(7 nodes) (2023) The Abeta42 Peptide and IAPP Physically Interact in a Yeast-Based Assay. network (Gallus gallus)

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Predicted Interactions

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Your Input:
	TARDBP	TAR DNA-binding protein 43; Probably involved in transcriptional repression (By similarity). May play a role in the maintenance of the circadian clock periodicity (By similarity). (414 aa)
	SNCA	Alpha-synuclein; Belongs to the synuclein family. (143 aa)
	IAPP	Amyloid protein. (135 aa)
	HTT	Huntingtin. (3095 aa)
	PXDN	Peroxidasin. (1611 aa)
	PRNP	Major prion protein homolog; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its h [...] (273 aa)
	PXDNL	Uncharacterized protein. (1406 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HTT	IAPP	ENSGALP00000025163	ENSGALP00000021476	Huntingtin.	Amyloid protein.	0.427
HTT	PRNP	ENSGALP00000025163	ENSGALP00000040285	Huntingtin.	Major prion protein homolog; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its h [...]	0.631
HTT	SNCA	ENSGALP00000025163	ENSGALP00000067652	Huntingtin.	Alpha-synuclein; Belongs to the synuclein family.	0.937
HTT	TARDBP	ENSGALP00000025163	ENSGALP00000004576	Huntingtin.	TAR DNA-binding protein 43; Probably involved in transcriptional repression (By similarity). May play a role in the maintenance of the circadian clock periodicity (By similarity).	0.892
IAPP	HTT	ENSGALP00000021476	ENSGALP00000025163	Amyloid protein.	Huntingtin.	0.427
IAPP	PRNP	ENSGALP00000021476	ENSGALP00000040285	Amyloid protein.	Major prion protein homolog; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its h [...]	0.709
IAPP	SNCA	ENSGALP00000021476	ENSGALP00000067652	Amyloid protein.	Alpha-synuclein; Belongs to the synuclein family.	0.768
PRNP	HTT	ENSGALP00000040285	ENSGALP00000025163	Major prion protein homolog; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its h [...]	Huntingtin.	0.631
PRNP	IAPP	ENSGALP00000040285	ENSGALP00000021476	Major prion protein homolog; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its h [...]	Amyloid protein.	0.709
PRNP	SNCA	ENSGALP00000040285	ENSGALP00000067652	Major prion protein homolog; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its h [...]	Alpha-synuclein; Belongs to the synuclein family.	0.922
PRNP	TARDBP	ENSGALP00000040285	ENSGALP00000004576	Major prion protein homolog; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its h [...]	TAR DNA-binding protein 43; Probably involved in transcriptional repression (By similarity). May play a role in the maintenance of the circadian clock periodicity (By similarity).	0.741
PXDN	PXDNL	ENSGALP00000026363	ENSGALP00000049777	Peroxidasin.	Uncharacterized protein.	0.696
PXDN	SNCA	ENSGALP00000026363	ENSGALP00000067652	Peroxidasin.	Alpha-synuclein; Belongs to the synuclein family.	0.515
PXDNL	PXDN	ENSGALP00000049777	ENSGALP00000026363	Uncharacterized protein.	Peroxidasin.	0.696
PXDNL	SNCA	ENSGALP00000049777	ENSGALP00000067652	Uncharacterized protein.	Alpha-synuclein; Belongs to the synuclein family.	0.532
SNCA	HTT	ENSGALP00000067652	ENSGALP00000025163	Alpha-synuclein; Belongs to the synuclein family.	Huntingtin.	0.937
SNCA	IAPP	ENSGALP00000067652	ENSGALP00000021476	Alpha-synuclein; Belongs to the synuclein family.	Amyloid protein.	0.768
SNCA	PRNP	ENSGALP00000067652	ENSGALP00000040285	Alpha-synuclein; Belongs to the synuclein family.	Major prion protein homolog; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its h [...]	0.922
SNCA	PXDN	ENSGALP00000067652	ENSGALP00000026363	Alpha-synuclein; Belongs to the synuclein family.	Peroxidasin.	0.515
SNCA	PXDNL	ENSGALP00000067652	ENSGALP00000049777	Alpha-synuclein; Belongs to the synuclein family.	Uncharacterized protein.	0.532