(7 nodes) Caspase recruitment domain network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (418 aa)
	CRADD	Uncharacterized protein. (197 aa)
	CASP2	Caspase-2 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. (441 aa)
	BIRC3	Inhibitor of apoptosis protein; Apoptotic suppressor. (610 aa)
	APAF1	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. (1249 aa)
	CARD8	Uncharacterized protein. (531 aa)
	CASP1	Uncharacterized protein; Belongs to the peptidase C14A family. (540 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APAF1	BIRC3	ENSGALP00000037437	ENSGALP00000035646	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Inhibitor of apoptosis protein; Apoptotic suppressor.	0.649
APAF1	CARD8	ENSGALP00000037437	ENSGALP00000051659	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein.	0.751
APAF1	CASP1	ENSGALP00000037437	ENSGALP00000070056	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.786
APAF1	CASP2	ENSGALP00000037437	ENSGALP00000029853	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase-2 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.	0.912
APAF1	CASP9	ENSGALP00000037437	ENSGALP00000002083	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	Caspase 9; Belongs to the peptidase C14A family.	0.999
BIRC3	APAF1	ENSGALP00000035646	ENSGALP00000037437	Inhibitor of apoptosis protein; Apoptotic suppressor.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.649
BIRC3	CASP1	ENSGALP00000035646	ENSGALP00000070056	Inhibitor of apoptosis protein; Apoptotic suppressor.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.583
BIRC3	CASP2	ENSGALP00000035646	ENSGALP00000029853	Inhibitor of apoptosis protein; Apoptotic suppressor.	Caspase-2 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.	0.592
BIRC3	CASP9	ENSGALP00000035646	ENSGALP00000002083	Inhibitor of apoptosis protein; Apoptotic suppressor.	Caspase 9; Belongs to the peptidase C14A family.	0.983
CARD8	APAF1	ENSGALP00000051659	ENSGALP00000037437	Uncharacterized protein.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.751
CARD8	CASP1	ENSGALP00000051659	ENSGALP00000070056	Uncharacterized protein.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.660
CARD8	CASP9	ENSGALP00000051659	ENSGALP00000002083	Uncharacterized protein.	Caspase 9; Belongs to the peptidase C14A family.	0.938
CASP1	APAF1	ENSGALP00000070056	ENSGALP00000037437	Uncharacterized protein; Belongs to the peptidase C14A family.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.786
CASP1	BIRC3	ENSGALP00000070056	ENSGALP00000035646	Uncharacterized protein; Belongs to the peptidase C14A family.	Inhibitor of apoptosis protein; Apoptotic suppressor.	0.583
CASP1	CARD8	ENSGALP00000070056	ENSGALP00000051659	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.660
CASP1	CASP9	ENSGALP00000070056	ENSGALP00000002083	Uncharacterized protein; Belongs to the peptidase C14A family.	Caspase 9; Belongs to the peptidase C14A family.	0.438
CASP2	APAF1	ENSGALP00000029853	ENSGALP00000037437	Caspase-2 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.912
CASP2	BIRC3	ENSGALP00000029853	ENSGALP00000035646	Caspase-2 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.	Inhibitor of apoptosis protein; Apoptotic suppressor.	0.592
CASP2	CASP9	ENSGALP00000029853	ENSGALP00000002083	Caspase-2 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival.	Caspase 9; Belongs to the peptidase C14A family.	0.492
CASP9	APAF1	ENSGALP00000002083	ENSGALP00000037437	Caspase 9; Belongs to the peptidase C14A family.	Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP.	0.999