STRINGSTRING
DDX49 DDX49 CHD5 CHD5 LOC374195 LOC374195 CHD1L CHD1L RECQL RECQL DHX15 DHX15 CHD4 CHD4 CHD1Z CHD1Z DHX29 DHX29 SKIV2L2 SKIV2L2 DDX21 DDX21 RTEL1 RTEL1 ERCC6 ERCC6 DDX46 DDX46 DDX54 DDX54 ATRX ATRX BLM BLM SKIV2L SKIV2L INO80 INO80 ERCC6L2 ERCC6L2 FANCM FANCM DDX28 DDX28 DDX11 DDX11 WRN WRN LOC423693 LOC423693 HELLS HELLS EP400 EP400 DDX59 DDX59 SMARCA4 SMARCA4 DHX30 DHX30 DDX27 DDX27 DHX58 DHX58 DDX55 DDX55 DDX5 DDX5 SMARCA1 SMARCA1 DDX4 DDX4 POLQ POLQ ASCC3 ASCC3 DDX43 DDX43 DDX3X DDX3X DDX10 DDX10 TTF2 TTF2 DICER1 DICER1 RAD54L RAD54L SMARCA5 SMARCA5 DHX38 DHX38 EIF4A3 EIF4A3 BRIP1 BRIP1 DDX20 DDX20 DDX31 DDX31 DDX6 DDX6 ENSGALP00000048186 ENSGALP00000048186 DQX1 DQX1 DDX17 DDX17 RAD54L2 RAD54L2 DHX36 DHX36 SMARCAD1 SMARCAD1 LOC101748706 LOC101748706 RAD54B RAD54B ENSGALP00000053532 ENSGALP00000053532 CHD2 CHD2 DDX25 DDX25 RP11-529K1.3 RP11-529K1.3 DDX51 DDX51 DDX52 DDX52 DDX23 DDX23 CHD7 CHD7 DDX60 DDX60 SMARCA2 SMARCA2 DDX24 DDX24 HELQ HELQ RPL37A RPL37A DHX35 DHX35 ERCC3 ERCC3 DDX47 DDX47 RECQL5 RECQL5 DDX42 DDX42 YTHDC2 YTHDC2 EIF4A2 EIF4A2 BTAF1 BTAF1 DDX41 DDX41 CHD9 CHD9 DHX8 DHX8 IFIH1 IFIH1 DDX18 DDX18 ERCC6L ERCC6L ZRANB3 ZRANB3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DDX49Uncharacterized protein; Belongs to the DEAD box helicase family. (479 aa)
CHD5Chromodomain helicase DNA binding protein 5. (1966 aa)
LOC374195Uncharacterized protein. (1716 aa)
CHD1LChromodomain helicase DNA binding protein 1 like. (897 aa)
RECQLATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (661 aa)
DHX15Uncharacterized protein. (762 aa)
CHD4Uncharacterized protein. (1145 aa)
CHD1ZChromodomain-helicase-DNA-binding protein 1; ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. Regulates polymerase II transcription. Also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. Regulates negatively DNA replication. Not only involved in transcription-related chromatin remodeling, but also required to maintain a specific chromatin configuration across the genome. Required for maintaini [...] (1808 aa)
DHX29ATP-dependent RNA helicase DHX29; ATP-binding RNA helicase involved in translation initiation. Part of the 43S pre-initiation complex that is required for efficient initiation on mRNAs of higher eukaryotes with structured 5'-UTRs by promoting efficient NTPase-dependent 48S complex formation. Specifically binds to the 40S ribosome near the mRNA entrance. Does not possess a processive helicase activity; Belongs to the DEAD box helicase family. DEAH subfamily. (1372 aa)
SKIV2L2Uncharacterized protein. (1197 aa)
DDX21Uncharacterized protein. (676 aa)
RTEL1Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1307 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1495 aa)
DDX46DEAD-box helicase 46. (1043 aa)
DDX54ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (829 aa)
ATRXATRX chromatin remodeler. (2420 aa)
BLMBloom syndrome protein homolog; ATP-dependent DNA helicase that unwinds single- and double- stranded DNA in a 3'-5' direction. Participates in DNA replication and repair (By similarity). Involved in 5'-end resection of DNA during double-strand break (DSB) repair (By similarity). Negatively regulates sister chromatid exchange (SCE) (By similarity). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (By similarity). Binds DNA. Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction (By similarity). Belongs to the helicase family. R [...] (1380 aa)
SKIV2LSki2 like RNA helicase. (1123 aa)
INO80Uncharacterized protein. (1565 aa)
ERCC6L2ERCC excision repair 6 like 2. (1562 aa)
FANCMFanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double- stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a mova [...] (2101 aa)
DDX28DEAD-box helicase 28. (583 aa)
DDX11DEAD/H-box helicase 11. (908 aa)
WRNUncharacterized protein. (1622 aa)
LOC423693Uncharacterized protein. (712 aa)
HELLSHelicase, lymphoid specific. (822 aa)
EP400E1A binding protein p400. (3029 aa)
DDX59DEAD-box helicase 59. (640 aa)
SMARCA4Uncharacterized protein. (1178 aa)
DHX30ATP-dependent RNA helicase DHX30; RNA-dependent helicase. Plays an important role in the assembly of the mitochondrial large ribosomal subunit. Required for optimal function of the zinc-finger antiviral protein ZC3HAV1. Associates with mitochondrial DNA. Involved in nervous system development and differentiation through its involvement in the up- regulation of a number of genes which are required for neurogenesis, including GSC, NCAM1, neurogenin, and NEUROD. (1232 aa)
DDX27Uncharacterized protein; Belongs to the DEAD box helicase family. (784 aa)
DHX58Uncharacterized protein. (674 aa)
DDX55ATP-dependent RNA helicase DDX55; Probable ATP-binding RNA helicase. (591 aa)
DDX5Uncharacterized protein; Belongs to the DEAD box helicase family. (603 aa)
SMARCA1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (1010 aa)
DDX4Uncharacterized protein; Belongs to the DEAD box helicase family. (663 aa)
POLQDNA polymerase theta. (2489 aa)
ASCC3Activating signal cointegrator 1 complex subunit 3; 3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. (2211 aa)
DDX43Uncharacterized protein; Belongs to the DEAD box helicase family. (438 aa)
DDX3XDEAD-box helicase 3,X-linked; Belongs to the DEAD box helicase family. (651 aa)
DDX10Probable ATP-dependent RNA helicase DDX10; Putative ATP-dependent RNA helicase. (875 aa)
TTF2Helicase ATP-binding domain-containing protein. (1010 aa)
DICER1Endoribonuclease Dicer; Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, al [...] (1921 aa)
RAD54LDNA repair and recombination protein RAD54-like; Involved in DNA repair and mitotic recombination; Belongs to the SNF2/RAD54 helicase family. (804 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1038 aa)
DHX38Uncharacterized protein. (1230 aa)
EIF4A3Eukaryotic initiation factor 4A-III; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the [...] (412 aa)
BRIP1Fanconi anemia group J protein homolog; DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the 'Fanconi anemia' pathway of DNA repair, after FANCD2 ubiquitination. Probably not involved in the repair of DNA double-strand breaks by homologous recombination; Belongs to the DEAD box helicase family. DEAH subfamily. (1252 aa)
DDX20DEAD-box helicase 20; Belongs to the DEAD box helicase family. (767 aa)
DDX31DEAD-box helicase 31; Belongs to the DEAD box helicase family. (495 aa)
DDX6Probable ATP-dependent RNA helicase DDX6; In the process of mRNA degradation, may play a role in mRNA decapping; Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily. (483 aa)
ENSGALP00000048186Uncharacterized protein. (528 aa)
DQX1DEAQ-box RNA dependent ATPase 1. (743 aa)
DDX17DEAD-box helicase 17; Belongs to the DEAD box helicase family. (655 aa)
RAD54L2Uncharacterized protein. (1473 aa)
DHX36DEAH-box helicase 36. (987 aa)
SMARCAD1Uncharacterized protein. (808 aa)
LOC101748706Uncharacterized protein. (2151 aa)
RAD54BDNA repair and recombination protein RAD54B; Involved in DNA repair and mitotic recombination; Belongs to the SNF2/RAD54 helicase family. (918 aa)
ENSGALP00000053532Uncharacterized protein. (512 aa)
CHD2Uncharacterized protein. (1837 aa)
DDX25DEAD-box helicase 25. (579 aa)
RP11-529K1.3Uncharacterized protein. (479 aa)
DDX51DEAD-box helicase 51; Belongs to the DEAD box helicase family. (608 aa)
DDX52Uncharacterized protein. (698 aa)
DDX23DEAD-box helicase 23. (816 aa)
CHD7Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity). (3009 aa)
DDX60DExD/H-box helicase 60. (1821 aa)
SMARCA2Uncharacterized protein. (1594 aa)
DDX24DEAD-box helicase 24. (809 aa)
HELQHelicase, POLQ like. (1048 aa)
RPL37AUncharacterized protein; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (966 aa)
DHX35DEAH-box helicase 35. (712 aa)
ERCC3General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required fo [...] (780 aa)
DDX47Uncharacterized protein; Belongs to the DEAD box helicase family. (453 aa)
RECQL5Uncharacterized protein. (1052 aa)
DDX42ATP-dependent RNA helicase DDX42; ATP-dependent RNA helicase. Binds to RNA. May be involved in the survival of cells (By similarity). (944 aa)
YTHDC2YTH domain containing 2. (1446 aa)
EIF4A2Eukaryotic initiation factor 4A-II; ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity). (390 aa)
BTAF1B-TFIID TATA-box binding protein associated factor 1. (1843 aa)
DDX41Uncharacterized protein. (617 aa)
CHD9Chromodomain helicase DNA binding protein 9. (2820 aa)
DHX8DEAH-box helicase 8. (1163 aa)
IFIH1Uncharacterized protein. (1102 aa)
DDX18RNA helicase. (662 aa)
ERCC6LERCC excision repair 6 like, spindle assembly checkpoint helicase. (1280 aa)
ZRANB3Zinc finger RANBP2-type containing 3. (420 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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