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ENTPD4 ENTPD4 AMPD1 AMPD1 NME4 NME4 ITPA ITPA ADA ADA PDE6G PDE6G NT5M NT5M PRPS1L1 PRPS1L1 ADK ADK GUCY1B4 GUCY1B4 LOC769866 LOC769866 AMPD3 AMPD3 DGUOK DGUOK HPRT1 HPRT1 PDE6C PDE6C FHIT FHIT ADCY9 ADCY9 NT5C2 NT5C2 XDH XDH LOC101747367 LOC101747367 ENTPD8 ENTPD8 LOC427778 LOC427778 ENTPD8L ENTPD8L ENTPD5 ENTPD5 GMPS GMPS PAPSS1 PAPSS1 ADSS ADSS NUDT9 NUDT9 PGM1 PGM1 AK4 AK4 AK7 AK7 PDE4B PDE4B ADSS1 ADSS1 CANT1 CANT1 GUCY2C GUCY2C PDE5A PDE5A ADSL ADSL ADCY2 ADCY2 PPAT PPAT NUDT5 NUDT5 AK9 AK9 NT5E NT5E PDE9A PDE9A RRM2 RRM2 NT5C1B NT5C1B PRPS2 PRPS2 ADCY3 ADCY3 GUCY1A2 GUCY1A2 RRM1 RRM1 AK6 AK6 PDE6B PDE6B NME2 NME2 PDE3A PDE3A PDE8B PDE8B PDE3B PDE3B DCK DCK GMPR2 GMPR2 PDE6H PDE6H GART-B GART-B APRT APRT PGM2 PGM2 ADCY6-2 ADCY6-2 PAPSS2 PAPSS2 GUCY1A1 GUCY1A1 PDE6D PDE6D PDE11A PDE11A AMPD2 AMPD2 GART GART PKLR PKLR GUCY1B1 GUCY1B1 RRM2B RRM2B NME6 NME6 NT5C3A NT5C3A ADCY1 ADCY1 PDE4D PDE4D AK3 AK3 PRUNE1 PRUNE1 IMPDH2 IMPDH2 ENPP1 ENPP1 AK8 AK8 ENTPD3 ENTPD3 ENPP3 ENPP3 ENTPD1 ENTPD1 GUK1 GUK1 PNP PNP ENPP4 ENPP4 ENTPD6 ENTPD6 HDDC3 HDDC3 ATIC ATIC ENTPD2 ENTPD2 NME3 NME3 PDE7B PDE7B NUDT2 NUDT2 ADPRM ADPRM AK5 AK5 AK1 AK1 ADCY7 ADCY7 NT5C1A NT5C1A NPR2 NPR2 NME7 NME7 LOC107055115 LOC107055115 PDE4C PDE4C PDE10A PDE10A LOC770392 LOC770392 ADCY10L11 ADCY10L11 GDA GDA PDE1C PDE1C PDE1B PDE1B PDE1A PDE1A NTPCR NTPCR ADCY6 ADCY6 CECR1 CECR1 PAICS PAICS ENSGALP00000072814 ENSGALP00000072814 NT5C3B NT5C3B URAH URAH
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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co-expression
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ENTPD4Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (616 aa)
AMPD1AMP deaminase 1; AMP deaminase plays a critical role in energy metabolism; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (707 aa)
NME4Nucleoside diphosphate kinase. (186 aa)
ITPAInosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (201 aa)
ADAAdenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (357 aa)
PDE6GPhosphodiesterase 6 gamma subunit rod form. (87 aa)
NT5M5',3'-nucleotidase, mitochondrial. (230 aa)
PRPS1L1Pribosyltran_N domain-containing protein. (318 aa)
ADKPfkB domain-containing protein. (359 aa)
GUCY1B4Guanylate cyclase domain-containing protein; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (732 aa)
LOC769866Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (208 aa)
AMPD3AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (765 aa)
DGUOKDeoxyadenosine kinase. (265 aa)
HPRT1Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). (330 aa)
PDE6CCone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha; As cone-specific cGMP phosphodiesterase, it plays an essential role in light detection and cone phototransduction by rapidly decreasing intracellular levels of cGMP. (862 aa)
FHITBis(5'-adenosyl)-triphosphatase. (148 aa)
ADCY9Adenylate cyclase type 9; Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors. (1346 aa)
NT5C2Cytosolic purine 5'-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides (By similarity). (598 aa)
XDHXanthine dehydrogenase/oxidase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. (1358 aa)
LOC101747367Uncharacterized protein. (353 aa)
ENTPD8Ectonucleoside triphosphate diphosphohydrolase 8; Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside ATPases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Belongs to the GDA1/CD39 NTPase family. (493 aa)
LOC427778Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (497 aa)
ENTPD8LUncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (416 aa)
ENTPD5Ectonucleoside triphosphate diphosphohydrolase 5; Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thia [...] (443 aa)
GMPSUncharacterized protein. (759 aa)
PAPSS13'-phosphoadenosine 5'-phosphosulfate synthase 1. (624 aa)
ADSSAdenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. (516 aa)
NUDT9Nudix hydrolase 9. (357 aa)
PGM1Uncharacterized protein; Belongs to the phosphohexose mutase family. (562 aa)
AK4Adenylate kinase 4; Belongs to the adenylate kinase family. (171 aa)
AK7Adenylate kinase 7. (715 aa)
PDE4BPhosphodiesterase. (563 aa)
ADSS1Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa)
CANT1Uncharacterized protein. (408 aa)
GUCY2CGuanylate cyclase. (1072 aa)
PDE5APhosphodiesterase. (882 aa)
ADSLAdenylosuccinate lyase; Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (485 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1101 aa)
PPATAmidophosphoribosyltransferase. (510 aa)
NUDT5Nudix hydrolase domain-containing protein; Belongs to the Nudix hydrolase family. (220 aa)
AK9Uncharacterized protein. (1077 aa)
NT5E5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (561 aa)
PDE9APhosphodiesterase. (518 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (384 aa)
NT5C1BUncharacterized protein. (357 aa)
PRPS2Ribose-phosphate pyrophosphokinase 2; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis; Belongs to the ribose-phosphate pyrophosphokinase family. (475 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1127 aa)
GUCY1A2Guanylate cyclase 1 soluble subunit alpha 2; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (724 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (790 aa)
AK6Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (171 aa)
PDE6BPhosphodiesterase. (836 aa)
NME2Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). (153 aa)
PDE3APhosphodiesterase. (850 aa)
PDE8BPhosphodiesterase. (876 aa)
PDE3BPhosphodiesterase. (1105 aa)
DCKdNK domain-containing protein. (216 aa)
GMPR2GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (345 aa)
PDE6HPhosphodiesterase 6 gamma subunit cone form. (85 aa)
GART-BTrifunctional purine biosynthetic protein adenosine-3; In the C-terminal section; belongs to the GART family. In the central section; belongs to the AIR synthase family. (863 aa)
APRTPribosyltran domain-containing protein. (179 aa)
PGM2Uncharacterized protein. (609 aa)
ADCY6-2Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1217 aa)
PAPSS23'-phosphoadenosine 5'-phosphosulfate synthase 2. (601 aa)
GUCY1A1Guanylate cyclase 1 soluble subunit alpha 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (688 aa)
PDE6DRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta; Promotes the release of prenylated target proteins from cellular membranes. Modulates the activity of prenylated or palmitoylated Ras family members by regulating their subcellular location. Required for normal ciliary targeting of farnesylated target proteins, such as INPP5E. Modulates the subcellular location of target proteins by acting as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude. Stabilizes ARL3-GTP by decreasing the nucleotide [...] (150 aa)
PDE11APhosphodiesterase. (886 aa)
AMPD2AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (941 aa)
GARTTrifunctional purine biosynthetic protein adenosine-3; In the central section; belongs to the AIR synthase family. (1003 aa)
PKLRPyruvate kinase PKM; Plays a key role in glycolysis; Belongs to the pyruvate kinase family. (550 aa)
GUCY1B1Guanylate cyclase 1 soluble subunit beta 1; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (701 aa)
RRM2BRibonucleotide reductase regulatory TP53 inducible subunit M2B. (353 aa)
NME6Nucleoside diphosphate kinase. (186 aa)
NT5C3ACytosolic 5'-nucleotidase 3A; Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate. (331 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1098 aa)
PDE4DPhosphodiesterase. (684 aa)
AK3GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (234 aa)
PRUNE1Prune exopolyphosphatase 1. (521 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (538 aa)
ENPP1Uncharacterized protein. (354 aa)
AK8Uncharacterized protein; Belongs to the adenylate kinase family. (453 aa)
ENTPD3Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (511 aa)
ENPP3Ectonucleotide pyrophosphatase/phosphodiesterase 3. (886 aa)
ENTPD1Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (525 aa)
GUK1Guanylate kinase 1. (237 aa)
PNPPurine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (294 aa)
ENPP4Uncharacterized protein. (453 aa)
ENTPD6Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (430 aa)
HDDC3HD domain containing 3. (185 aa)
ATICPhosphoribosylaminoimidazolecarboxamide formyltransferase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis. (593 aa)
ENTPD2Ectonucleoside triphosphate diphosphohydrolase 2; In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent (By similarity). (536 aa)
NME3Nucleoside diphosphate kinase. (206 aa)
PDE7BPhosphodiesterase. (499 aa)
NUDT2Nudix hydrolase 2. (148 aa)
ADPRMADP-ribose/CDP-alcohol diphosphatase, manganese dependent. (373 aa)
AK5Adenylate kinase 5; Belongs to the adenylate kinase family. (594 aa)
AK1Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (194 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
NT5C1A5'-nucleotidase, cytosolic IA. (429 aa)
NPR2Guanylate cyclase. (1097 aa)
NME7Nucleoside diphosphate kinase 7; Belongs to the NDK family. (377 aa)
LOC107055115Guanylate cyclase. (1177 aa)
PDE4CPhosphodiesterase. (724 aa)
PDE10APhosphodiesterase. (1063 aa)
LOC770392Uncharacterized protein. (315 aa)
ADCY10L11Uncharacterized protein. (298 aa)
GDAGuanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (450 aa)
PDE1CPhosphodiesterase. (767 aa)
PDE1BPhosphodiesterase 1B; Belongs to the cyclic nucleotide phosphodiesterase family. (624 aa)
PDE1APhosphodiesterase. (623 aa)
NTPCRNucleoside-triphosphatase. (190 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1132 aa)
CECR1A_deaminase domain-containing protein. (521 aa)
PAICSPhosphoribosylaminoimidazole-succinocarboxamide synthase; In the C-terminal section; belongs to the AIR carboxylase family. Class II subfamily. (1042 aa)
ENSGALP00000072814AIRS_C domain-containing protein. (316 aa)
NT5C3B7-methylguanosine phosphate-specific 5'-nucleotidase; Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates (By similarity); Belongs to the pyrimidine 5'-nucleotidase family. (518 aa)
URAHTR_THY domain-containing protein. (213 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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