(22 nodes) Breast cancer carboxy-terminal domain network (Gallus gallus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

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Your Input:
	DNTT	DNA nucleotidylexotransferase; Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells. (506 aa)
	FLOT1	Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (876 aa)
	SLF1	SMC5-SMC6 complex localization factor 1. (981 aa)
	CTDP1	CTD phosphatase subunit 1. (1047 aa)
	ENSGALP00000069630	BRCT domain-containing protein. (522 aa)
	REV1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents (By similarity). May play a role in homologous recombination and immunoglobulin gene conversion; Belongs to the DNA polymerase type-Y family. (1276 aa)
	MCPH1	Uncharacterized protein. (589 aa)
	NBN	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recr [...] (753 aa)
	PARP4	Poly [ADP-ribose] polymerase. (1615 aa)
	POLL	DNA polymerase lambda. (844 aa)
	TOPBP1	DNA topoisomerase II binding protein 1. (1519 aa)
	TP53BP1	Tumor protein p53 binding protein 1. (1907 aa)
	PAXIP1	PAX interacting protein 1. (1098 aa)
	PARP1	Poly [ADP-ribose] polymerase 1; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Also mediates serine ADP-ribosylation of target proteins following interaction with HP [...] (1011 aa)
	BARD1	Uncharacterized protein. (795 aa)
	LIG4	DNA ligase 4; Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. (912 aa)
	RFC1	Replication factor C subunit 1. (1147 aa)
	ECT2	Epithelial cell transforming 2. (914 aa)
	DBF4	DBF4 zinc finger. (709 aa)
	PES1	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (584 aa)
	LIG3	DNA ligase. (984 aa)
	BRCA1	Uncharacterized protein. (1749 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BARD1	BRCA1	ENSGALP00000005502	ENSGALP00000004383	Uncharacterized protein.	Uncharacterized protein.	0.999
BARD1	LIG4	ENSGALP00000005502	ENSGALP00000027179	Uncharacterized protein.	DNA ligase 4; Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination.	0.535
BARD1	NBN	ENSGALP00000005502	ENSGALP00000056425	Uncharacterized protein.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recr [...]	0.985
BARD1	PARP1	ENSGALP00000005502	ENSGALP00000038037	Uncharacterized protein.	Poly [ADP-ribose] polymerase 1; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Also mediates serine ADP-ribosylation of target proteins following interaction with HP [...]	0.440
BARD1	PAXIP1	ENSGALP00000005502	ENSGALP00000045622	Uncharacterized protein.	PAX interacting protein 1.	0.844
BARD1	PES1	ENSGALP00000005502	ENSGALP00000012605	Uncharacterized protein.	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.	0.510
BARD1	RFC1	ENSGALP00000005502	ENSGALP00000023075	Uncharacterized protein.	Replication factor C subunit 1.	0.585
BARD1	SLF1	ENSGALP00000005502	ENSGALP00000070108	Uncharacterized protein.	SMC5-SMC6 complex localization factor 1.	0.911
BARD1	TOPBP1	ENSGALP00000005502	ENSGALP00000047284	Uncharacterized protein.	DNA topoisomerase II binding protein 1.	0.987
BARD1	TP53BP1	ENSGALP00000005502	ENSGALP00000047256	Uncharacterized protein.	Tumor protein p53 binding protein 1.	0.811
BRCA1	BARD1	ENSGALP00000004383	ENSGALP00000005502	Uncharacterized protein.	Uncharacterized protein.	0.999
BRCA1	LIG4	ENSGALP00000004383	ENSGALP00000027179	Uncharacterized protein.	DNA ligase 4; Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination.	0.837
BRCA1	MCPH1	ENSGALP00000004383	ENSGALP00000062232	Uncharacterized protein.	Uncharacterized protein.	0.518
BRCA1	NBN	ENSGALP00000004383	ENSGALP00000056425	Uncharacterized protein.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recr [...]	0.955
BRCA1	PARP1	ENSGALP00000004383	ENSGALP00000038037	Uncharacterized protein.	Poly [ADP-ribose] polymerase 1; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. Mainly mediates glutamate and aspartate ADP-ribosylation of target proteins: the ADP-D-ribosyl group of NAD(+) is transferred to the acceptor carboxyl group of glutamate and aspartate residues and further ADP- ribosyl groups are transferred to the 2'-position of the terminal adenosine moiety, building up a polymer with an average chain length of 20-30 units. Also mediates serine ADP-ribosylation of target proteins following interaction with HP [...]	0.863
BRCA1	PAXIP1	ENSGALP00000004383	ENSGALP00000045622	Uncharacterized protein.	PAX interacting protein 1.	0.889
BRCA1	REV1	ENSGALP00000004383	ENSGALP00000066817	Uncharacterized protein.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents (By similarity). May play a role in homologous recombination and immunoglobulin gene conversion; Belongs to the DNA polymerase type-Y family.	0.556
BRCA1	RFC1	ENSGALP00000004383	ENSGALP00000023075	Uncharacterized protein.	Replication factor C subunit 1.	0.583
BRCA1	SLF1	ENSGALP00000004383	ENSGALP00000070108	Uncharacterized protein.	SMC5-SMC6 complex localization factor 1.	0.755
BRCA1	TOPBP1	ENSGALP00000004383	ENSGALP00000047284	Uncharacterized protein.	DNA topoisomerase II binding protein 1.	0.995