STRINGSTRING
HEY2 HEY2 JAK2 JAK2 LEF1 LEF1 NCOR2 NCOR2 HIVEP3 HIVEP3 PSEN1 PSEN1 RBPJ RBPJ HEY1 HEY1 ZFPM1 ZFPM1 PIK3R1 PIK3R1 AKT1 AKT1 GSK3B GSK3B CNTFR CNTFR CNTN1 CNTN1 HDAC1 HDAC1 HES4 HES4 PSEN2 PSEN2 SMAD3 SMAD3 HDAC2 HDAC2 SAP30 SAP30 ITCH ITCH KAT2B KAT2B EGFR EGFR FBXW7 FBXW7 SMAD1 SMAD1 TLE1 TLE1 ASCL1 ASCL1 CCN3 CCN3 CUL1 CUL1 SPEN SPEN LFNG LFNG EGF EGF NUMB NUMB CNTF CNTF HES6-2 HES6-2 NFKBIA NFKBIA NOTCH2 NOTCH2 POFUT1 POFUT1 JUN JUN APP APP ADAM17 ADAM17 YY2 YY2 MAML2 MAML2 CIR1 CIR1 JAG2 JAG2 MFNG MFNG RBX1 RBX1 EP300 EP300 SNW1 SNW1 NCSTN NCSTN JAG1 JAG1 DLL4 DLL4 WDR12 WDR12 FURIN FURIN ADAM10 ADAM10 SKP2 SKP2 PIK3R2 PIK3R2 STAT3 STAT3 APH1B APH1B NOTCH1 NOTCH1 SIN3A SIN3A MAPK3 MAPK3 HES5 HES5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HEY2Hes related family bHLH transcription factor with YRPW motif 2. (335 aa)
JAK2Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recru [...] (1165 aa)
LEF1HMG box domain-containing protein. (412 aa)
NCOR2Nuclear receptor corepressor 2. (2464 aa)
HIVEP3Human immunodeficiency virus type I enhancer binding protein 3. (2448 aa)
PSEN1Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa)
RBPJRecombination signal binding protein for immunoglobulin kappa J region. (484 aa)
HEY1Hes related family bHLH transcription factor with YRPW motif 1. (488 aa)
ZFPM1Zinc finger protein, FOG family member 1. (1079 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (480 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
CNTFRCiliary neurotrophic factor receptor subunit alpha; Binds to CNTF (GPA). The alpha subunit provides the receptor specificity. (497 aa)
CNTN1Contactin-1; Mediates cell surface interactions during nervous system development. Interaction with TNR enhances the neurite outgrowth. Belongs to the immunoglobulin superfamily. Contactin family. (1023 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity); Belongs to the histone deacetylase family. HD type 1 subfamily. (480 aa)
HES4Transcription factor HES-1; Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). (290 aa)
PSEN2Presenilin-2 CTF subunit; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement o [...] (455 aa)
SMAD3Mothers against decapentaplegic homolog 3; Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor- regulated SMAD (R-SMAD) (By similarity). (426 aa)
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (489 aa)
SAP30Sin3A associated protein 30. (214 aa)
ITCHE3 ubiquitin-protein ligase. (878 aa)
KAT2BHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (808 aa)
EGFREpidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF and TGFA/TGF-alpha. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues (By similarity). The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades (By similarity). Activates at least 4 major downstream signaling cascades including [...] (1226 aa)
FBXW7Uncharacterized protein. (586 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
TLE1TLE family member 1, transcriptional corepressor. (780 aa)
ASCL1BHLH domain-containing protein. (219 aa)
CCN3CCN family member 3; Immediate-early protein likely to play a role in cell growth regulation. Its overexpression is associated with tumorigenesis and expression of a N-terminal-truncated version of CCN3 gene in chicken embryonic fibroblasts (CEF) is sufficient to induce the transformation of CEF in vitro. (351 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
SPENSpen family transcriptional repressor. (3583 aa)
LFNGBeta-1,3-N-acetylglucosaminyltransferase lunatic fringe; Glycosyltransferase that initiates the elongation of O-linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Essential mediator of somite segmentation and patterning. (363 aa)
EGFUncharacterized protein. (1283 aa)
NUMBPID domain-containing protein. (620 aa)
CNTFCiliary neurotrophic factor; CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. (195 aa)
HES6-2Uncharacterized protein. (227 aa)
NFKBIANF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity). (318 aa)
NOTCH2Uncharacterized protein. (2432 aa)
POFUT1Uncharacterized protein POFUT1. (380 aa)
JUNTranscription factor AP-1; Transcription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. May be involved in activated KRAS-mediated transcriptional activation of USP28. May bind to the USP28 promoter; Belongs to the bZIP family. Jun subfamily. (310 aa)
APPBPTI/Kunitz inhibitor domain-containing protein. (751 aa)
ADAM17Tumor necrosis factor alpha converting enzyme. (829 aa)
YY2Uncharacterized protein. (420 aa)
MAML2Mastermind like transcriptional coactivator 2. (1060 aa)
CIR1Corepressor interacting with RBPJ 1; May modulate splice site selection during alternative splicing of pre-mRNAs. Regulates transcription and acts as corepressor. Recruits repressors to the histone deacetylase complex (HDAC) (By similarity). (460 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1300 aa)
MFNGBeta-1,3-N-acetylglucosaminyltransferase. (352 aa)
RBX1RING-type domain-containing protein. (108 aa)
EP300E1A binding protein p300. (2450 aa)
SNW1SNW domain containing 1. (538 aa)
NCSTNNcstrn_small domain-containing protein. (717 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1216 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (709 aa)
WDR12Ribosome biogenesis protein WDR12; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (455 aa)
FURINTrans Golgi network protease furin; Belongs to the peptidase S8 family. (789 aa)
ADAM10Uncharacterized protein. (749 aa)
SKP2F-box domain-containing protein. (520 aa)
PIK3R2Uncharacterized protein. (731 aa)
STAT3Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes. (771 aa)
APH1BUncharacterized protein. (256 aa)
NOTCH1Uncharacterized protein. (2561 aa)
SIN3AHDAC_interact domain-containing protein. (1274 aa)
MAPK3Mitogen-activated protein kinase. (421 aa)
HES5Hairy and enhancer of split 5. (157 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.