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| | PPP2R3A | EF-hand domain-containing protein. (157 aa) |
| | WNT7B | Protein Wnt-7b; Ligand for members of the frizzled family of seven transmembrane receptors that functions in the canonical Wnt/beta- catenin signaling pathway (By similarity). Required for normal fusion of the chorion and the allantois during placenta development (By similarity). Required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). (353 aa) |
| | WNT4 | Protein Wnt-4; Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Plays an important role in embryonic development (By similarity). (351 aa) |
| | CTNNB1 | Uncharacterized protein. (781 aa) |
| | SOX2 | Transcription factor SOX-2; Transcriptional activator. Binds to the consensus DNA sequence 5'-TCATTGTTGTTG-3'. In cooperation with other transcription factors, binds to the promoter sequence of the crystallin gene to activate transcription in the lens. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation. May function as a switch in neuronal development. (312 aa) |
| | DVL3 | Dishevelled segment polarity protein 3. (731 aa) |
| | WNT2B | Protein Wnt-2b; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta-catenin signaling pathway. Acts as an upstream regulator of FGF10 in the lateral plate mesoderm during limb initiation in the embryo. (385 aa) |
| | MAPK10 | Mitogen-activated protein kinase. (464 aa) |
| | MAP3K7 | Mitogen-activated protein kinase kinase kinase 7. (643 aa) |
| | FZD3 | Frizzled-3; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] (666 aa) |
| | WNT2 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (376 aa) |
| | NANOG | Homeobox protein NANOG; Transcription factor required for the maintenance of pluripotency and self-renewal of embryonic stem cells. Belongs to the Nanog homeobox family. (308 aa) |
| | PRKCA | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (682 aa) |
| | WNT9B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (388 aa) |
| | PRKCI | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (599 aa) |
| | ZBTB33 | Zinc finger and BTB domain containing 33. (688 aa) |
| | WNT6 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa) |
| | JUN | Transcription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated KRAS-mediated transcriptional activation of USP28. May bind to the USP28 promoter; Belongs to the bZIP family. Jun subfamily. (310 aa) |
| | RHOA | GTP-binding protein. (193 aa) |
| | CCND2 | G1/S-specific cyclin-D2; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin D subfamily. (291 aa) |
| | FZD4 | Frizzled-4; Receptor for Wnt proteins (By similarity). Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 ki [...] (525 aa) |
| | CTNND1 | Catenin delta 1. (954 aa) |
| | TCF7 | HMG box domain-containing protein. (397 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa) |
| | NKD1 | NKD inhibitor of WNT signaling pathway 1. (472 aa) |
| | PPP2R5C | Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (580 aa) |
| | NLK | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (527 aa) |
| | CTBP2-2 | Uncharacterized protein. (564 aa) |
| | FZD6 | Frizzled-6; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] (709 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (429 aa) |
| | MAPK9 | Mitogen-activated protein kinase 9; Responds to activation by environmental stress and pro- inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity (By similarity). May play a role in the development of the central nervous system during embryogenesis. May play a role in the regulation of the circadian clock (By similarity); Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. (424 aa) |
| | LEF1 | HMG box domain-containing protein. (412 aa) |
| | AXIN1 | Axin-1; Component of the beta-catenin destruction complex required for regulating CTNNB1 levels through phosphorylation and ubiquitination, and modulating Wnt-signaling. Controls dorsoventral patterning via two opposing effects; down-regulates CTNNB1 to inhibit the Wnt signaling pathway and ventralize embryos, but also dorsalizes embryos by activating a Wnt-independent JNK signaling pathway. (841 aa) |
| | PAFAH1B1 | Lissencephaly-1 homolog; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration. (410 aa) |
| | WNT7A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa) |
| | PLAU | Urokinase-type plasminogen activator chain A; Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. (434 aa) |
| | CCND3 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa) |
| | PRKCD | Protein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (699 aa) |
| | DVL1 | Dishevelled segment polarity protein 1. (529 aa) |
| | PRKCZ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (592 aa) |
| | FBXW2 | Uncharacterized protein. (454 aa) |
| | WNT11 | Protein Wnt-11; Ligand for members of the frizzled family of seven transmembrane receptors. May play a role in the formation of dermal structure, both limb and feather buds. Is likely to signal over only few cell diameters. (354 aa) |
| | PRKCB | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa) |
| | RACGAP1 | Rac GTPase activating protein 1. (638 aa) |
| | WNT16 | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (507 aa) |
| | CD44 | Link domain-containing protein. (696 aa) |
| | AXIN2 | Uncharacterized protein. (837 aa) |
| | CREBBP | CREB binding protein. (2522 aa) |
| | CSNK1E | Casein kinase I isoform epsilon; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Can phosphorylate a large number of proteins. Participates in Wnt signaling. Phosphorylates DVL1. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm (By similarity). (416 aa) |
| | WNT3A | Protein Wnt-3a; [Isoform 1]: Ligand for members of the frizzled family of seven transmembrane receptors (Probable). Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. Regulates chick apical ectodermal ridge formation. Required for normal embryonic mesoderm development and formation of caudal somites. Required for normal morphogenesis of the developing neural tube (By similarity). ECO:0000250|UniProtKB:P56704. (376 aa) |
| | LRP6 | Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1580 aa) |
| | PTPA | Serine/threonine-protein phosphatase 2A activator; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. (321 aa) |
| | FZD7 | Frizzled-7; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to i [...] (567 aa) |
| | PPP2R2A | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (494 aa) |
| | FZD2 | Frizzled-2; Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pa [...] (557 aa) |
| | WNT5B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (436 aa) |
| | APC | APC regulator of WNT signaling pathway. (2853 aa) |
| | PPP2R2C | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (456 aa) |
| | FZD9 | Frizzled-9; Receptor for WNT2 that is coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. (603 aa) |
| | WNT5A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (385 aa) |
| | PPP2R2B | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (459 aa) |
| | CTBP1 | Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (447 aa) |
| | MMP7 | ZnMc domain-containing protein. (267 aa) |
| | PPP2R3B | Uncharacterized protein. (584 aa) |
| | EP300 | E1A binding protein p300. (2450 aa) |
| | PRKCH | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (682 aa) |
| | PPP2R5E | Serine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (467 aa) |
| | WNT10A | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (388 aa) |
| | PPP2CB | Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase; Belongs to the PPP phosphatase family. PP-1 subfamily. (309 aa) |
| | PRKCE | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (743 aa) |
| | PRKD1 | Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (899 aa) |
| | FZD1 | Frizzled-1; Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway. The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes (By similarity). A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK [...] (570 aa) |
| | TCF7L2 | HMG box domain-containing protein. (598 aa) |
| | CCND1 | G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). (292 aa) |
| | PPP2CA | Serine/threonine-protein phosphatase. (309 aa) |
