(30 nodes) (2022) Single cell RNA sequencing analysis of mouse cochlear supporting cell transcriptomes with activated ERBB2 receptor indicates a cell-specific response that promotes CD44 activation. network (Gallus gallus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Predicted Interactions

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Your Input:
	EMID1	EMI domain containing 1. (698 aa)
	MMP9	Uncharacterized protein. (713 aa)
	CASP3	Caspase-3; Belongs to the peptidase C14A family. (283 aa)
	CD63	Tetraspanin. (227 aa)
	CD44	Link domain-containing protein. (696 aa)
	BGLAP	Osteocalcin; Constitutes 1-2% of the total bone protein. It binds strongly to apatite and calcium. (97 aa)
	ITGB1	Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-1 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (822 aa)
	CDH1	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. E-cadherin is a ligand for integrin alpha- E/beta-7. (887 aa)
	FGFR3	Fibroblast growth factor receptor 3; Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Phosphorylates PLCG1, CBL and FRS2. Ligand binding l [...] (806 aa)
	CRYAB	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens. (174 aa)
	PDZK1IP1	Uncharacterized protein. (115 aa)
	NPY	C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (97 aa)
	WNT10A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (388 aa)
	EGFR	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF and TGFA/TGF-alpha. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including [...] (1226 aa)
	ERBB3	Protein kinase domain-containing protein. (1319 aa)
	SMAGP	Small cell adhesion glycoprotein. (92 aa)
	KRT17	IF rod domain-containing protein; Belongs to the intermediate filament family. (559 aa)
	LFNG	Beta-1,3-N-acetylglucosaminyltransferase lunatic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Essential mediator of somite segmentation and patterning. (363 aa)
	PDIA6	Protein disulfide isomerase family A member 6; Belongs to the protein disulfide isomerase family. (447 aa)
	PRSS23	Serine protease 23. (372 aa)
	ACBD7	Acyl-CoA binding domain containing 7. (88 aa)
	S100B	EF-hand domain-containing protein; Belongs to the S-100 family. (92 aa)
	DDOST	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit; Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol- pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across t [...] (440 aa)
	ERBB4	Receptor protein-tyrosine kinase. (1276 aa)
	TMSB4X	Thymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
	LAMA3	Laminin subunit alpha 3. (3448 aa)
	ERBB2	Receptor protein-tyrosine kinase. (1200 aa)
	EGF	Uncharacterized protein. (1283 aa)
	EEF1A1	Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (473 aa)
	KY	TGc domain-containing protein. (684 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP3	CD44	ENSGALP00000068843	ENSGALP00000056897	Caspase-3; Belongs to the peptidase C14A family.	Link domain-containing protein.	0.638
CASP3	CDH1	ENSGALP00000068843	ENSGALP00000000855	Caspase-3; Belongs to the peptidase C14A family.	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. E-cadherin is a ligand for integrin alpha- E/beta-7.	0.940
CASP3	CRYAB	ENSGALP00000068843	ENSGALP00000012892	Caspase-3; Belongs to the peptidase C14A family.	Alpha-crystallin B chain; May contribute to the transparency and refractive index of the lens.	0.549
CASP3	EGF	ENSGALP00000068843	ENSGALP00000044972	Caspase-3; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.740
CASP3	EGFR	ENSGALP00000068843	ENSGALP00000053328	Caspase-3; Belongs to the peptidase C14A family.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF and TGFA/TGF-alpha. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including [...]	0.716
CASP3	MMP9	ENSGALP00000068843	ENSGALP00000068659	Caspase-3; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.766
CD44	CASP3	ENSGALP00000056897	ENSGALP00000068843	Link domain-containing protein.	Caspase-3; Belongs to the peptidase C14A family.	0.638
CD44	CD63	ENSGALP00000056897	ENSGALP00000074037	Link domain-containing protein.	Tetraspanin.	0.535
CD44	CDH1	ENSGALP00000056897	ENSGALP00000000855	Link domain-containing protein.	Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. E-cadherin is a ligand for integrin alpha- E/beta-7.	0.766
CD44	EGF	ENSGALP00000056897	ENSGALP00000044972	Link domain-containing protein.	Uncharacterized protein.	0.810
CD44	EGFR	ENSGALP00000056897	ENSGALP00000053328	Link domain-containing protein.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF and TGFA/TGF-alpha. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including [...]	0.784
CD44	ERBB2	ENSGALP00000056897	ENSGALP00000044764	Link domain-containing protein.	Receptor protein-tyrosine kinase.	0.497
CD44	ERBB3	ENSGALP00000056897	ENSGALP00000051173	Link domain-containing protein.	Protein kinase domain-containing protein.	0.423
CD44	ITGB1	ENSGALP00000056897	ENSGALP00000054354	Link domain-containing protein.	Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-1 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...]	0.516
CD44	LAMA3	ENSGALP00000056897	ENSGALP00000043775	Link domain-containing protein.	Laminin subunit alpha 3.	0.905
CD44	MMP9	ENSGALP00000056897	ENSGALP00000068659	Link domain-containing protein.	Uncharacterized protein.	0.960
CD63	CD44	ENSGALP00000074037	ENSGALP00000056897	Tetraspanin.	Link domain-containing protein.	0.535
CD63	EGFR	ENSGALP00000074037	ENSGALP00000053328	Tetraspanin.	Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF and TGFA/TGF-alpha. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including [...]	0.409
CD63	ITGB1	ENSGALP00000074037	ENSGALP00000054354	Tetraspanin.	Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-1 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...]	0.442
CD63	MMP9	ENSGALP00000074037	ENSGALP00000068659	Tetraspanin.	Uncharacterized protein.	0.479