26 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	SPR	Sepiapterin reductase. (268 aa)
	CREB3	cAMP responsive element binding protein 3. (390 aa)
	TTC39B	Tetratricopeptide repeat domain 39B. (554 aa)
	APOD	Apolipoprotein D; Belongs to the calycin superfamily. Lipocalin family. (189 aa)
	NDUFB3	Uncharacterized protein. (98 aa)
	CREB3L1	cAMP responsive element binding protein 3 like 1. (506 aa)
	ME1	Malic enzyme. (655 aa)
	MC1R	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family. (314 aa)
	MITF	BHLH domain-containing protein. (519 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (503 aa)
	CSF1	Uncharacterized protein. (493 aa)
	SELENBP1	Uncharacterized protein. (471 aa)
	QDPR	Uncharacterized protein. (238 aa)
	EEF2	Elongation factor 2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. (858 aa)
	ASIP	Agouti signaling protein. (139 aa)
	PMEL	Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family. (740 aa)
	LOC107056277	Uncharacterized protein. (491 aa)
	GGH	Folate gamma-glutamyl hydrolase. (439 aa)
	TYRP1	5,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin. (536 aa)
	DCT	L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels. (521 aa)
	PLA2G10	Phospholipase A(2). (155 aa)
	COX7A2	Uncharacterized protein. (83 aa)
	PNPLA2	PNPLA2/ATGL. (483 aa)
	FABP2	Intestinal fatty acid-binding protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
	CYP2J19	Uncharacterized protein; Belongs to the cytochrome P450 family. (490 aa)
	RDH11	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (326 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APOD	SCARB1	ENSGALP00000011312	ENSGALP00000065433	Apolipoprotein D; Belongs to the calycin superfamily. Lipocalin family.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.609
ASIP	DCT	ENSGALP00000054181	ENSGALP00000035733	Agouti signaling protein.	L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels.	0.584
ASIP	MC1R	ENSGALP00000054181	ENSGALP00000071620	Agouti signaling protein.	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family.	0.999
ASIP	MITF	ENSGALP00000054181	ENSGALP00000070157	Agouti signaling protein.	BHLH domain-containing protein.	0.744
ASIP	TYRP1	ENSGALP00000054181	ENSGALP00000037537	Agouti signaling protein.	5,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.	0.860
COX7A2	NDUFB3	ENSGALP00000031018	ENSGALP00000013392	Uncharacterized protein.	Uncharacterized protein.	0.581
CREB3	CREB3L1	ENSGALP00000003967	ENSGALP00000013658	cAMP responsive element binding protein 3.	cAMP responsive element binding protein 3 like 1.	0.937
CREB3L1	CREB3	ENSGALP00000013658	ENSGALP00000003967	cAMP responsive element binding protein 3 like 1.	cAMP responsive element binding protein 3.	0.937
CYP2J19	LOC107056277	ENSGALP00000018598	ENSGALP00000048240	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein.	0.805
CYP2J19	RDH11	ENSGALP00000018598	ENSGALP00000015508	Uncharacterized protein; Belongs to the cytochrome P450 family.	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.574
CYP2J19	SCARB1	ENSGALP00000018598	ENSGALP00000065433	Uncharacterized protein; Belongs to the cytochrome P450 family.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.443
CYP2J19	TTC39B	ENSGALP00000018598	ENSGALP00000008685	Uncharacterized protein; Belongs to the cytochrome P450 family.	Tetratricopeptide repeat domain 39B.	0.487
DCT	ASIP	ENSGALP00000035733	ENSGALP00000054181	L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels.	Agouti signaling protein.	0.584
DCT	MC1R	ENSGALP00000035733	ENSGALP00000071620	L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels.	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family.	0.768
DCT	MITF	ENSGALP00000035733	ENSGALP00000070157	L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels.	BHLH domain-containing protein.	0.861
DCT	PMEL	ENSGALP00000035733	ENSGALP00000051268	L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels.	Melanocyte protein PMEL; Might be required for polymerization of melanin onto the core structure of melanosomes with enzymic function of tyrosinase; Belongs to the PMEL/NMB family.	0.844
DCT	TYRP1	ENSGALP00000035733	ENSGALP00000037537	L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels.	5,6-dihydroxyindole-2-carboxylic acid oxidase; Plays a role in melanin biosynthesis. Catalyzes the oxidation of 5,6-dihydroxyindole-2-carboxylic acid (DHICA) into indole-5,6- quinone-2-carboxylic acid. May regulate or influence the type of melanin synthesized. Also to a lower extent, capable of hydroxylating tyrosine and producing melanin.	0.941
LOC107056277	CYP2J19	ENSGALP00000048240	ENSGALP00000018598	Uncharacterized protein.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.805
MC1R	ASIP	ENSGALP00000071620	ENSGALP00000054181	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family.	Agouti signaling protein.	0.999
MC1R	DCT	ENSGALP00000071620	ENSGALP00000035733	Melanocyte-stimulating hormone receptor; Receptor for MSH (alpha, beta) and ACTH. Does not seem to be active with gamma-MSH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase (By similarity). Belongs to the G-protein coupled receptor 1 family.	L-dopachrome tautomerase; Catalyzes the conversion of L-dopachrome into 5,6- dihydroxyindole-2-carboxylic acid (DHICA). Involved in regulating eumelanin and phaeomelanin levels.	0.768