STRINGSTRING
ADGRD1 ADGRD1 FRZB FRZB ACSBG1 ACSBG1 DMGDH DMGDH ALDH3A2 ALDH3A2 CHDH CHDH MORN4 MORN4 CRYAB CRYAB ACSL4 ACSL4 AXL AXL HACD1 HACD1 COL1A2 COL1A2 COL28A1 COL28A1 SERPINH1 SERPINH1 HACD2 HACD2 TOM1 TOM1 MYLIP MYLIP CYTL1 CYTL1 PXDN PXDN TYR TYR AGXT AGXT HBE1 HBE1 PRKAG3 PRKAG3 TYRP1 TYRP1 MYOD1 MYOD1 CHCHD10 CHCHD10 BORCS6 BORCS6 OGN OGN CAV1 CAV1 ACACA ACACA MYH10 MYH10 ECI1 ECI1 FASN FASN IGF2 IGF2 HBA1 HBA1 HBAD HBAD ACAA2 ACAA2 RET RET SMYD1 SMYD1 ACTB ACTB ACSL1 ACSL1 ACADL ACADL TSC22D4 TSC22D4 SELENOW SELENOW GCDH GCDH ATP8A1 ATP8A1 MGARP MGARP AGXT2 AGXT2 CBARP CBARP ASB16 ASB16
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADGRD1G protein-coupled receptor 133 variant X1; Belongs to the G-protein coupled receptor 2 family. (926 aa)
FRZBSecreted frizzled-related protein 3; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. (315 aa)
ACSBG1Acyl-CoA synthetase bubblegum family member 1. (688 aa)
DMGDHDimethylglycine dehydrogenase. (868 aa)
ALDH3A2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (490 aa)
CHDHCholine dehydrogenase. (716 aa)
MORN4Uncharacterized protein. (146 aa)
CRYABAlpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. (174 aa)
ACSL4Acyl-CoA synthetase long chain family member 4. (670 aa)
AXLTyrosine-protein kinase receptor TYRO3; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, enhances PI3- kinase activity and activates the AKT survival pathway, including nuclear translocation of NF-kappa-B [...] (873 aa)
HACD1Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (245 aa)
COL1A2Collagen alpha-2(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1363 aa)
COL28A1Collagen type XXVIII alpha 1 chain. (1140 aa)
SERPINH1Serpin H1; Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. (405 aa)
HACD2Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors [...] (246 aa)
TOM1Target of Myb protein 1; May be involved in intracellular trafficking. Probable association with membranes; Belongs to the TOM1 family. (515 aa)
MYLIPUncharacterized protein. (445 aa)
CYTL1Cytokine like 1. (132 aa)
PXDNPeroxidasin. (1611 aa)
TYRTyrosinase; This is a copper-containing oxidase that functions in the formation of pigments such as melanins and other polyphenolic compounds. Catalyzes the initial and rate limiting step in the cascade of reactions leading to melanin production from tyrosine. In addition to hydroxylating tyrosine to DOPA (3,4-dihydroxyphenylalanine), also catalyzes the oxidation of DOPA to DOPA-quinone, and possibly the oxidation of DHI (5,6-dihydroxyindole) to indole-5,6 quinone. (537 aa)
AGXTAlanine--glyoxylate and serine--pyruvate aminotransferase. (473 aa)
HBE1Beta-H globin; Belongs to the globin family. (147 aa)
PRKAG3Uncharacterized protein. (382 aa)
TYRP15,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. (536 aa)
MYOD1Myoblast determination protein 1 homolog; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). (299 aa)
CHCHD10Coiled-coil-helix-coiled-coil-helix domain containing 10. (90 aa)
BORCS6BLOC-1 related complex subunit 6. (374 aa)
OGNMimecan; Induces bone formation in conjunction with TGF-beta-1 or TGF- beta-2; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily. (294 aa)
CAV1Caveolin-1; May act as a positive regulator of T-cell coactivation. May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). (178 aa)
ACACAAcetyl-CoA carboxylase; Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. (2355 aa)
MYH10Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2016 aa)
ECI1Uncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (366 aa)
FASN3-hydroxyacyl-[acyl-carrier-protein] dehydratase; Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (2512 aa)
IGF2Insulin-like growth factor II; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling. (187 aa)
HBA1Hemoglobin subunit alpha-A; Involved in oxygen transport from the lung to the various peripheral tissues; Belongs to the globin family. (142 aa)
HBADHemoglobin subunit alpha-D; Involved in oxygen transport from the lung to the various peripheral tissues. (141 aa)
ACAA2Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (423 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1105 aa)
SMYD1Uncharacterized protein. (491 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
ACSL1AMP-binding domain-containing protein. (699 aa)
ACADLUncharacterized protein. (437 aa)
TSC22D4Uncharacterized protein. (243 aa)
SELENOWSelenoprotein W; Plays a role as a glutathione (GSH)-dependent antioxidant. May be involved in a redox-related process. May play a role in the myopathies of selenium deficiency (By similarity); Belongs to the SelWTH family. Selenoprotein W subfamily. (73 aa)
GCDHGlutaryl-CoA dehydrogenase. (476 aa)
ATP8A1Phospholipid-transporting ATPase; Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. (1164 aa)
MGARPMitochondria localized glutamic acid rich protein. (244 aa)
AGXT2Alanine--glyoxylate aminotransferase 2; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (471 aa)
CBARPCACN subunit beta associated regulatory protein. (852 aa)
ASB16Ankyrin repeat and SOCS box containing 16. (504 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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