STRINGSTRING
VCL VCL ZNF511 ZNF511 MED27 MED27 KRT13 KRT13 SNF8 SNF8 KLHDC3 KLHDC3 KLHL9 KLHL9 NECAB1 NECAB1 EPB41L3 EPB41L3 MATN2 MATN2 GAPDH GAPDH CCDC89 CCDC89 ACTB ACTB FNIP1 FNIP1 CACUL1 CACUL1 GMCL1 GMCL1 KLHL15 KLHL15 CUL2 CUL2 TOR1AIP2 TOR1AIP2 CUL4B CUL4B CDK5R1 CDK5R1 CUL1 CUL1 FBXO38 FBXO38 CUL5 CUL5 FEM1B FEM1B KLHDC2 KLHDC2 CUL4A CUL4A BIN1 BIN1 KLHL8 KLHL8 KLHDC10 KLHDC10 PGK2 PGK2 DCAF12L2 DCAF12L2 APPBP2 APPBP2 CUL3 CUL3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
VCLVinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family. (1135 aa)
ZNF511Zinc finger protein 511. (264 aa)
MED27Uncharacterized protein. (344 aa)
KRT13IF rod domain-containing protein; Belongs to the intermediate filament family. (463 aa)
SNF8Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
KLHDC3Kelch domain containing 3. (382 aa)
KLHL9Kelch-like protein 13; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis (By similarity). (655 aa)
NECAB1ABM domain-containing protein. (360 aa)
EPB41L3Erythrocyte membrane protein band 4.1 like 3. (1367 aa)
MATN2Matrilin 2. (1297 aa)
GAPDHGlyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
CCDC89Coiled-coil domain containing 89. (366 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
FNIP1Folliculin-interacting protein 1; May act as a co-chaperone of HSP90AA1. May inhibit the ATPase activity of HSP90AA1 leading to reduction in its chaperone activity. May be involved in energy and/or nutrient sensing. Belongs to the FNIP family. (1170 aa)
CACUL1Cullin domain-containing protein; Belongs to the cullin family. (377 aa)
GMCL1BTB domain-containing protein. (721 aa)
KLHL15Kelch-like protein 15; Substrate-specific adapter for CUL3 E3 ubiquitin-protein ligase complex. (604 aa)
CUL2CULLIN_2 domain-containing protein; Belongs to the cullin family. (774 aa)
TOR1AIP2Torsin 1A interacting protein 2. (509 aa)
CUL4BCullin 4B; Belongs to the cullin family. (883 aa)
CDK5R1Cyclin dependent kinase 5 regulatory subunit 1. (300 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
FBXO38F-box protein 38. (1186 aa)
CUL5Cullin 5; Belongs to the cullin family. (662 aa)
FEM1BProtein fem-1 homolog B; Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis (By similarity); Belongs to the fem-1 family. (627 aa)
KLHDC2Uncharacterized protein. (407 aa)
CUL4ACullin 4A; Belongs to the cullin family. (767 aa)
BIN1Uncharacterized protein. (442 aa)
KLHL8Kelch like family member 8. (617 aa)
KLHDC10Kelch domain containing 10. (409 aa)
PGK2Phosphoglycerate kinase; Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility. (417 aa)
DCAF12L2DDB1- and CUL4-associated factor 12; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. (427 aa)
APPBP2TPR_REGION domain-containing protein. (586 aa)
CUL3Cullin 3; Belongs to the cullin family. (768 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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