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| | OTOGL | Otogelin like. (2267 aa) |
| | USH2A | Usherin. (5190 aa) |
| | DLX5 | Homeobox protein DLX-5; Transcriptional factor involved in bone development. Could be involved in apical ectodermal ridge activity, pattern formation, and cartilage differentiation. Binds to DNA; Belongs to the distal-less homeobox family. (286 aa) |
| | NEUROD1 | Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. (357 aa) |
| | CTAGE1 | Otoraplin; Belongs to the MIA/OTOR family. (132 aa) |
| | VIM | Vimentin; Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. (460 aa) |
| | LHX5 | LIM homeobox protein 5. (402 aa) |
| | NEFH | Neurofilament heavy; Belongs to the intermediate filament family. (947 aa) |
| | FGF16 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | TFAP2C | Transcription factor AP-2 gamma. (448 aa) |
| | BMP7 | Bone morphogenetic protein 7. (465 aa) |
| | FGF4 | Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Required for normal limb development during embryogenesis (By similarity). (194 aa) |
| | SHH | Sonic hedgehog protein N-product; [Sonic hedgehog protein]: The C-terminal part of the sonic hedgehog protein precursor displays an autoproteolysis and a cholesterol transferase activity (By similarity). Both activities result in the cleavage of the full-length protein into two parts (ShhN and ShhC) followed by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated ShhN (By similarity). Both activities occur in the reticulum endoplasmic (By similarity). Once cleaved, ShhC is degraded in the endoplasmic reticulum (By similarity). (425 aa) |
| | USH1C | USH1 protein network component harmonin. (556 aa) |
| | TWIST2 | Dermo protein. (160 aa) |
| | PRDM12 | PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; Belongs to the class V-like SAM-binding methyltransferase superfamily. (351 aa) |
| | KRT13 | IF rod domain-containing protein; Belongs to the intermediate filament family. (463 aa) |
| | VTN | SMB domain-containing protein. (453 aa) |
| | OCM | Parvalbumin, thymic CPV3; Binds two calcium ions. (109 aa) |
| | LMX1A | Uncharacterized protein. (380 aa) |
| | PRRX1 | Paired mesoderm homeobox protein 1; May participate in maintenance of mesenchymal cell lineages derived from both mesoderm and the neural crest and in patterning of the limbs and the face. (245 aa) |
| | NKX2-5 | Homeobox protein Nkx-2.5; Implicated in commitment to and/or differentiation of the myocardial lineage. Binds to the core DNA motif of promoter. Belongs to the NK-2 homeobox family. (294 aa) |
| | PCDH15 | Protocadherin-15; Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function (By similarity). (2192 aa) |
| | NOTCH1 | Uncharacterized protein. (2561 aa) |
| | MEOX1 | Homeobox domain-containing protein. (240 aa) |
| | WNT3 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (355 aa) |
| | ESPN | WH2 domain-containing protein. (371 aa) |
| | NEFM | Neurofilament medium polypeptide; Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. (858 aa) |
| | PLP1 | Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin; Belongs to the myelin proteolipid protein family. (277 aa) |
| | GABRP | Gamma-aminobutyric acid type A receptor pi subunit; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (445 aa) |
| | USH1C-2 | Uncharacterized protein. (128 aa) |
| | DUSP6 | Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (388 aa) |
| | PAX6 | Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development. (500 aa) |
| | WNT1 | Protein Wnt-1; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. Developmental protein that promotes cell proliferation in the developing spinal cord. Has a role in osteoblast function, bone development and bone homeostasis (By similarity). (550 aa) |
| | SMOC2 | SPARC related modular calcium binding 2. (441 aa) |
| | OTX1 | Orthodenticle homeobox 1. (335 aa) |
| | FGF11 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (225 aa) |
| | PCP4 | Purkinje cell protein 4. (55 aa) |
| | MYO7A | Myosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2183 aa) |
| | TNNI1 | Troponin I1, slow skeletal type. (189 aa) |
| | MYO15A | Uncharacterized protein. (807 aa) |
| | NRARP | NOTCH regulated ankyrin repeat protein. (124 aa) |
| | DACH1 | Ski_Sno domain-containing protein. (712 aa) |
| | ANXA4 | Annexin. (350 aa) |
| | FGF10 | Uncharacterized protein. (261 aa) |
| | GDF7 | Growth differentiation factor 7. (400 aa) |
| | FGF5 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (292 aa) |
| | APCDD1 | Protein APCDD1; Negative regulator of the Wnt signaling pathway. Inhibits Wnt signaling in a cell-autonomous manner and functions upstream of beta- catenin. (515 aa) |
| | ITGA8 | Integrin alpha-8 heavy chain; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1, TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis (By similarity). Neuronal receptor for TNC it mediates cell- cell interactions and regulates neurite outgrowth of sensory and motor neurons. (1076 aa) |
| | DLX3 | Homeobox domain-containing protein. (451 aa) |
| | EMX2 | Empty spiracles homeobox 2. (336 aa) |
| | HES6 | Hes family bHLH transcription factor 6. (242 aa) |
| | NRXN3 | Neurexin-3; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity). (1693 aa) |
| | CRYM | Crystallin mu. (252 aa) |
| | CTSE | Cathepsin E; Belongs to the peptidase A1 family. (353 aa) |
| | KRT24 | Keratin, type I cytoskeletal 19; Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle (By similarity). (423 aa) |
| | NEFL | Neurofilament light; Belongs to the intermediate filament family. (373 aa) |
| | ACTC1 | Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa) |
| | SPARCL1 | SPARC like 1. (658 aa) |
| | PDGFA | Platelet-derived growth factor A chain long form; Belongs to the PDGF/VEGF growth factor family. (211 aa) |
| | MYH1B | Myosin-1B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1944 aa) |
| | S100A13 | S100 calcium binding protein A13; Belongs to the S-100 family. (96 aa) |
| | COL1A1 | Collagen alpha-1(I) chain; Type I collagen is a member of group I collagen (fibrillar forming collagen). (1453 aa) |
| | ZIC5 | Zic family member 5. (495 aa) |
| | TBX2 | T-box transcription factor 2. (693 aa) |
| | NEUROG1 | Neurogenin 1. (179 aa) |
| | PAX3 | Paired-box transcription factor protein PAX3. (484 aa) |
| | KRT17 | IF rod domain-containing protein; Belongs to the intermediate filament family. (559 aa) |
| | ELAVL4 | ELAV-like protein; Belongs to the RRM elav family. (402 aa) |
| | CDH23 | Cadherin related 23. (1378 aa) |
| | ID4 | BHLH domain-containing protein. (139 aa) |
| | SNAI2 | Uncharacterized protein. (258 aa) |
| | STMN2 | Stathmin-2; Is a key regulator of neurite extension through regulation of microtubule instabilily. (179 aa) |
| | IRX1 | Homeobox domain-containing protein. (467 aa) |
| | IGFBP3 | Uncharacterized protein. (337 aa) |
| | KRT5 | Type II alpha-keratin IIA; Belongs to the intermediate filament family. (599 aa) |
| | GFI1 | Growth factor independent 1 transcriptional repressor. (405 aa) |
| | POU4F3-2 | Brain-specific homeobox/POU domain protein 3; May play a role in specifying terminally differentiated neuronal phenotypes; Belongs to the POU transcription factor family. Class-4 subfamily. (341 aa) |
| | FGF18 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | FOXG1 | Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes. (451 aa) |
| | ZIC2 | Zinc finger protein Zic2. (478 aa) |
| | FBXO2 | F-box protein 2. (247 aa) |
| | FGF13 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa) |
| | FMN1 | Formin; Is important for morphogenesis of limb and kidney and may be involved in determining dorsoventral neural tube polarity and motor neuron induction. It may also have a function in differentiated cells or be involved in maintaining specific differentiated states. (1437 aa) |
| | KRT18 | Keratin 18; Belongs to the intermediate filament family. (427 aa) |
| | GBX2 | Homeobox protein GBX-2; May act as a transcription factor for cell pluripotency and differentiation in the embryo. (339 aa) |
| | EYA1 | Eyes absent homolog 1; Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for other transcription factors of this family. Tyrosine phosphatase that dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function i [...] (625 aa) |
| | SPRY1 | Protein sprouty homolog 1; May function as an antagonist of fibroblast growth factor (FGF) pathways and may negatively modulate respiratory organogenesis; Belongs to the sprouty family. (321 aa) |
| | TUBB3 | Tubulin beta-4 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (496 aa) |
| | ERBB3 | Protein kinase domain-containing protein. (1319 aa) |
| | FGF12 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (243 aa) |
| | COL5A1 | Fibrillar collagen NC1 domain-containing protein. (1835 aa) |
| | COL3A1 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. (1460 aa) |
| | POU4F3 | POU domain protein. (326 aa) |
| | HHIP | Hedgehog interacting protein. (697 aa) |
| | BMPER | Crossveinless-2. (678 aa) |
| | POU3F4 | POU domain protein. (247 aa) |
| | OTOG | CTCK domain-containing protein. (468 aa) |
| | CIB2 | Uncharacterized protein. (203 aa) |
| | FGF22 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (176 aa) |
| | MSX2 | Homeobox protein MSX-2; Acts as a transcriptional regulator in bone development. Binds to DNA (By similarity). Morphogenetic role; Belongs to the Msh homeobox family. (259 aa) |
| | SALL4 | Uncharacterized protein. (1108 aa) |
| | SIX1 | Sine oculis-related homeobox 1 homolog. (282 aa) |
| | OC90 | Otoconin. (524 aa) |
| | SOX2 | Transcription factor SOX-2; Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development. (312 aa) |
| | LHFPL5 | LHFPL tetraspan subfamily member 5 protein. (221 aa) |
| | OTX2 | Homeodomain transcription factor. (289 aa) |
| | PAX2 | Paired-box containing protein Pax-2. (394 aa) |
| | MPZ | Myelin protein P0; Is an adhesion molecule necessary for normal myelination in the peripheral nervous system. It mediates adhesion between adjacent myelin wraps and ultimately drives myelin compaction. (249 aa) |
| | CABP2 | Uncharacterized protein. (215 aa) |
| | TWIST1 | CTwist. (190 aa) |
| | WNT2B | Protein Wnt-2b; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Acts as an upstream regulator of FGF10 in the lateral plate mesoderm during limb initiation in the embryo. (385 aa) |
| | FAM65B | Rho family-interacting cell polarization regulator 2; Acts as an inhibitor of the small GTPase RHOA and plays several roles in the regulation of myoblast and hair cell differentiation, lymphocyte T proliferation and neutrophil polarization. Plays a role in fetal mononuclear myoblast differentiation by promoting filopodia and myotube formation. Maintains naive T lymphocytes in a quiescent state and prevents chemokine-induced T lymphocyte responses, such as cell adhesion, polarization and migration. Involved also in the regulation of neutrophil polarization, chemotaxis and adhesion. Requ [...] (1067 aa) |
| | SOX17 | Uncharacterized protein. (410 aa) |
| | COL17A1 | 120 kDa linear IgA disease antigen homolog; May play a role in the integrity of hemidesmosome and the attachment of basal keratinocytes to the underlying basement membrane. (1510 aa) |
| | GPM6A | Neuronal proteolipid GPM6A. (278 aa) |
| | BAMBI | BMP and activin membrane-bound inhibitor homolog; Negatively regulates TGF-beta signaling. Belongs to the BAMBI family. (259 aa) |
| | FGF19 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (224 aa) |
| | TPBG | Trophoblast glycoprotein. (225 aa) |
| | ISL1 | Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...] (349 aa) |
| | FGF7 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa) |
| | FGF3 | Fibroblast growth factor 3; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Belongs to the heparin-binding growth factors family. (220 aa) |
| | HES6-2 | Uncharacterized protein. (227 aa) |
| | FGF23 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (254 aa) |
| | PRRX2 | Paired mesoderm homeobox protein 2; May play a role in development of the heart; Belongs to the paired homeobox family. (247 aa) |
| | MYH1D | Myosin-1B; Muscle contraction. (1940 aa) |
| | NHLH1 | BHLH domain-containing protein. (130 aa) |
| | FOXE3 | Forkhead box protein D3; Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri- implantation stages of embryogenesis. (386 aa) |
| | S100A10 | Protein S100-A10; Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. (97 aa) |
| | FGF9 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (213 aa) |
| | GADD45G | Growth arrest and DNA-damage-inducible protein 45 gamma. (159 aa) |
| | ELAVL2 | ELAV-like protein; Belongs to the RRM elav family. (450 aa) |
| | ANKFN1 | Ankyrin repeat and fibronectin type III domain containing 1. (1079 aa) |
| | WNT6 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | PHOX2B | Paired like homeobox 2B. (292 aa) |
| | CDH19 | Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (776 aa) |
| | S100B | EF-hand domain-containing protein; Belongs to the S-100 family. (92 aa) |
| | FGF8 | Fibroblast growth factor 8; Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Involved in initiation, outgrowth and patterning of the limbs; Belongs to the heparin-binding growth factors family. (214 aa) |
| | FGF2 | Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis; Belongs to the heparin-binding growth factors family. (158 aa) |
| | MLANA | Melan-A. (113 aa) |
| | CDH6 | Cadherin-6; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. (790 aa) |
| | CLDN10 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (228 aa) |
| | EBF1 | IPT/TIG domain-containing protein. (604 aa) |
| | FGF6 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa) |
| | SPRY2 | Protein sprouty homolog 2; May play an important role in FGF-mediated patterning of the mid/hindbrain region by acting to modulate the signaling effects of FGF8 through participation in a regulatory negative feedback loop. (313 aa) |
| | FGF14 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (253 aa) |
| | OTOF | Otoferlin. (1810 aa) |
| | MYO6 | Unconventional myosin-VI; Myosins are actin-based motor molecules with ATPase activity (By similarity). Unconventional myosins serve in intracellular movements (By similarity). Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments (By similarity). Has slow rate of actin-activated ADP release due to weak ATP binding (By similarity). Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration (By similarity). Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-su [...] (1276 aa) |
| | TBX19 | T-box transcription factor TBX19; May be involved in the initial formation of the chordamesoderm. (397 aa) |
| | ALDH1A1 | Retinal dehydrogenase 1; Can convert/oxidize retinaldehyde to retinoic acid. Binds free retinal and cellular retinol-binding protein-bound retinal (By similarity). May have a broader specificity and oxidize other aldehydes in vivo (By similarity). (509 aa) |
| | CDH2 | Cadherin-2; Calcium-dependent cell adhesion protein; preferentially mediates homotypic cell-cell adhesion. Cadherins may thus contribute to the sorting of heterogeneous cell types, and thereby play an important role during embryonic development (By similarity). (912 aa) |
| | MSX1 | Homeobox protein GHOX-7; Probably plays a role in patterning events during embryonic limb development. May also be involved in programmed cell death. (288 aa) |
| | VTCN1 | V-set domain containing T cell activation inhibitor 1. (262 aa) |
| | ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif 6. (1119 aa) |
| | FGF20 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa) |
| | DSP | Desmoplakin. (2861 aa) |
| | TFAP2A | TF_AP-2 domain-containing protein. (437 aa) |
| | BMP4 | Bone morphogenetic protein 4; Negatively regulates the structure and function of the limb apical ectodermal ridge. (404 aa) |
| | SOX10 | Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. (461 aa) |
| | TBXT | T-box transcription factor T; Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site. (433 aa) |
| | LUM | Lumican; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily. (343 aa) |
