(15 nodes) (2023) An exploration of alginate oligosaccharides modulating intestinal inflammatory networks via gut microbiota. network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	HYAL1	Hyaluronidase. (436 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
	HYAL3	Hyaluronidase. (584 aa)
	HYAL6	Hyaluronidase. (579 aa)
	SPAM1	Hyaluronidase. (502 aa)
	CD4	Uncharacterized protein. (487 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (267 aa)
	CLDN1	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (211 aa)
	IL4	Interleukin 4. (136 aa)
	IL17A	Uncharacterized protein. (169 aa)
	TLR3	Toll-like receptor 3; Belongs to the Toll-like receptor family. (896 aa)
	TLR4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
	STAT5A	Signal transducer and activator of transcription. (764 aa)
	HYAL2	Hyaluronidase. (478 aa)
	IL10	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	HYAL1	ENSGALP00000065611	ENSGALP00000001136	Uncharacterized protein.	Hyaluronidase.	0.551
CD4	HYAL2	ENSGALP00000065611	ENSGALP00000003336	Uncharacterized protein.	Hyaluronidase.	0.509
CD4	HYAL3	ENSGALP00000065611	ENSGALP00000067808	Uncharacterized protein.	Hyaluronidase.	0.554
CD4	HYAL6	ENSGALP00000065611	ENSGALP00000067729	Uncharacterized protein.	Hyaluronidase.	0.550
CD4	IL10	ENSGALP00000065611	ENSGALP00000001310	Uncharacterized protein.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.982
CD4	IL17A	ENSGALP00000065611	ENSGALP00000026862	Uncharacterized protein.	Uncharacterized protein.	0.981
CD4	IL1B	ENSGALP00000065611	ENSGALP00000050171	Uncharacterized protein.	Interleukin-1; Belongs to the IL-1 family.	0.957
CD4	IL4	ENSGALP00000065611	ENSGALP00000039130	Uncharacterized protein.	Interleukin 4.	0.979
CD4	IL6	ENSGALP00000065611	ENSGALP00000068117	Uncharacterized protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.982
CD4	SPAM1	ENSGALP00000065611	ENSGALP00000067298	Uncharacterized protein.	Hyaluronidase.	0.500
CD4	STAT5A	ENSGALP00000065611	ENSGALP00000005182	Uncharacterized protein.	Signal transducer and activator of transcription.	0.753
CD4	TLR3	ENSGALP00000065611	ENSGALP00000021914	Uncharacterized protein.	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.869
CD4	TLR4	ENSGALP00000065611	ENSGALP00000011319	Uncharacterized protein.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.888
CLDN1	IL10	ENSGALP00000043047	ENSGALP00000001310	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.760
CLDN1	IL17A	ENSGALP00000043047	ENSGALP00000026862	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Uncharacterized protein.	0.444
CLDN1	IL1B	ENSGALP00000043047	ENSGALP00000050171	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Interleukin-1; Belongs to the IL-1 family.	0.770
CLDN1	IL4	ENSGALP00000043047	ENSGALP00000039130	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Interleukin 4.	0.501
CLDN1	IL6	ENSGALP00000043047	ENSGALP00000068117	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.752
CLDN1	TLR4	ENSGALP00000043047	ENSGALP00000011319	Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.711
HYAL1	CD4	ENSGALP00000001136	ENSGALP00000065611	Hyaluronidase.	Uncharacterized protein.	0.551