STRINGSTRING
ENSGALP00000065224 ENSGALP00000065224 CRELD1 CRELD1 NPNT NPNT MUC4 MUC4 MATN2 MATN2 NRXN3 NRXN3 FBLN7 FBLN7 LOC107057394 LOC107057394 BCAN BCAN MEP1B MEP1B AGRN AGRN ITGB8 ITGB8 TNC TNC SCUBE1 SCUBE1 PEAR1 PEAR1 TENM1 TENM1 MATN1 MATN1 NRG2 NRG2 LRP1 LRP1 F7 F7 CNTNAP2 CNTNAP2 SCUBE2 SCUBE2 FBN2 FBN2 PTGS2 PTGS2 VWDE VWDE MEGF10 MEGF10 EDIL3 EDIL3 LRP4 LRP4 LRP6 LRP6 FAT3 FAT3 TENM4 TENM4 NID1 NID1 WIF1 WIF1 NRXN1 NRXN1 NELL1 NELL1 HSPG2 HSPG2 HHIP HHIP ENSGALP00000049920 ENSGALP00000049920 EGFL7 EGFL7 UMOD UMOD TMEFF1 TMEFF1 CSPG5 CSPG5 MEP1A MEP1A STAB1 STAB1 LOC414835 LOC414835 CELSR2 CELSR2 ENSGALP00000046379 ENSGALP00000046379 SCARF2 SCARF2 SLIT2 SLIT2 EGF EGF PCSK6 PCSK6 FBN3 FBN3 LRP1B LRP1B NTNG1 NTNG1 GAS6 GAS6 ADAM33 ADAM33 ADAM20-2 ADAM20-2 EYS EYS CCBE1 CCBE1 F10 F10 CLEC18B CLEC18B BTC BTC TGFA TGFA NOTCH2 NOTCH2 NELL2 NELL2 CRB2 CRB2 F1NED6_CHICK F1NED6_CHICK LOC430303 LOC430303 MATN3 MATN3 HABP2 HABP2 ITGBL1 ITGBL1 EGFL6 EGFL6 ATRN ATRN IMPG1 IMPG1 SVEP1 SVEP1 VCAN VCAN HGFAC HGFAC NRG1 NRG1 PROS1 PROS1 THBS4 THBS4 C1S C1S FBLN1 FBLN1 ADAM20 ADAM20 JAG2 JAG2 CFC1 CFC1 F1NA43_CHICK F1NA43_CHICK FAT4 FAT4 HEG1 HEG1 CNTNAP4 CNTNAP4 CNTNAP5 CNTNAP5 DLK1 DLK1 AREG AREG EREG EREG EPGN EPGN LRP2 LRP2 C8A C8A LOC395159 LOC395159 F1NPY9_CHICK F1NPY9_CHICK LRP8 LRP8 MMRN1 MMRN1 DLK2 DLK2 TIE1 TIE1 THBS1 THBS1 LOC424998 LOC424998 JAG1 JAG1 VWA2 VWA2 CUBN CUBN CRELD2 CRELD2 DLL4 DLL4 MALRD1 MALRD1 CD248 CD248 RELN RELN TMEFF2 TMEFF2 MFGE8 MFGE8 F9 F9 FBLN2 FBLN2 PLAU PLAU FBN1 FBN1 ASTN1 ASTN1 BRINP2 BRINP2 OIT3 OIT3 FAT2 FAT2 MATN4 MATN4 EGFLAM EGFLAM PLAT PLAT NTNG2 NTNG2 ADAM9 ADAM9 COMP COMP CNTNAP1 CNTNAP1 DNER DNER NRG4 NRG4 SCUBE3 SCUBE3 NOTCH1 NOTCH1 CRB1 CRB1 HYAL2 HYAL2 PROC PROC HBEGF HBEGF HYAL1 HYAL1 MUC13 MUC13 NAGPA NAGPA PROZ PROZ BRINP3 BRINP3 ADAM23 ADAM23 SELP SELP SLIT3 SLIT3 TNN TNN LTBP1 LTBP1 SNED1 SNED1 ENSGALP00000069344 ENSGALP00000069344 ENSGALP00000068998 ENSGALP00000068998 NCAN NCAN LTBP2 LTBP2 VASN VASN ENSGALP00000068033 ENSGALP00000068033 TENM3 TENM3 HYAL3 HYAL3 ENSGALP00000067795 ENSGALP00000067795 ENSGALP00000067674 ENSGALP00000067674 DLL1 DLL1 LDLR LDLR LOC100859804 LOC100859804 MEGF11 MEGF11 NID2 NID2 TENM2 TENM2 ENSGALP00000073838 ENSGALP00000073838 FAT1 FAT1 LOC112530909 LOC112530909 UMODL1 UMODL1 THBS2 THBS2 ATRNL1 ATRNL1 VLDLR VLDLR ADAM11 ADAM11 STAB2 STAB2 TECTA TECTA TEK TEK ENSGALP00000071979 ENSGALP00000071979 ADAM8 ADAM8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSGALP00000065224Uncharacterized protein. (381 aa)
CRELD1Cysteine rich with EGF like domains 1. (459 aa)
NPNTNephronectin. (593 aa)
MUC4Uncharacterized protein. (3449 aa)
MATN2Matrilin 2. (1297 aa)
NRXN3Neurexin-3; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling (By similarity). (1693 aa)
FBLN7Uncharacterized protein. (444 aa)
LOC107057394Uncharacterized protein. (651 aa)
BCANBrevican. (968 aa)
MEP1BMetalloendopeptidase. (827 aa)
AGRNAgrin C-terminal 110 kDa subunit; [Isoform 1]: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clu [...] (2076 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (787 aa)
TNCTenascin; Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. (2130 aa)
SCUBE1Signal peptide, CUB domain and EGF like domain containing 1. (1011 aa)
PEAR1Uncharacterized protein. (602 aa)
TENM1Teneurin C-terminal-associated peptide; Involved in neural development, regulating the establishment of proper connectivity within the nervous system. May function as a cellular signal transducer (By similarity). [Ten-1 intracellular domain]: Induces gene transcription activation; Belongs to the tenascin family. Teneurin subfamily. (2713 aa)
MATN1Cartilage matrix protein; Cartilage matrix protein is a major component of the extracellular matrix of non-articular cartilage. It binds to collagen. (493 aa)
NRG2Neuregulin 2. (720 aa)
LRP1Low-density lipoprotein receptor-related protein 1; Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an alpha-2-macroglobulin receptor. Belongs to the LDLR family. (4583 aa)
F7Uncharacterized protein. (425 aa)
CNTNAP2Contactin associated protein like 2. (1344 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (931 aa)
FBN2Fibrillin 2. (2903 aa)
PTGS2Prostaglandin G/H synthase 2; Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays imp [...] (652 aa)
VWDEUncharacterized protein. (1285 aa)
MEGF10Multiple EGF like domains 10. (1150 aa)
EDIL3EGF like repeats and discoidin domains 3. (529 aa)
LRP4LDL receptor related protein 4. (1911 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1580 aa)
FAT3Uncharacterized protein. (4598 aa)
TENM4Uncharacterized protein. (2766 aa)
NID1Nidogen 1. (1153 aa)
WIF1Uncharacterized protein. (374 aa)
NRXN1Neurexin-1; Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling. (1503 aa)
NELL1Neural EGFL like 1. (761 aa)
HSPG2Heparan sulfate proteoglycan 2. (3948 aa)
HHIPHedgehog interacting protein. (697 aa)
ENSGALP00000049920Uncharacterized protein. (440 aa)
EGFL7Uncharacterized protein. (275 aa)
UMODZona pellucida protein D. (418 aa)
TMEFF1Uncharacterized protein. (362 aa)
CSPG5Chondroitin sulfate proteoglycan 5, 38 kDa form; May function as a growth and differentiation factor involved in neuritogenesis and more particularly in neurite extension. (812 aa)
MEP1AMeprin A subunit. (711 aa)
STAB1Stabilin 1. (2679 aa)
LOC414835Uncharacterized protein; Cadherins are calcium-dependent cell adhesion proteins. (2819 aa)
CELSR2Cadherin EGF LAG seven-pass G-type receptor 2; Belongs to the G-protein coupled receptor 2 family. (2702 aa)
ENSGALP00000046379Uncharacterized protein. (557 aa)
SCARF2Scavenger receptor class F member 2. (958 aa)
SLIT2Uncharacterized protein. (1533 aa)
EGFUncharacterized protein. (1283 aa)
PCSK6Proprotein convertase subtilisin/kexin type 6; Belongs to the peptidase S8 family. (1024 aa)
FBN3Fibrillin 3. (3009 aa)
LRP1BLDL receptor related protein 1B. (4601 aa)
NTNG1Netrin G1. (483 aa)
GAS6Growth arrest specific 6. (667 aa)
ADAM33Uncharacterized protein. (948 aa)
ADAM20-2Uncharacterized protein. (775 aa)
EYSUncharacterized protein. (806 aa)
CCBE1Collagen and calcium binding EGF domains 1. (329 aa)
F10Activated factor Xa heavy chain; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. VAP cleaves the fusion proteins of Sendai virus, NDV, and influenza virus a at a specific single arginine- containing site, and plays a key role in the viral spreading in the allantoic sac; Belongs to the peptidase S1 family. (475 aa)
CLEC18BUncharacterized protein. (435 aa)
BTCBetacellulin. (171 aa)
TGFAEGF-like domain-containing protein. (156 aa)
NOTCH2Uncharacterized protein. (2432 aa)
NELL2Protein NEL. (816 aa)
CRB2Uncharacterized protein. (1469 aa)
F1NED6_CHICKUncharacterized protein. (165 aa)
LOC430303Uncharacterized protein. (2034 aa)
MATN3Matrilin-3; Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks. (452 aa)
HABP2Uncharacterized protein. (560 aa)
ITGBL1Integrin subunit beta like 1. (490 aa)
EGFL6EGF like domain multiple 6. (370 aa)
ATRNAttractin. (1502 aa)
IMPG1Interphotoreceptor matrix proteoglycan 1; May be involved in a novel system mediating adhesion between neural retina and retinal pigment epithelium. (928 aa)
SVEP1Sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1. (3687 aa)
VCANVersican core protein; May play a role in intercellular signaling and in connecting cells with the extracellular matrix. May take part in the regulation of cell motility, growth and differentiation. Binds hyaluronic acid. (3559 aa)
HGFACHGF activator. (511 aa)
NRG1Pro-neuregulin-1, membrane-bound isoform; Direct ligand for the ERBB tyrosine kinase receptors. The multiple isoforms perform diverse functions: cysteine-rich domain containing isoforms (isoform 2-isoform 4) probably regulate the expression of nicotinic acetylcholine receptors at developing interneuronal synapses. Isoform Ig-NRG is required for the initial induction and/or maintenance of the mature levels of acetylcholine receptors at neuromuscular synapses. Binds to ERBB3 and integrins to form a complex which is essential for NRG1-ERBB signaling (By similarity). (685 aa)
PROS1Protein S. (702 aa)
THBS4Uncharacterized protein. (953 aa)
C1SUncharacterized protein; Belongs to the peptidase S1 family. (701 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes; Belongs to the fibulin family. (704 aa)
ADAM20ADAM metallopeptidase domain 20. (730 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1300 aa)
CFC1Cryptic protein; May play a role in mesoderm and/or neural patterning during gastrulation. (193 aa)
F1NA43_CHICKUncharacterized protein. (1793 aa)
FAT4FAT atypical cadherin 4. (5022 aa)
HEG1EGF-like domain-containing protein. (1714 aa)
CNTNAP4Uncharacterized protein. (1210 aa)
CNTNAP5Contactin-associated protein-like 5; May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication. (1306 aa)
DLK1DLK1. (386 aa)
AREGAmphiregulin. (210 aa)
EREGEGF-like domain-containing protein. (153 aa)
EPGNEpigen; Promotes the growth of epithelial cells. (151 aa)
LRP2LDL receptor related protein 2. (3187 aa)
C8AComplement C8 alpha chain. (603 aa)
LOC395159Schwann cell-specific EGF-like repeat autocrine factor. (211 aa)
F1NPY9_CHICKUncharacterized protein. (484 aa)
LRP8Low-density lipoprotein receptor-related protein 8; Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. Also binds alpha2-macroglobulin. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of th [...] (917 aa)
MMRN1Multimerin 1. (1192 aa)
DLK2Delta like non-canonical Notch ligand 2. (396 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1140 aa)
THBS1Uncharacterized protein. (1175 aa)
LOC424998Uncharacterized protein. (1395 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1216 aa)
VWA2Von Willebrand factor A domain containing 2. (788 aa)
CUBNCubilin. (3634 aa)
CRELD2Uncharacterized protein. (363 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (709 aa)
MALRD1Uncharacterized protein. (2144 aa)
CD248Uncharacterized protein. (556 aa)
RELNReelin; Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity); Belongs to the reel [...] (3462 aa)
TMEFF2Transmembrane protein with EGF like and two follistatin like domains 2. (375 aa)
MFGE8Uncharacterized protein. (474 aa)
F9Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. (471 aa)
FBLN2Fibulin 2. (1196 aa)
PLAUUrokinase-type plasminogen activator chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. (434 aa)
FBN1Fibrillin 1. (2861 aa)
ASTN1Astrotactin 1. (1238 aa)
BRINP2BMP/retinoic acid inducible neural specific 2. (783 aa)
OIT3Oncoprotein induced transcript 3. (550 aa)
FAT2FAT atypical cadherin 2. (4397 aa)
MATN4Matrilin 4. (605 aa)
EGFLAMEGF like, fibronectin type III and laminin G domains. (1026 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (567 aa)
NTNG2Netrin G2. (527 aa)
ADAM9Uncharacterized protein. (847 aa)
COMPUncharacterized protein. (777 aa)
CNTNAP1Contactin associated protein 1. (1306 aa)
DNERDelta/notch like EGF repeat containing. (718 aa)
NRG4EGF-like domain-containing protein. (113 aa)
SCUBE3Signal peptide, CUB domain and EGF like domain containing 3. (976 aa)
NOTCH1Uncharacterized protein. (2561 aa)
CRB1Crumbs cell polarity complex component 1. (807 aa)
HYAL2Hyaluronidase. (478 aa)
PROCUncharacterized protein. (433 aa)
HBEGFProheparin-binding EGF-like growth factor; May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF (By similarity). Plays an important role in the proper development of cranial nerves by inhibiting the migration of the cranial neural crest cells (NCCs) into the odd-numbered neuromeres (r3 and r5) of the hindbrain Plays a role in mediating v-Jun-induced oncogenic tra [...] (212 aa)
HYAL1Hyaluronidase. (436 aa)
MUC13Uncharacterized protein. (627 aa)
NAGPAN-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase. (649 aa)
PROZProtein Z, vitamin K dependent plasma glycoprotein; Belongs to the peptidase S1 family. (358 aa)
BRINP3BMP/retinoic acid inducible neural specific 3. (766 aa)
ADAM23Uncharacterized protein. (844 aa)
SELPUncharacterized protein. (578 aa)
SLIT3Uncharacterized protein. (1641 aa)
TNNTenascin N. (1125 aa)
LTBP1Uncharacterized protein. (1656 aa)
SNED1Sushi, nidogen and EGF like domains 1. (1491 aa)
ENSGALP00000069344Uncharacterized protein. (176 aa)
ENSGALP00000068998EGF-like domain-containing protein. (162 aa)
NCANUncharacterized protein. (1325 aa)
LTBP2Latent transforming growth factor beta binding protein 2. (1851 aa)
VASNVasorin. (695 aa)
ENSGALP00000068033Uncharacterized protein. (527 aa)
TENM3Uncharacterized protein. (2807 aa)
HYAL3Hyaluronidase. (584 aa)
ENSGALP00000067795Uncharacterized protein. (298 aa)
ENSGALP00000067674EGF-like domain-containing protein. (94 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (893 aa)
LDLRUncharacterized protein. (302 aa)
LOC100859804ADAM metallopeptidase domain 32. (693 aa)
MEGF11Multiple EGF like domains 11. (1084 aa)
NID2Uncharacterized protein. (1170 aa)
TENM2Ten-2 intracellular domain; Acts as a ligand of the ADGRL1 receptor (By similarity). Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Promotes the formation of filopodia and enlarged growth cone in neuronal cells. Induces homophilic cell-cell adhesion. May also mediates axon guidance and heterophilic cell-cell adhesion. May function as a cellular signal transducer. (2804 aa)
ENSGALP00000073838EGF-like domain-containing protein. (269 aa)
FAT1FAT atypical cadherin 1. (4645 aa)
LOC112530909Uncharacterized protein. (1657 aa)
UMODL1Uncharacterized protein. (780 aa)
THBS2Thrombospondin-2; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions; Belongs to the thrombospondin family. (1213 aa)
ATRNL1Attractin like 1. (1383 aa)
VLDLRVery low-density lipoprotein receptor; Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity). (894 aa)
ADAM11ADAM metallopeptidase domain 11. (918 aa)
STAB2Stabilin 2. (2550 aa)
TECTAAlpha-tectorin; One of the major non-collagenous components of the tectorial membrane. The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells. Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair- cell membrane potential, transducing sound into electrical signals. (2158 aa)
TEKTEK receptor tyrosine kinase. (1128 aa)
ENSGALP00000071979EGF-like domain-containing protein; Cadherins are calcium-dependent cell adhesion proteins. (329 aa)
ADAM8ADAM metallopeptidase domain 8. (749 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (30%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.