(12 nodes) (2023) ZBP1 Drives IAV-Induced NLRP3 Inflammasome Activation and Lytic Cell Death, PANoptosis, Independent of the Necroptosis Executioner MLKL. network (Gallus gallus)

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Known Interactions

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Predicted Interactions

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Your Input:
	CASP1	Uncharacterized protein; Belongs to the peptidase C14A family. (540 aa)
	CASP3	Caspase-3; Belongs to the peptidase C14A family. (283 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
	ACTB	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
	CASP18	Initiator caspase; Belongs to the peptidase C14A family. (464 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (267 aa)
	RIPK1	Uncharacterized protein. (682 aa)
	DFNA5	Uncharacterized protein. (505 aa)
	CASP8	Uncharacterized protein; Belongs to the peptidase C14A family. (482 aa)
	CASP7	Caspase 7; Belongs to the peptidase C14A family. (309 aa)
	IL18	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. (198 aa)
	MLKL	Mixed lineage kinase domain like pseudokinase. (486 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTB	CASP1	ENSGALP00000060844	ENSGALP00000070056	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.652
ACTB	CASP18	ENSGALP00000060844	ENSGALP00000065273	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Initiator caspase; Belongs to the peptidase C14A family.	0.752
ACTB	CASP3	ENSGALP00000060844	ENSGALP00000068843	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Caspase-3; Belongs to the peptidase C14A family.	0.995
ACTB	CASP7	ENSGALP00000060844	ENSGALP00000014503	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Caspase 7; Belongs to the peptidase C14A family.	0.953
ACTB	CASP8	ENSGALP00000060844	ENSGALP00000013591	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.759
ACTB	IL18	ENSGALP00000060844	ENSGALP00000012772	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	0.603
ACTB	IL1B	ENSGALP00000060844	ENSGALP00000050171	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Interleukin-1; Belongs to the IL-1 family.	0.861
ACTB	IL6	ENSGALP00000060844	ENSGALP00000068117	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.865
ACTB	MLKL	ENSGALP00000060844	ENSGALP00000004360	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	Mixed lineage kinase domain like pseudokinase.	0.408
CASP1	ACTB	ENSGALP00000070056	ENSGALP00000060844	Uncharacterized protein; Belongs to the peptidase C14A family.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.652
CASP1	CASP18	ENSGALP00000070056	ENSGALP00000065273	Uncharacterized protein; Belongs to the peptidase C14A family.	Initiator caspase; Belongs to the peptidase C14A family.	0.970
CASP1	CASP8	ENSGALP00000070056	ENSGALP00000013591	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.971
CASP1	DFNA5	ENSGALP00000070056	ENSGALP00000017887	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.715
CASP1	IL18	ENSGALP00000070056	ENSGALP00000012772	Uncharacterized protein; Belongs to the peptidase C14A family.	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	0.998
CASP1	IL1B	ENSGALP00000070056	ENSGALP00000050171	Uncharacterized protein; Belongs to the peptidase C14A family.	Interleukin-1; Belongs to the IL-1 family.	0.998
CASP1	IL6	ENSGALP00000070056	ENSGALP00000068117	Uncharacterized protein; Belongs to the peptidase C14A family.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily.	0.856
CASP1	MLKL	ENSGALP00000070056	ENSGALP00000004360	Uncharacterized protein; Belongs to the peptidase C14A family.	Mixed lineage kinase domain like pseudokinase.	0.721
CASP1	RIPK1	ENSGALP00000070056	ENSGALP00000036418	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.592
CASP18	ACTB	ENSGALP00000065273	ENSGALP00000060844	Initiator caspase; Belongs to the peptidase C14A family.	Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA.	0.752
CASP18	CASP1	ENSGALP00000065273	ENSGALP00000070056	Initiator caspase; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.970