22 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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protein homology

Your Input:
	CYB5B	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family. (144 aa)
	CYP1A2	Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa)
	TFAM	Uncharacterized protein. (262 aa)
	SIRT1	Deacetylase sirtuin-type domain-containing protein. (881 aa)
	CYP3A4	Uncharacterized protein; Belongs to the cytochrome P450 family. (540 aa)
	MFN2	Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (762 aa)
	CYP2C18	Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
	CYP2C23b	Cytochrome P450 2H2; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (491 aa)
	SOD2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
	CYP2D6	Cytochrome P450 CYP2D49; Belongs to the cytochrome P450 family. (502 aa)
	CYB5A	Cytochrome b5; Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases. (138 aa)
	CYP1A1	Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa)
	VDAC1	Uncharacterized protein. (307 aa)
	SIRT3	NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (347 aa)
	CYP1B1	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (536 aa)
	COA6	Cytochrome c oxidase assembly factor 6. (77 aa)
	HTRA2	HtrA serine peptidase 2. (200 aa)
	OPA1	Dynamin-like 120 kDa protein, mitochondrial; Dynamin-related GTPase that is essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission. Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation. The intrinsic GTPase activity is low, and is strongly increased by interaction with lipid membranes (By similarity). Plays a role in remodeling cristae and the release of cytochrome c during apoptosis (By similarity). Belongs to the TRAFAC class dynamin-like GT [...] (1014 aa)
	PRDX3	Peroxiredoxin 3. (309 aa)
	MFN1	Dynamin-type G domain-containing protein; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (740 aa)
	MFF	Mitochondrial fission factor. (252 aa)
	FIS1	Fission, mitochondrial 1. (155 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYB5A	CYP1A1	ENSGALP00000022250	ENSGALP00000039219	Cytochrome b5; Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.	Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	0.516
CYB5A	CYP1A2	ENSGALP00000022250	ENSGALP00000002016	Cytochrome b5; Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.	Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	0.618
CYB5A	CYP2D6	ENSGALP00000022250	ENSGALP00000019386	Cytochrome b5; Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.	Cytochrome P450 CYP2D49; Belongs to the cytochrome P450 family.	0.471
CYB5A	CYP3A4	ENSGALP00000022250	ENSGALP00000007048	Cytochrome b5; Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.408
CYB5B	CYP1A1	ENSGALP00000000933	ENSGALP00000039219	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.	Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	0.564
CYB5B	CYP1A2	ENSGALP00000000933	ENSGALP00000002016	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.	Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	0.597
CYB5B	CYP1B1	ENSGALP00000000933	ENSGALP00000048510	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family.	0.405
CYB5B	CYP2C18	ENSGALP00000000933	ENSGALP00000008773	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.402
CYB5B	CYP2C23b	ENSGALP00000000933	ENSGALP00000009294	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.	Cytochrome P450 2H2; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	0.425
CYB5B	CYP2D6	ENSGALP00000000933	ENSGALP00000019386	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.	Cytochrome P450 CYP2D49; Belongs to the cytochrome P450 family.	0.524
CYP1A1	CYB5A	ENSGALP00000039219	ENSGALP00000022250	Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	Cytochrome b5; Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.	0.516
CYP1A1	CYB5B	ENSGALP00000039219	ENSGALP00000000933	Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.	0.564
CYP1A1	CYP1A2	ENSGALP00000039219	ENSGALP00000002016	Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	0.958
CYP1A1	CYP1B1	ENSGALP00000039219	ENSGALP00000048510	Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family.	0.932
CYP1A1	CYP2C18	ENSGALP00000039219	ENSGALP00000008773	Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.924
CYP1A1	CYP2C23b	ENSGALP00000039219	ENSGALP00000009294	Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	Cytochrome P450 2H2; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	0.562
CYP1A1	CYP2D6	ENSGALP00000039219	ENSGALP00000019386	Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	Cytochrome P450 CYP2D49; Belongs to the cytochrome P450 family.	0.560
CYP1A1	CYP3A4	ENSGALP00000039219	ENSGALP00000007048	Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	Uncharacterized protein; Belongs to the cytochrome P450 family.	0.960
CYP1A2	CYB5A	ENSGALP00000002016	ENSGALP00000022250	Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	Cytochrome b5; Cytochrome b5 is a membrane-bound hemoprotein functioning as an electron carrier for several membrane-bound oxygenases.	0.618
CYP1A2	CYB5B	ENSGALP00000002016	ENSGALP00000000933	Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.	Cytochrome b5 heme-binding domain-containing protein; Belongs to the cytochrome b5 family.	0.597