(9 nodes) (1998) Tolerant B lymphocytes acquire resistance to Fas-mediated apoptosis after treatment with interleukin 4 but not after treatment with specific antigen unless a surface immunoglobulin threshold is exceeded. network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CD4	Uncharacterized protein. (487 aa)
	CD8A-2	Ig-like domain-containing protein. (235 aa)
	LGALS3	Galectin. (258 aa)
	IGF2	Insulin-like growth factor II; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for integrin which is required for IGF2 signaling. (187 aa)
	IL4	Interleukin 4. (136 aa)
	CD40LG	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Induces the activation of NF-kappa-B (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity). Belongs to the tumor necrosis factor family. (272 aa)
	BCR	BCR activator of RhoGEF and GTPase. (1351 aa)
	CD40	Uncharacterized protein. (299 aa)
	CD8A-3	Ig-like domain-containing protein. (318 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	CD40	ENSGALP00000065611	ENSGALP00000038316	Uncharacterized protein.	Uncharacterized protein.	0.960
CD4	CD40LG	ENSGALP00000065611	ENSGALP00000010340	Uncharacterized protein.	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Induces the activation of NF-kappa-B (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity). Belongs to the tumor necrosis factor family.	0.978
CD4	CD8A-2	ENSGALP00000065611	ENSGALP00000059832	Uncharacterized protein.	Ig-like domain-containing protein.	0.984
CD4	CD8A-3	ENSGALP00000065611	ENSGALP00000071819	Uncharacterized protein.	Ig-like domain-containing protein.	0.982
CD4	IL4	ENSGALP00000065611	ENSGALP00000039130	Uncharacterized protein.	Interleukin 4.	0.979
CD4	LGALS3	ENSGALP00000065611	ENSGALP00000055146	Uncharacterized protein.	Galectin.	0.847
CD40	CD4	ENSGALP00000038316	ENSGALP00000065611	Uncharacterized protein.	Uncharacterized protein.	0.960
CD40	CD40LG	ENSGALP00000038316	ENSGALP00000010340	Uncharacterized protein.	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Induces the activation of NF-kappa-B (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity). Belongs to the tumor necrosis factor family.	0.999
CD40	CD8A-2	ENSGALP00000038316	ENSGALP00000059832	Uncharacterized protein.	Ig-like domain-containing protein.	0.951
CD40	CD8A-3	ENSGALP00000038316	ENSGALP00000071819	Uncharacterized protein.	Ig-like domain-containing protein.	0.951
CD40	IL4	ENSGALP00000038316	ENSGALP00000039130	Uncharacterized protein.	Interleukin 4.	0.951
CD40	LGALS3	ENSGALP00000038316	ENSGALP00000055146	Uncharacterized protein.	Galectin.	0.615
CD40LG	CD4	ENSGALP00000010340	ENSGALP00000065611	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Induces the activation of NF-kappa-B (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity). Belongs to the tumor necrosis factor family.	Uncharacterized protein.	0.978
CD40LG	CD40	ENSGALP00000010340	ENSGALP00000038316	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Induces the activation of NF-kappa-B (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity). Belongs to the tumor necrosis factor family.	Uncharacterized protein.	0.999
CD40LG	CD8A-2	ENSGALP00000010340	ENSGALP00000059832	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Induces the activation of NF-kappa-B (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity). Belongs to the tumor necrosis factor family.	Ig-like domain-containing protein.	0.884
CD40LG	CD8A-3	ENSGALP00000010340	ENSGALP00000071819	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Induces the activation of NF-kappa-B (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity). Belongs to the tumor necrosis factor family.	Ig-like domain-containing protein.	0.872
CD40LG	IL4	ENSGALP00000010340	ENSGALP00000039130	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Induces the activation of NF-kappa-B (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity). Belongs to the tumor necrosis factor family.	Interleukin 4.	0.855
CD8A-2	CD4	ENSGALP00000059832	ENSGALP00000065611	Ig-like domain-containing protein.	Uncharacterized protein.	0.984
CD8A-2	CD40	ENSGALP00000059832	ENSGALP00000038316	Ig-like domain-containing protein.	Uncharacterized protein.	0.951
CD8A-2	CD40LG	ENSGALP00000059832	ENSGALP00000010340	Ig-like domain-containing protein.	CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Induces the activation of NF-kappa-B (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity). Belongs to the tumor necrosis factor family.	0.884