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NAE1 NAE1 PKLR PKLR INSR INSR AHR AHR CUL1 CUL1 CUL5 CUL5 ALB ALB WEE1 WEE1 CDKN1B CDKN1B MMP1 MMP1 RHOB RHOB NEDD8 NEDD8 MDM2 MDM2 PLEK2 PLEK2 SNAI1 SNAI1 CCND1 CCND1 CUL3 CUL3 IRS1 IRS1 LOC100859347 LOC100859347 TRAF4 TRAF4 RBX1 RBX1 UBE2M UBE2M UBE2F UBE2F PLEK PLEK GSK3B GSK3B PPARG PPARG CASP3 CASP3 CACUL1 CACUL1 FBXO2 FBXO2 UBA3 UBA3 COL3A1 COL3A1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NAE1NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M (By similarity). (535 aa)
PKLRPyruvate kinase PKM; Plays a key role in glycolysis; Belongs to the pyruvate kinase family. (550 aa)
INSRTyrosine-protein kinase receptor. (1324 aa)
AHRUncharacterized protein. (877 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
CUL5Cullin 5; Belongs to the cullin family. (662 aa)
ALBSerum albumin; Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood; Belongs to the ALB/AFP/VDB family. (565 aa)
WEE1Wee1-like protein kinase. (641 aa)
CDKN1BCyclin-dependent kinase inhibitor p27 Kip1. (198 aa)
MMP1Matrix metallopeptidase 1. (466 aa)
RHOBGTP-binding protein. (196 aa)
NEDD8NEDD8 ubiquitin like modifier. (85 aa)
MDM2E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (483 aa)
PLEK2Uncharacterized protein. (355 aa)
SNAI1Snail like protein. (256 aa)
CCND1G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). (292 aa)
CUL3Cullin 3; Belongs to the cullin family. (768 aa)
IRS1Insulin receptor substrate 1. (1178 aa)
LOC100859347Uncharacterized protein. (964 aa)
TRAF4TNF receptor-associated factor. (470 aa)
RBX1RING-type domain-containing protein. (108 aa)
UBE2MUbiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa)
UBE2FNEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5; Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily. (272 aa)
PLEKUncharacterized protein. (353 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (498 aa)
CASP3Caspase-3; Belongs to the peptidase C14A family. (283 aa)
CACUL1Cullin domain-containing protein; Belongs to the cullin family. (377 aa)
FBXO2F-box protein 2. (247 aa)
UBA3Ubiquitin like modifier activating enzyme 3. (442 aa)
COL3A1Collagen alpha-1(III) chain; Collagen type III occurs in most soft connective tissues along with type I collagen. (1460 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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