STRINGSTRING
SLC11A1 SLC11A1 RACK1 RACK1 CDH1 CDH1 IL10 IL10 CASP9 CASP9 MLKL MLKL STAT3 STAT3 MTOR MTOR MIF MIF ITGB2 ITGB2 IL18 IL18 CASP8 CASP8 TLR5 TLR5 TBK1 TBK1 CLDN8 CLDN8 RHOA RHOA DNASE1L3 DNASE1L3 RIPK1 RIPK1 TLR2B TLR2B IRF7 IRF7 NFKBIA NFKBIA CCL19-2 CCL19-2 STAT1 STAT1 RELA RELA SPI1 SPI1 CCR7 CCR7 ILK ILK IL1B IL1B ATG5 ATG5 TLR2A TLR2A TRIM25 TRIM25 NOD1 NOD1 CX3CR1 CX3CR1 NOS1 NOS1 CLDN17 CLDN17 CD8A-2 CD8A-2 ACTB ACTB DNASE1L2 DNASE1L2 CASP18 CASP18 CDC42 CDC42 S1PR1 S1PR1 CCL19 CCL19 CASP3 CASP3 CASP1 CASP1 RIPK3 RIPK3 CD8A-3 CD8A-3 NOS3 NOS3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC11A1Natural resistance-associated macrophage protein 1; Divalent transition metal (iron and manganese) transporter involved in iron metabolism and host resistance to certain pathogens. Macrophage-specific membrane transport function. Controls natural resistance to infection with intracellular parasites. Pathogen resistance involves sequestration of Fe(2+) and Mn(2+), cofactors of both prokaryotic and eukaryotic catalases and superoxide dismutases, not only to protect the macrophage against its own generation of reactive oxygen species, but to deny the cations to the pathogen for synthesis [...] (555 aa)
RACK1Receptor of activated protein C kinase 1; Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes (By similarity). Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. (317 aa)
CDH1Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. E-cadherin is a ligand for integrin alpha- E/beta-7. (887 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (418 aa)
MLKLMixed lineage kinase domain like pseudokinase. (486 aa)
STAT3Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes. (771 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
MIFMacrophage migration inhibitory factor; Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity (By simi [...] (115 aa)
ITGB2Integrin beta. (773 aa)
IL18Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. (198 aa)
CASP8Uncharacterized protein; Belongs to the peptidase C14A family. (482 aa)
TLR5TLR5; Belongs to the Toll-like receptor family. (861 aa)
TBK1Protein kinase domain-containing protein. (729 aa)
CLDN8Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (224 aa)
RHOAGTP-binding protein. (193 aa)
DNASE1L3Deoxyribonuclease; Belongs to the DNase I family. (307 aa)
RIPK1Uncharacterized protein. (682 aa)
TLR2BToll-like receptor 2 type-2; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Mediates the response to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (781 aa)
IRF7Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the [...] (491 aa)
NFKBIANF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity). (318 aa)
CCL19-2SCY domain-containing protein. (99 aa)
STAT1Signal transducer and activator of transcription. (755 aa)
RELATranscription factor p65; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites tha [...] (559 aa)
SPI1ETS domain-containing protein. (266 aa)
CCR7C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (374 aa)
ILKIntegrin-linked kinase. (452 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (267 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (288 aa)
TLR2AToll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (955 aa)
TRIM25Tripartite motif containing 25. (633 aa)
NOD1Uncharacterized protein. (951 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1435 aa)
CLDN17Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (222 aa)
CD8A-2Ig-like domain-containing protein. (235 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
DNASE1L2Deoxyribonuclease; Belongs to the DNase I family. (278 aa)
CASP18Initiator caspase; Belongs to the peptidase C14A family. (464 aa)
CDC42Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. Plays a role in the extension and maintenance of the formation of thin, actin- rich surface projections called filopodia. Also plays a role in phagocytos [...] (194 aa)
S1PR1Sphingosine-1-phosphate receptor 1; Belongs to the G-protein coupled receptor 1 family. (379 aa)
CCL19C-C motif chemokine. (108 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (283 aa)
CASP1Uncharacterized protein; Belongs to the peptidase C14A family. (540 aa)
RIPK3Uncharacterized protein. (424 aa)
CD8A-3Ig-like domain-containing protein. (318 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1402 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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