STRINGSTRING
EME1 EME1 NSMCE1 NSMCE1 FANCA FANCA BRCA1 BRCA1 FANCD2 FANCD2 DNA2 DNA2 EEF1A2 EEF1A2 FBXO18 FBXO18 FANCM FANCM EEF1A1 EEF1A1 NSMCE3 NSMCE3 ZRANB3-2 ZRANB3-2 NEDD8 NEDD8 CACUL1 CACUL1 NSMCE2 NSMCE2 SLX4 SLX4 CUL1 CUL1 BRIP1 BRIP1 BRCA2 BRCA2 SMC6 SMC6 SMC5 SMC5 FANCC FANCC ZRANB3 ZRANB3 RBX1 RBX1 RPL37A RPL37A EXO1 EXO1 NSMCE4A NSMCE4A FANCI FANCI
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
EME1Essential meiotic structure-specific endonuclease 1. (568 aa)
NSMCE1NSE1 homolog, SMC5-SMC6 complex component. (256 aa)
FANCAFanconi_A_N domain-containing protein. (1653 aa)
BRCA1Uncharacterized protein. (1749 aa)
FANCD2Uncharacterized protein. (1510 aa)
DNA2DNA replication ATP-dependent helicase/nuclease DNA2; Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by [...] (992 aa)
EEF1A2Elongation factor 1-alpha; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (463 aa)
FBXO18F-box DNA helicase 1; 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (By similarity). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Also promotes cell death and DNA double-strand breakage in response to replication stress: p [...] (1021 aa)
FANCMFanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double- stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a mova [...] (2101 aa)
EEF1A1Elongation factor 1-alpha 1; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (473 aa)
NSMCE3MAGE protein. (246 aa)
ZRANB3-2HNH domain-containing protein. (442 aa)
NEDD8NEDD8 ubiquitin like modifier. (85 aa)
CACUL1Cullin domain-containing protein; Belongs to the cullin family. (377 aa)
NSMCE2SP-RING-type domain-containing protein. (239 aa)
SLX4SLX4 structure-specific endonuclease subunit. (1740 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
BRIP1Fanconi anemia group J protein homolog; DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the 'Fanconi anemia' pathway of DNA repair, after FANCD2 ubiquitination. Probably not involved in the repair of DNA double-strand breaks by homologous recombination; Belongs to the DEAD box helicase family. DEAH subfamily. (1252 aa)
BRCA2Tower domain-containing protein. (3397 aa)
SMC6SMC_N domain-containing protein. (1096 aa)
SMC5Structural maintenance of chromosomes protein 5; Core component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Required for recruitment of telomeres to PML nuclear bodies. Required for sister chromatid cohesion during prometaphase and mitotic progression; [...] (1065 aa)
FANCCFanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (559 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (420 aa)
RBX1RING-type domain-containing protein. (108 aa)
RPL37AUncharacterized protein; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (966 aa)
EXO1Uncharacterized protein. (800 aa)
NSMCE4ANon-structural maintenance of chromosomes element 4; Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids. (395 aa)
FANCIUncharacterized protein. (1339 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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