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NAE1 | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M (By similarity). (535 aa) | ||||
PKLR | Pyruvate kinase PKM; Plays a key role in glycolysis; Belongs to the pyruvate kinase family. (550 aa) | ||||
INSR | Tyrosine-protein kinase receptor. (1324 aa) | ||||
AHR | Uncharacterized protein. (877 aa) | ||||
CUL1 | Cullin 1; Belongs to the cullin family. (776 aa) | ||||
CUL5 | Cullin 5; Belongs to the cullin family. (662 aa) | ||||
ALB | Serum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. (565 aa) | ||||
WEE1 | Wee1-like protein kinase. (641 aa) | ||||
CDKN1B | Cyclin-dependent kinase inhibitor p27 Kip1. (198 aa) | ||||
MMP1 | Matrix metallopeptidase 1. (466 aa) | ||||
RHOB | GTP-binding protein. (196 aa) | ||||
NEDD8 | NEDD8 ubiquitin like modifier. (85 aa) | ||||
MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (483 aa) | ||||
PLEK2 | Uncharacterized protein. (355 aa) | ||||
SNAI1 | Snail like protein. (256 aa) | ||||
CCND1 | G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). (292 aa) | ||||
CUL3 | Cullin 3; Belongs to the cullin family. (768 aa) | ||||
IRS1 | Insulin receptor substrate 1. (1178 aa) | ||||
LOC100859347 | Uncharacterized protein. (964 aa) | ||||
TRAF4 | TNF receptor-associated factor. (470 aa) | ||||
RBX1 | RING-type domain-containing protein. (108 aa) | ||||
UBE2M | Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa) | ||||
UBE2F | NEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5; Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily. (272 aa) | ||||
PLEK | Uncharacterized protein. (353 aa) | ||||
GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa) | ||||
PPARG | Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (498 aa) | ||||
CASP3 | Caspase-3; Belongs to the peptidase C14A family. (283 aa) | ||||
CACUL1 | Cullin domain-containing protein; Belongs to the cullin family. (377 aa) | ||||
FBXO2 | F-box protein 2. (247 aa) | ||||
UBA3 | Ubiquitin like modifier activating enzyme 3. (442 aa) | ||||
COL3A1 | Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. (1460 aa) |