STRINGSTRING
CD34 CD34 PAK1 PAK1 IL10 IL10 STAT3 STAT3 STAT5A STAT5A PGC PGC PLAT PLAT TMEM119 TMEM119 LYVE1 LYVE1 CSF1R CSF1R IRF8 IRF8 TLR4 TLR4 SOCS1 SOCS1 EGR1 EGR1 DLL4 DLL4 CTLA4 CTLA4 IFNG IFNG LGR5 LGR5 HIF1A HIF1A CXCR4 CXCR4 TLR3 TLR3 CD47 CD47 GATA6 GATA6 TGFB2 TGFB2 ANXA1 ANXA1 CD40 CD40 IL4 IL4 PRNP PRNP CX3CL1 CX3CL1 IL34 IL34 SOCS3 SOCS3 SALL1 SALL1 INHBA INHBA CD1B CD1B EGF EGF FABP4 FABP4 STAT1 STAT1 CXCL12 CXCL12 CCR7 CCR7 HGF HGF IL1B IL1B STAT2 STAT2 CXCR1 CXCR1 MERTK MERTK STAT4 STAT4 PTGS2 PTGS2 SMAD7 SMAD7 LGALS3 LGALS3 SMAD2Z SMAD2Z KRAS KRAS CD44 CD44 CX3CR1 CX3CR1 NOS1 NOS1 SMAD3 SMAD3 TIMD4 TIMD4 CD8A-2 CD8A-2 CD38 CD38 CD83 CD83 CD4 CD4 PPARG PPARG IL6 IL6 ZBTB46 ZBTB46 MMP9 MMP9 CD36 CD36 BMP2 BMP2 IFNA3 IFNA3 ZEB2 ZEB2 BMPR1A BMPR1A CD8A-3 CD8A-3 CCR2 CCR2 MYC MYC RUNX3 RUNX3 NOS3 NOS3 CD163 CD163 JAK2 JAK2 LPO LPO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CD34CD34 molecule. (385 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa)
STAT3Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes. (771 aa)
STAT5ASignal transducer and activator of transcription. (764 aa)
PGCPepsinogen C; Belongs to the peptidase A1 family. (389 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (567 aa)
TMEM119Transmembrane protein 119. (245 aa)
LYVE1Link domain-containing protein. (308 aa)
CSF1RUncharacterized protein; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (967 aa)
IRF8Interferon regulatory factor 8; Plays a role as a transcriptional activator or repressor. Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)). Plays a regulatory role in cells of the immune system (By similarity); Belongs to the IRF family. (425 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
SOCS1Suppressor of cytokine signaling 1. (207 aa)
EGR1Early growth response protein 1; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status (By similarity). Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Mediates responses to ischemia and hypoxia; regulates the express [...] (510 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (709 aa)
CTLA4Cytotoxic T-lymphocyte-associated protein 4. (205 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (164 aa)
LGR5Leucine rich repeat containing G protein-coupled receptor 5. (909 aa)
HIF1AHypoxia-inducible factor 1-alpha; Functions as a master transcriptional regulator of the adaptive response to hypoxia. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators (By similarity). (811 aa)
CXCR4G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (362 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (896 aa)
CD47CD47 glycoprotein isoform A. (317 aa)
GATA6Transcription factor GATA-6; Transcriptional activator. (387 aa)
TGFB2Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (412 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (342 aa)
CD40Uncharacterized protein. (299 aa)
IL4Interleukin 4. (136 aa)
PRNPMajor prion protein homolog; Its primary physiological function is unclear. Has cytoprotective activity against internal or environmental stresses. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its h [...] (273 aa)
CX3CL1SCY domain-containing protein. (496 aa)
IL34Interleukin 34. (178 aa)
SOCS3Suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin and leptin receptors (By similarity). Binding to JAK2 inhibits its kinase activity (By similarity). Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Regulates IL-6 [...] (209 aa)
SALL1Uncharacterized protein. (1308 aa)
INHBAInhibin beta A chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. Induces somatostatin in the ciliary ganglion neurons and may [...] (424 aa)
CD1BT-cell surface glycoprotein CD1A2 antigen. (348 aa)
EGFUncharacterized protein. (1283 aa)
FABP4FABP domain-containing protein; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (132 aa)
STAT1Signal transducer and activator of transcription. (755 aa)
CXCL12SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (167 aa)
CCR7C-C chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (374 aa)
HGFHepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily. (726 aa)
IL1BInterleukin-1; Belongs to the IL-1 family. (267 aa)
STAT2Signal transducer and activator of transcription. (961 aa)
CXCR1Putative C-X-C chemokine receptor type 1, CXCR1; Belongs to the G-protein coupled receptor 1 family. (358 aa)
MERTKUncharacterized protein. (990 aa)
STAT4Signal transducer and activator of transcription. (749 aa)
PTGS2Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (652 aa)
SMAD7Mothers against decapentaplegic homolog. (388 aa)
LGALS3Galectin. (258 aa)
SMAD2ZMothers against decapentaplegic homolog. (467 aa)
KRASUncharacterized protein. (189 aa)
CD44Link domain-containing protein. (696 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (354 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1435 aa)
SMAD3Mothers against decapentaplegic homolog 3; Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor- regulated SMAD (R-SMAD) (By similarity). (426 aa)
TIMD4Uncharacterized protein. (611 aa)
CD8A-2Ig-like domain-containing protein. (235 aa)
CD38Uncharacterized protein. (308 aa)
CD83CD83 molecule. (215 aa)
CD4Uncharacterized protein. (487 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (498 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa)
ZBTB46Zinc finger and BTB domain containing 46. (799 aa)
MMP9Uncharacterized protein. (713 aa)
CD36Uncharacterized protein; Belongs to the CD36 family. (471 aa)
BMP2Bone morphogenetic protein 2; Negatively regulates the structure and function of the limb apical ectodermal ridge. (392 aa)
IFNA3Interferon. (193 aa)
ZEB2Smad-interacting protein 1. (1214 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (533 aa)
CD8A-3Ig-like domain-containing protein. (318 aa)
CCR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (354 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (429 aa)
RUNX3RUNX family transcription factor 3. (607 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1402 aa)
CD163Uncharacterized protein. (661 aa)
JAK2Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recru [...] (1165 aa)
LPOUncharacterized protein. (790 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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