STRINGSTRING
ABL1 ABL1 YES1 YES1 GRB10 GRB10 LYN LYN RAF1 RAF1 STAT1 STAT1 SHC1 SHC1 BTK BTK VAV2 VAV2 PRKCA PRKCA SOCS6 SOCS6 GRAPL GRAPL SH3KBP1 SH3KBP1 RASA1 RASA1 CBLB CBLB TEC TEC EP300 EP300 STAP1 STAP1 KITLG KITLG SOCS5 SOCS5 PIK3CG PIK3CG GRB2 GRB2 SOCS1 SOCS1 CBL CBL CRKL CRKL CLTC CLTC PTPN11 PTPN11 SRC SRC PIK3R2 PIK3R2 STAT5A STAT5A STAT3 STAT3 CISH CISH MAPK3 MAPK3 MAP2K1 MAP2K1 RPS6KA1 RPS6KA1 KIT KIT SPRED2 SPRED2 PRKCB PRKCB DOK1 DOK1 FES FES SOCS4 SOCS4 CRCBL CRCBL AKT1 AKT1 PIK3R1 PIK3R1 HCK HCK MITF MITF PTPRU PTPRU HRAS HRAS JAK2 JAK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ABL1Tyrosine-protein kinase. (1111 aa)
YES1Tyrosine-protein kinase Yes; Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, differentiation, G2/M progression and cytokinesis. (541 aa)
GRB10Uncharacterized protein. (596 aa)
LYNTyrosine-protein kinase. (491 aa)
RAF1RAF proto-oncogene serine/threonine-protein kinase; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions. RAF1 activation initiates a mitogen- activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinases (MAPK3/ERK1 and MAPK1/ERK2) (By similarity). (667 aa)
STAT1Signal transducer and activator of transcription. (755 aa)
SHC1Uncharacterized protein. (626 aa)
BTKTyrosine-protein kinase BTK; Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in close cooperation with the adapter protein B-cell linker prote [...] (684 aa)
VAV2Uncharacterized protein. (844 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (682 aa)
SOCS6Suppressor of cytokine signaling 6. (534 aa)
GRAPLUncharacterized protein. (217 aa)
SH3KBP1Uncharacterized protein. (739 aa)
RASA1Uncharacterized protein. (1120 aa)
CBLBCbl proto-oncogene B. (1025 aa)
TECTyrosine-protein kinase. (630 aa)
EP300E1A binding protein p300. (2450 aa)
STAP1Signal transducing adaptor family member 1. (293 aa)
KITLGProcessed kit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Acts synergistically with other cytokines, probably interleukins (By similarity). (287 aa)
SOCS5Suppressor of cytokine signaling 5. (536 aa)
PIK3CGUncharacterized protein; Belongs to the PI3/PI4-kinase family. (1106 aa)
GRB2Growth factor receptor-bound protein 2; Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway. Belongs to the GRB2/sem-5/DRK family. (217 aa)
SOCS1Suppressor of cytokine signaling 1. (207 aa)
CBLUncharacterized protein. (903 aa)
CRKLCRK like proto-oncogene, adaptor protein. (193 aa)
CLTCClathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family. (1675 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11; This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates (By similarity). May play a positive role during the stages of erythroid cell proliferation. (593 aa)
SRCProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (539 aa)
PIK3R2Uncharacterized protein. (731 aa)
STAT5ASignal transducer and activator of transcription. (764 aa)
STAT3Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes. (771 aa)
CISHCytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...] (258 aa)
MAPK3Mitogen-activated protein kinase. (421 aa)
MAP2K1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (395 aa)
RPS6KA1Ribosomal protein S6 kinase 2 alpha; Serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of transcription. (760 aa)
KITMast/stem cell growth factor receptor Kit; Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine KITLG/SCF and plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. In response to KITLG/SCF binding, KIT can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. Activated KIT also transmits signals via [...] (960 aa)
SPRED2Sprouty related EVH1 domain containing 2. (419 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
DOK1Docking protein 1. (570 aa)
FESFES proto-oncogene, tyrosine kinase. (885 aa)
SOCS4Uncharacterized protein. (436 aa)
CRCBLFibronectin type-III domain-containing protein. (674 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
HCKTyrosine-protein kinase. (514 aa)
MITFBHLH domain-containing protein. (519 aa)
PTPRUReceptor-type tyrosine-protein phosphatase U; Tyrosine-protein phosphatase which dephosphorylates CTNNB1. May function in cell proliferation and migration and play a role in the maintenance of epithelial integrity (By similarity); Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. (1645 aa)
HRASGTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
JAK2Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recru [...] (1165 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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