(29 nodes) (2023) Reprogramming viral immune evasion for a rational design of next-generation vaccines for RNA viruses. network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC101748744	Serine protease; Belongs to the peptidase S1B family. (363 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
	CD4	Uncharacterized protein. (487 aa)
	CD8A-2	Ig-like domain-containing protein. (235 aa)
	IFNAR1	Uncharacterized protein. (569 aa)
	LGALS3	Galectin. (258 aa)
	CACUL1	Cullin domain-containing protein; Belongs to the cullin family. (377 aa)
	CREBBP	CREB binding protein. (2522 aa)
	TRIM25	Tripartite motif containing 25. (633 aa)
	TYK2	Tyrosine-protein kinase. (1212 aa)
	STAT2	Signal transducer and activator of transcription. (961 aa)
	CHUK	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (724 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (267 aa)
	RELA	Transcription factor p65; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites tha [...] (559 aa)
	STAT1	Signal transducer and activator of transcription. (755 aa)
	IRF7	Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the [...] (491 aa)
	MX1	Interferon-induced GTP-binding protein Mx; Does not show activity against influenza virus, VSV, Thogoto virus or Sendai virus. (705 aa)
	TLR3	Toll-like receptor 3; Belongs to the Toll-like receptor family. (896 aa)
	JAK1	Tyrosine-protein kinase. (1150 aa)
	EIF2AK2	Uncharacterized protein. (550 aa)
	TBK1	Protein kinase domain-containing protein. (729 aa)
	PIAS1	Uncharacterized protein. (727 aa)
	NUP62	Nucleoporin 62. (574 aa)
	CD8A-3	Ig-like domain-containing protein. (318 aa)
	TLR7	Toll-like receptor 7; Belongs to the Toll-like receptor family. (1059 aa)
	IFNA3	Interferon. (193 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (187 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
	ENDOU	Endonuclease, poly(U) specific. (356 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	CD8A-2	ENSGALP00000065611	ENSGALP00000059832	Uncharacterized protein.	Ig-like domain-containing protein.	0.984
CD4	CD8A-3	ENSGALP00000065611	ENSGALP00000071819	Uncharacterized protein.	Ig-like domain-containing protein.	0.982
CD4	CHUK	ENSGALP00000065611	ENSGALP00000051589	Uncharacterized protein.	Inhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.	0.403
CD4	EIF2AK2	ENSGALP00000065611	ENSGALP00000017163	Uncharacterized protein.	Uncharacterized protein.	0.438
CD4	IFNA3	ENSGALP00000065611	ENSGALP00000070204	Uncharacterized protein.	Interferon.	0.955
CD4	IFNAR1	ENSGALP00000065611	ENSGALP00000055436	Uncharacterized protein.	Uncharacterized protein.	0.579
CD4	IL15	ENSGALP00000065611	ENSGALP00000069101	Uncharacterized protein.	Interleukin; Belongs to the IL-15/IL-21 family.	0.908
CD4	IL1B	ENSGALP00000065611	ENSGALP00000050171	Uncharacterized protein.	Interleukin-1; Belongs to the IL-1 family.	0.957
CD4	IL6	ENSGALP00000065611	ENSGALP00000068117	Uncharacterized protein.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.982
CD4	IRF7	ENSGALP00000065611	ENSGALP00000038233	Uncharacterized protein.	Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the [...]	0.724
CD4	JAK1	ENSGALP00000065611	ENSGALP00000017948	Uncharacterized protein.	Tyrosine-protein kinase.	0.581
CD4	LGALS3	ENSGALP00000065611	ENSGALP00000055146	Uncharacterized protein.	Galectin.	0.847
CD4	LOC101748744	ENSGALP00000065611	ENSGALP00000009215	Uncharacterized protein.	Serine protease; Belongs to the peptidase S1B family.	0.429
CD4	MX1	ENSGALP00000065611	ENSGALP00000025952	Uncharacterized protein.	Interferon-induced GTP-binding protein Mx; Does not show activity against influenza virus, VSV, Thogoto virus or Sendai virus.	0.574
CD4	STAT1	ENSGALP00000065611	ENSGALP00000046362	Uncharacterized protein.	Signal transducer and activator of transcription.	0.855
CD4	STAT2	ENSGALP00000065611	ENSGALP00000052740	Uncharacterized protein.	Signal transducer and activator of transcription.	0.686
CD4	TBK1	ENSGALP00000065611	ENSGALP00000015982	Uncharacterized protein.	Protein kinase domain-containing protein.	0.496
CD4	TLR3	ENSGALP00000065611	ENSGALP00000021914	Uncharacterized protein.	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.869
CD4	TLR7	ENSGALP00000065611	ENSGALP00000070844	Uncharacterized protein.	Toll-like receptor 7; Belongs to the Toll-like receptor family.	0.897
CD4	TYK2	ENSGALP00000065611	ENSGALP00000053236	Uncharacterized protein.	Tyrosine-protein kinase.	0.504