STRINGSTRING
F13B F13B PLAT PLAT PLG PLG PLAU PLAU F9 F9 F2 F2 FGA FGA FGG FGG SERPINB10 SERPINB10 VWF VWF F11 F11 FGB FGB F10 F10 F8 F8 F5 F5 SERPINF1 SERPINF1 F7 F7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
F13BCoagulation factor XIII B chain. (618 aa)
PLATPlasminogen activator; Belongs to the peptidase S1 family. (567 aa)
PLGPlasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] (802 aa)
PLAUUrokinase-type plasminogen activator chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. (434 aa)
F9Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. (471 aa)
F2Uncharacterized protein; Belongs to the peptidase S1 family. (644 aa)
FGAFibrinogen alpha chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. (741 aa)
FGGFibrinogen C-terminal domain-containing protein. (438 aa)
SERPINB10Serpin family B member 10; Belongs to the serpin family. (412 aa)
VWFUncharacterized protein. (2800 aa)
F11Coagulation factor XI; Belongs to the peptidase S1 family. (608 aa)
FGBFibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. (488 aa)
F10Activated factor Xa heavy chain; Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. VAP cleaves the fusion proteins of Sendai virus, NDV, and influenza virus a at a specific single arginine- containing site, and plays a key role in the viral spreading in the allantoic sac; Belongs to the peptidase S1 family. (475 aa)
F8Coagulation factor VIII; Belongs to the multicopper oxidase family. (2109 aa)
F5Coagulation factor V; Belongs to the multicopper oxidase family. (2025 aa)
SERPINF1SERPIN domain-containing protein; Belongs to the serpin family. (416 aa)
F7Uncharacterized protein. (425 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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