STRINGSTRING
RAD23B RAD23B NEIL1 NEIL1 BRCA1 BRCA1 ERCC4 ERCC4 PMS2 PMS2 TOP3A TOP3A ANXA7 ANXA7 ANXA8L1 ANXA8L1 ATP23 ATP23 ALDH1A1 ALDH1A1 MSH3 MSH3 NEIL2 NEIL2 LIG4 LIG4 BRCA2 BRCA2 ATM ATM YY2 YY2 C10orf2 C10orf2 RAD50 RAD50 XPA XPA TOP1 TOP1 ANXA13 ANXA13 TDG TDG SOX2 SOX2 RAD51C RAD51C RAD51D RAD51D DDB1 DDB1 ANXA5 ANXA5 CD44 CD44 MGMT MGMT MUTYH MUTYH ACTB ACTB ANXA4 ANXA4 TOP3B TOP3B ANXA11 ANXA11 XRCC5 XRCC5 RAD51B RAD51B MYC MYC ERCC8 ERCC8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RAD23BRAD23 homolog B, nucleotide excision repair protein. (504 aa)
NEIL1FPG_CAT domain-containing protein. (382 aa)
BRCA1Uncharacterized protein. (1749 aa)
ERCC4ERCC4 domain-containing protein. (903 aa)
PMS2Mismatch repair endonuclease PMS2; Component of the post-replicative DNA mismatch repair system (MMR). Involved in B cell growth by positively regulating B cell proliferation and controlling replication efficiency. Controls cell cycle to prevent re-replication and defects in DNA damage-induced G2 checkpoint. Doesn't seem to counteract or control the immunoglobulin gene conversion (Ig GC) and to contribute to guanine/uracil mismatch repair. (869 aa)
TOP3ADNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1020 aa)
ANXA7Annexin. (459 aa)
ANXA8L1Annexin. (327 aa)
ATP23Mitochondrial inner membrane protease ATP23; Belongs to the peptidase M76 family. (242 aa)
ALDH1A1Retinal dehydrogenase 1; Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (By similarity). (509 aa)
MSH3DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1090 aa)
NEIL2FPG_CAT domain-containing protein. (328 aa)
LIG4DNA ligase 4; Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. (912 aa)
BRCA2Tower domain-containing protein. (3397 aa)
ATMNon-specific serine/threonine protein kinase. (3050 aa)
YY2Uncharacterized protein. (420 aa)
C10orf2Twinkle protein, mitochondrial; Involved in mitochondrial DNA (mtDNA) metabolism. Could function as an adenine nucleotide-dependent DNA helicase. Function inferred to be critical for lifetime maintenance of mtDNA integrity (By similarity). (669 aa)
RAD50Zinc-hook domain-containing protein. (1313 aa)
XPADNA repair protein complementing XP-A cells homolog; Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region (By similarity). Belongs to the XPA family. (270 aa)
TOP1DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...] (747 aa)
ANXA13Annexin. (317 aa)
TDGUDG domain-containing protein. (546 aa)
SOX2Transcription factor SOX-2; Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development. (312 aa)
RAD51CRAD51 paralog C. (360 aa)
RAD51DRECA_2 domain-containing protein. (327 aa)
DDB1DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (By similarity). Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein li [...] (1139 aa)
ANXA5Annexin A5; Collagen-binding protein. (321 aa)
CD44Link domain-containing protein. (696 aa)
MGMTO-6-methylguanine-DNA methyltransferase. (260 aa)
MUTYHAdenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (511 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
ANXA4Annexin. (350 aa)
TOP3BDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa)
ANXA11Annexin. (496 aa)
XRCC5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (711 aa)
RAD51BRAD51 paralog B. (415 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (429 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (399 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.