STRINGSTRING
SPARC SPARC LGALS2 LGALS2 PODXL PODXL PRG4 PRG4 SLIT3 SLIT3 IL15 IL15 IL6 IL6 TFPI2 TFPI2 POSTN POSTN COL11A1 COL11A1 UPK3B UPK3B COL1A1 COL1A1 PLA2G2A PLA2G2A WNT3A WNT3A COL9A3 COL9A3 RARRES2 RARRES2 TNFRSF11B TNFRSF11B ROBO4 ROBO4 EGFR EGFR COL3A1 COL3A1 BMP3 BMP3 SBSPON SBSPON TBX18 TBX18 CXCL12 CXCL12 ALAS1 ALAS1 TNNT1 TNNT1 SLIT2 SLIT2 TWIST1 TWIST1 WNT2B WNT2B SMPD3 SMPD3 GPC3 GPC3 CCBE1 CCBE1 TCF21 TCF21 CALB2 CALB2 FGF9 FGF9 TMSB4X TMSB4X THY1 THY1 TGFB3 TGFB3 HBBA HBBA CA9 CA9 FGF2 FGF2 FZD4 FZD4 EGFL6 EGFL6 BMP4 BMP4 CXCR4 CXCR4 CFI CFI WT1 WT1 MGP MGP CENPF CENPF SFRP2 SFRP2 SFRP5 SFRP5 SEMA3D SEMA3D CXCL14 CXCL14 SBSPONL SBSPONL MSLN MSLN RSPO1 RSPO1 RAMP1 RAMP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SPARCSPARC; Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity (By similarity). (298 aa)
LGALS2Galectin. (131 aa)
PODXLPodocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro- adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubul [...] (589 aa)
PRG4Uncharacterized protein. (370 aa)
SLIT3Uncharacterized protein. (1641 aa)
IL15Interleukin; Belongs to the IL-15/IL-21 family. (187 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
TFPI2Tissue factor pathway inhibitor. (239 aa)
POSTNUncharacterized protein. (857 aa)
COL11A1Fibrillar collagen NC1 domain-containing protein. (888 aa)
UPK3BUroplakin 3B. (194 aa)
COL1A1Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1453 aa)
PLA2G2APhospholipase A(2). (144 aa)
WNT3AProtein Wnt-3a; [Isoform 1]: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Regulates chick apical ectodermal ridge formation. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). ECO:0000250|UniProtKB:P56704. (376 aa)
COL9A3Collagen alpha-3(IX) chain; Collagen type IX is a minor cartilage non-fibrillar collagen. It is associated with type II collagen fibrils; Belongs to the fibril-associated collagens with interrupted helices (FACIT) family. (675 aa)
RARRES2Chemerin. (162 aa)
TNFRSF11BTumor necrosis factor receptor superfamily member 11B; Acts as decoy receptor for TNFSF11/RANKL and thereby neutralizes its function in osteoclastogenesis. (402 aa)
ROBO4Uncharacterized protein. (1063 aa)
EGFREpidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF and TGFA/TGF-alpha. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including [...] (1226 aa)
COL3A1Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. (1460 aa)
BMP3Bone morphogenetic protein 3; Belongs to the TGF-beta family. (462 aa)
SBSPONSomatomedin B and thrombospondin type 1 domain containing. (360 aa)
TBX18Uncharacterized protein. (589 aa)
CXCL12SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (167 aa)
ALAS15-aminolevulinate synthase, nonspecific, mitochondrial; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. (635 aa)
TNNT1Uncharacterized protein. (272 aa)
SLIT2Uncharacterized protein. (1533 aa)
TWIST1CTwist. (190 aa)
WNT2BProtein Wnt-2b; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Acts as an upstream regulator of FGF10 in the lateral plate mesoderm during limb initiation in the embryo. (385 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (662 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (711 aa)
CCBE1Collagen and calcium binding EGF domains 1. (329 aa)
TCF21BHLH domain-containing protein. (179 aa)
CALB2Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons. (311 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa)
TMSB4XThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (44 aa)
THY1Thy-1 membrane glycoprotein; May play a role in cell-cell or cell-ligand interactions during synaptogenesis and other events in the brain. (161 aa)
TGFB3Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] (535 aa)
HBBAHemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. The beta chain is a component of adult hemoglobin A and D. (147 aa)
CA9Carbonic anhydrase 9; Belongs to the alpha-carbonic anhydrase family. (397 aa)
FGF2Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family. (158 aa)
FZD4Frizzled-4; Receptor for Wnt proteins (By similarity). Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 ki [...] (525 aa)
EGFL6EGF like domain multiple 6. (370 aa)
BMP4Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. (404 aa)
CXCR4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (362 aa)
CFIUncharacterized protein; Belongs to the peptidase S1 family. (596 aa)
WT1Uncharacterized protein. (417 aa)
MGPMatrix Gla protein; Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation; Belongs to the osteocalcin/matrix Gla protein family. (103 aa)
CENPFUncharacterized protein. (2935 aa)
SFRP2Secreted frizzled-related protein 2; Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP2 appears to be associated with myogenesis. (292 aa)
SFRP5Uncharacterized protein. (312 aa)
SEMA3DSemaphorin-3D; Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin; Belongs to the semaphorin family. (761 aa)
CXCL14Jun-suppressed chemokine. (98 aa)
SBSPONLSMB domain-containing protein. (250 aa)
MSLNMesothelin. (655 aa)
RSPO1R-spondin 1. (260 aa)
RAMP1Receptor activity modifying protein 1. (125 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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