(17 nodes) Toll - interleukin 1 - resistance network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL18RAP	Interleukin 18 receptor accessory protein. (652 aa)
	IL1RAPL1	Interleukin 1 receptor accessory protein like 1. (622 aa)
	TLR3	Toll-like receptor 3; Belongs to the Toll-like receptor family. (896 aa)
	TLR5	TLR5; Belongs to the Toll-like receptor family. (861 aa)
	TLR4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
	TLR1A	TIR domain-containing protein; Belongs to the Toll-like receptor family. (818 aa)
	IL1RL1	Uncharacterized protein. (532 aa)
	TLR2B	Toll-like receptor 2 type-2; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Mediates the response to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (781 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (299 aa)
	IL1R1	Uncharacterized protein. (554 aa)
	IL18R1	Uncharacterized protein. (514 aa)
	TLR2A	Toll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (955 aa)
	IL1RL2	Uncharacterized protein. (584 aa)
	TLR1B	Toll-like receptor 1 type 2; Belongs to the Toll-like receptor family. (652 aa)
	TLR15	TIR domain-containing protein. (924 aa)
	TLR21	TIR domain-containing protein. (1083 aa)
	IL1RAP	Interleukin 1 receptor accessory protein. (795 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL18R1	IL18RAP	ENSGALP00000045685	ENSGALP00000027055	Uncharacterized protein.	Interleukin 18 receptor accessory protein.	0.817
IL18R1	IL1RAP	ENSGALP00000045685	ENSGALP00000073766	Uncharacterized protein.	Interleukin 1 receptor accessory protein.	0.873
IL18R1	MYD88	ENSGALP00000045685	ENSGALP00000042597	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.570
IL18RAP	IL18R1	ENSGALP00000027055	ENSGALP00000045685	Interleukin 18 receptor accessory protein.	Uncharacterized protein.	0.817
IL1R1	IL1RAP	ENSGALP00000045214	ENSGALP00000073766	Uncharacterized protein.	Interleukin 1 receptor accessory protein.	0.974
IL1R1	IL1RL2	ENSGALP00000045214	ENSGALP00000054717	Uncharacterized protein.	Uncharacterized protein.	0.554
IL1R1	MYD88	ENSGALP00000045214	ENSGALP00000042597	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.983
IL1R1	TLR2A	ENSGALP00000045214	ENSGALP00000050968	Uncharacterized protein.	Toll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).	0.409
IL1R1	TLR3	ENSGALP00000045214	ENSGALP00000021914	Uncharacterized protein.	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.446
IL1R1	TLR4	ENSGALP00000045214	ENSGALP00000011319	Uncharacterized protein.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.588
IL1RAP	IL18R1	ENSGALP00000073766	ENSGALP00000045685	Interleukin 1 receptor accessory protein.	Uncharacterized protein.	0.873
IL1RAP	IL1R1	ENSGALP00000073766	ENSGALP00000045214	Interleukin 1 receptor accessory protein.	Uncharacterized protein.	0.974
IL1RAP	IL1RAPL1	ENSGALP00000073766	ENSGALP00000026211	Interleukin 1 receptor accessory protein.	Interleukin 1 receptor accessory protein like 1.	0.486
IL1RAP	IL1RL1	ENSGALP00000073766	ENSGALP00000029597	Interleukin 1 receptor accessory protein.	Uncharacterized protein.	0.971
IL1RAP	IL1RL2	ENSGALP00000073766	ENSGALP00000054717	Interleukin 1 receptor accessory protein.	Uncharacterized protein.	0.871
IL1RAP	MYD88	ENSGALP00000073766	ENSGALP00000042597	Interleukin 1 receptor accessory protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.952
IL1RAPL1	IL1RAP	ENSGALP00000026211	ENSGALP00000073766	Interleukin 1 receptor accessory protein like 1.	Interleukin 1 receptor accessory protein.	0.486
IL1RL1	IL1RAP	ENSGALP00000029597	ENSGALP00000073766	Uncharacterized protein.	Interleukin 1 receptor accessory protein.	0.971
IL1RL1	MYD88	ENSGALP00000029597	ENSGALP00000042597	Uncharacterized protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.645
IL1RL1	TLR5	ENSGALP00000029597	ENSGALP00000015286	Uncharacterized protein.	TLR5; Belongs to the Toll-like receptor family.	0.480