STRINGSTRING
CD34 CD34 TAL1 TAL1 ANK1 ANK1 ZNF410 ZNF410 CTCF CTCF DNMT1 DNMT1 LOC101747588 LOC101747588 BCL11A BCL11A LDB1 LDB1 MYB MYB LMO2 LMO2 HBBA HBBA HBE1 HBE1 CHD4 CHD4 BCL2 BCL2 CXCR4 CXCR4 HMGB3 HMGB3 PGK2 PGK2 HBZ HBZ SOX6 SOX6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD34CD34 molecule. (385 aa)
TAL1T-cell acute lymphocytic leukemia protein 1 homolog; Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. (396 aa)
ANK1Ankyrin 1. (1984 aa)
ZNF410Uncharacterized protein. (445 aa)
CTCFTranscriptional repressor CTCF; Acts as both a transcriptional activator and repressor of the MYC gene. (739 aa)
DNMT1DNA (cytosine-5)-methyltransferase 1; Methylates CpG residues. Preferentially methylates hemimethylated DNA. It is responsible for maintaining methylation patterns established in development. Mediates transcriptional repression by direct binding to HDAC2. Plays a role in promoter hypermethylation and transcriptional silencing of tumor suppressor genes (TSGs) or other tumor-related genes. Also required to maintain a transcriptionally repressive state of genes in undifferentiated embryonic stem cells (ESCs). Associates at promoter regions of tumor suppressor genes (TSGs) leading to their [...] (1417 aa)
LOC101747588Uncharacterized protein. (753 aa)
BCL11AUncharacterized protein. (796 aa)
LDB1LIM domain-binding protein 1; Binds to the LIM domain of a wide variety of LIM domain- containing transcription factors. (416 aa)
MYBTranscriptional activator Myb; Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. (785 aa)
LMO2LIM domain only 2. (216 aa)
HBBAHemoglobin subunit beta; Involved in oxygen transport from the lung to the various peripheral tissues. The beta chain is a component of adult hemoglobin A and D. (147 aa)
HBE1Beta-H globin; Belongs to the globin family. (147 aa)
CHD4Uncharacterized protein. (1145 aa)
BCL2Apoptosis regulator Bcl-2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). (233 aa)
CXCR4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (362 aa)
HMGB3High mobility group protein B3; Multifunctional protein with various roles in different cellular compartments. May act in a redox sensitive manner. Associates with chromatin and binds DNA with a preference to non-canonical DNA structures such as single-stranded DNA. Can bent DNA and enhance DNA flexibility by looping thus providing a mechanism to promote activities on various gene promoters (By similarity). Binds to the delta-1 crystallin/ASL1 enhancer. Proposed to be involved in the innate immune response to nucleic acids by acting as a cytoplasmic promiscuous immunogenic DNA/RNA sens [...] (202 aa)
PGK2Phosphoglycerate kinase; Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility. (417 aa)
HBZHemoglobin subunit pi; The pi' chain is the counterpart of the alpha chain in the major early embryonic hemoglobin P; Belongs to the globin family. (142 aa)
SOX6HMG box domain-containing protein. (817 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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