(12 nodes) Meprin and TRAF homology network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SPOPL	Speckle type BTB/POZ protein like. (392 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (544 aa)
	TRAF1	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
	TRAF4	TNF receptor-associated factor. (470 aa)
	TRIM37	Uncharacterized protein. (983 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (557 aa)
	SPOP	Speckle type BTB/POZ protein. (374 aa)
	MEP1A	Meprin A subunit. (711 aa)
	USP7	Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins, such as p53/TP53. Deubiquitinates p53/TP53, and thereby modulates p53/TP53 stability, p53/TP53-dependent transcription regulation, cell growth repression and apoptosis. May be involved in cell proliferation during early embryonic development (By similarity). (1102 aa)
	MEP1B	Metalloendopeptidase. (827 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SPOP	SPOPL	ENSGALP00000044067	ENSGALP00000066899	Speckle type BTB/POZ protein.	Speckle type BTB/POZ protein like.	0.903
SPOP	USP7	ENSGALP00000044067	ENSGALP00000054732	Speckle type BTB/POZ protein.	Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins, such as p53/TP53. Deubiquitinates p53/TP53, and thereby modulates p53/TP53 stability, p53/TP53-dependent transcription regulation, cell growth repression and apoptosis. May be involved in cell proliferation during early embryonic development (By similarity).	0.412
SPOPL	SPOP	ENSGALP00000066899	ENSGALP00000044067	Speckle type BTB/POZ protein like.	Speckle type BTB/POZ protein.	0.903
SPOPL	TRIM37	ENSGALP00000066899	ENSGALP00000008139	Speckle type BTB/POZ protein like.	Uncharacterized protein.	0.505
SPOPL	USP7	ENSGALP00000066899	ENSGALP00000054732	Speckle type BTB/POZ protein like.	Ubiquitin carboxyl-terminal hydrolase 7; Hydrolase that deubiquitinates target proteins, such as p53/TP53. Deubiquitinates p53/TP53, and thereby modulates p53/TP53 stability, p53/TP53-dependent transcription regulation, cell growth repression and apoptosis. May be involved in cell proliferation during early embryonic development (By similarity).	0.529
TRAF1	TRAF2	ENSGALP00000002401	ENSGALP00000070161	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.936
TRAF1	TRAF3	ENSGALP00000002401	ENSGALP00000066991	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.582
TRAF1	TRAF5	ENSGALP00000002401	ENSGALP00000016021	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.504
TRAF1	TRAF6	ENSGALP00000002401	ENSGALP00000068399	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.703
TRAF2	TRAF1	ENSGALP00000070161	ENSGALP00000002401	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.936
TRAF2	TRAF3	ENSGALP00000070161	ENSGALP00000066991	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.839
TRAF2	TRAF4	ENSGALP00000070161	ENSGALP00000006340	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor.	0.462
TRAF2	TRAF5	ENSGALP00000070161	ENSGALP00000016021	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.963
TRAF2	TRAF6	ENSGALP00000070161	ENSGALP00000068399	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.978
TRAF3	TRAF1	ENSGALP00000066991	ENSGALP00000002401	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.582
TRAF3	TRAF2	ENSGALP00000066991	ENSGALP00000070161	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.839
TRAF3	TRAF5	ENSGALP00000066991	ENSGALP00000016021	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.798
TRAF3	TRAF6	ENSGALP00000066991	ENSGALP00000068399	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.983
TRAF4	TRAF2	ENSGALP00000006340	ENSGALP00000070161	TNF receptor-associated factor.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.462
TRAF4	TRAF6	ENSGALP00000006340	ENSGALP00000068399	TNF receptor-associated factor.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.439