodulin; Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis (By similarity); Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (380 aa)
HIST1H2BOHistone H2B 1/2/3/4/6; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (126 aa)
SOX9Transcription factor SOX-9; Transcription factor that selectively activates enhancer through its interaction with a DNA-binding partner factor. Activates enhancer of COL2A1 through its binding with DNA sequence 5'-ATTCAT-3'. In response to bone morphogenetic protein stimulus, phosphorylation is induced and then sumoylation, allowing cooperation with SNAI2 to trigger neural crest delamination. Functions at the level of mesenchymal cell condensation by inducing cartilage development in limbs and by changing the aggregation properties of limb mesenchymal cells. Regulates the cell fate dec [...] (494 aa)
MARCOSRCR domain-containing protein. (476 aa)
LAMA4Laminin subunit alpha 4. (1827 aa)
THBS4Uncharacterized protein. (953 aa)
CXCR4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (362 aa)
EGR1Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...] (510 aa)
TNMDBRICHOS domain-containing protein. (319 aa)
ACANAggrecan core protein; This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. May play a regulatory role in the matrix assembly of the cartilage. (2089 aa)
PROCREndothelial protein C receptor. (223 aa)
SPARCSPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity). (298 aa)
NUBP2Cytosolic Fe-S cluster assembly factor NUBP2; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (272 aa)
TPPP3Tubulin polymerization promoting protein family member 3. (176 aa)
CD34CD34 molecule. (385 aa)
HSPA5Endoplasmic reticulum chaperone BiP; Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (By similarity). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to dis [...] (652 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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