STRINGSTRING
SLC39A10 SLC39A10 KRT13 KRT13 VCL VCL SLC9A3R2 SLC9A3R2 TF TF VIPR2 VIPR2 EDNRA EDNRA NR4A3 NR4A3 MAP3K1 MAP3K1 IL17A IL17A GZMK GZMK FOS FOS CCL19-2 CCL19-2 SLC9A3 SLC9A3 NR4A2 NR4A2 GUCY1A1 GUCY1A1 NR4A1 NR4A1 CERS2 CERS2 ADCY8 ADCY8 KCNA6 KCNA6 KRT5 KRT5 TMOD2 TMOD2 KRT17 KRT17 KRT14 KRT14 ACTB ACTB CXCL13 CXCL13 SPON2 SPON2 CD4 CD4 IL6 IL6 CCL19 CCL19 CLASP2 CLASP2 IFNA3 IFNA3 ABLIM3 ABLIM3 TEK TEK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SLC39A10Solute carrier family 39 member 10. (719 aa)
KRT13IF rod domain-containing protein; Belongs to the intermediate filament family. (463 aa)
VCLVinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion; Belongs to the vinculin/alpha-catenin family. (1135 aa)
SLC9A3R2Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (354 aa)
TFOvotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. Responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. There are two forms of hen transferrin, ovotransferrin, found in the ovoducts and, serum transferrin, secreted by the liver. Serum transferrin may also have a role in stimulating cell proliferation and is regulated by iron levels. Ovotransferrin has a bacteriostatic function and, is not controlled by iron levels. (756 aa)
VIPR2VPAC2 receptor; Belongs to the G-protein coupled receptor 2 family. (439 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (421 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (609 aa)
MAP3K1Mitogen-activated protein kinase kinase kinase 1. (1364 aa)
IL17AUncharacterized protein. (169 aa)
GZMKPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (262 aa)
FOSProto-oncogene c-Fos; Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. FOS has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, may activate phospholipid synthesis (By similarity). (367 aa)
CCL19-2SCY domain-containing protein. (99 aa)
SLC9A3Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (830 aa)
NR4A2Nuclear receptor subfamily 4 group A member 2. (605 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (688 aa)
NR4A1Nuclear receptor subfamily 4 group A member 1. (743 aa)
CERS2Ceramide synthase 2. (473 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1240 aa)
KCNA6BTB domain-containing protein; Belongs to the potassium channel family. (613 aa)
KRT5Type II alpha-keratin IIA; Belongs to the intermediate filament family. (599 aa)
TMOD2Tropomodulin 2. (351 aa)
KRT17IF rod domain-containing protein; Belongs to the intermediate filament family. (559 aa)
KRT14Keratin, type I cytoskeletal 14; The nonhelical tail domain is involved in promoting KRT5- KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. (467 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
CXCL13Interleukin-8; Belongs to the intercrine alpha (chemokine CxC) family. (119 aa)
SPON2Spondin 2. (387 aa)
CD4Uncharacterized protein. (487 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
CCL19C-C motif chemokine. (108 aa)
CLASP2Uncharacterized protein. (1506 aa)
IFNA3Interferon. (193 aa)
ABLIM3Actin binding LIM protein family member 3. (768 aa)
TEKTEK receptor tyrosine kinase. (1128 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (14%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.