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| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa) |
| | EP300 | E1A binding protein p300. (2450 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (530 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (859 aa) |
| | ORC3 | ORC_WH_C domain-containing protein. (713 aa) |
| | MCM3 | DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (812 aa) |
| | TFDP1 | Transcription factor. (411 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (406 aa) |
| | ATM | Non-specific serine/threonine protein kinase. (3050 aa) |
| | CCND2 | G1/S-specific cyclin-D2; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin D subfamily. (291 aa) |
| | YWHAG | 14-3-3 protein gamma; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity); Belongs to the 14-3-3 family. (247 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (825 aa) |
| | HDAC4 | Histone deacetylase 4; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (1080 aa) |
| | E2F3 | E2F transcription factor 3. (341 aa) |
| | GADD45A | Growth arrest and DNA-damage-inducible protein 45 alpha. (157 aa) |
| | WEE1 | Wee1-like protein kinase. (641 aa) |
| | CCNE2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (405 aa) |
| | E2F5 | E2F_TDP domain-containing protein. (375 aa) |
| | CHEK2 | Uncharacterized protein. (524 aa) |
| | ESPL1 | Extra spindle pole bodies like 1, separase. (2222 aa) |
| | CDKN2A | ARF tumor suppressor. (60 aa) |
| | BUB1B | BUB1 N-terminal domain-containing protein. (1086 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (489 aa) |
| | CDC14B | Uncharacterized protein. (499 aa) |
| | CDC25A | Rhodanese domain-containing protein. (526 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog 3; Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor- regulated SMAD (R-SMAD) (By similarity). (426 aa) |
| | PRKDC | DNA-dependent protein kinase catalytic subunit; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act a [...] (4132 aa) |
| | MAD2L1 | HORMA domain-containing protein. (206 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity); Belongs to the histone deacetylase family. HD type 1 subfamily. (480 aa) |
| | CCNH | Cyclin H; Belongs to the cyclin family. (322 aa) |
| | BUB3 | WD_REPEATS_REGION domain-containing protein. (392 aa) |
| | UBE2F | NEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5; Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily. (272 aa) |
| | ORC5 | AAA_16 domain-containing protein. (459 aa) |
| | RB1 | Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...] (984 aa) |
| | RBL1 | RB transcriptional corepressor like 1. (1050 aa) |
| | HDAC7 | Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1250 aa) |
| | TBC1D8 | TBC1 domain family member 8. (1145 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa) |
| | CDH1 | Cadherin-1; Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. E-cadherin is a ligand for integrin alpha- E/beta-7. (887 aa) |
| | PTTG2 | Uncharacterized protein. (193 aa) |
| | CDC45 | Cell division cycle 45. (566 aa) |
| | E2F4 | E2F transcription factor 4. (414 aa) |
| | HDAC3 | Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (By similarity). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). May play a role in the regulation of the circadian clock in a deacetylase activity-independent manner (By similarity). (428 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2660 aa) |
| | E2F1 | Transcription factor E2F1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA bindi [...] (403 aa) |
| | CDK1 | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle (By similarity). It is required in higher cells for entry into S-phase and mitosis (By similarity). p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). May play a role in regulating the amplitude of the cyclic expression of circadian clock genes (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (303 aa) |
| | CCND3 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa) |
| | SKP2 | F-box domain-containing protein. (520 aa) |
| | ABL1 | Tyrosine-protein kinase. (1111 aa) |
| | CCNB1 | G2/mitotic-specific cyclin-B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition. (399 aa) |
| | MAD1L1 | Mitotic arrest deficient 1 like 1. (717 aa) |
| | CCNE1 | G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin E subfamily. (407 aa) |
| | MAD2L2 | Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also play a role in signal transduction in response to DNA damage. May regulate the activation of the [...] (211 aa) |
| | HDAC8 | Hist_deacetyl domain-containing protein. (368 aa) |
| | CDC14A | Uncharacterized protein. (603 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (929 aa) |
| | CDC7 | Cell division cycle 7. (564 aa) |
| | PLK1 | Serine/threonine-protein kinase PLK. (595 aa) |
| | BUB1 | Uncharacterized protein. (1087 aa) |
| | ORC2 | Uncharacterized protein. (569 aa) |
| | DBF4 | DBF4 zinc finger. (709 aa) |
| | CDK6 | Cyclin-dependent kinase; Belongs to the protein kinase superfamily. (326 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (483 aa) |
| | CDC20 | WD_REPEATS_REGION domain-containing protein. (507 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (867 aa) |
| | CCNA2 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. (395 aa) |
