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AFMID AFMID CYP1A2 CYP1A2 AANAT AANAT ALDH9A1 ALDH9A1 CCBL1 CCBL1 ALDH3A2 ALDH3A2 KMO KMO AOX1 AOX1 AOX2 AOX2 ALDH7A1 ALDH7A1 AADAT AADAT HAAO HAAO ACAT2 ACAT2 KYNU KYNU DDC DDC ALDH8A1 ALDH8A1 MAOA MAOA HADHA HADHA ASMT ASMT ACAT1 ACAT1 TPH2 TPH2 CYP1A1 CYP1A1 IDO2 IDO2 TDO2 TDO2 DLD DLD CYP1B1 CYP1B1 AOC1 AOC1 MAOB MAOB DLST DLST KYAT3 KYAT3 HADH HADH TPH1 TPH1 CAT CAT IL4I1 IL4I1 ACMSD ACMSD EHHADH EHHADH
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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AFMIDKynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (293 aa)
CYP1A2Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa)
AANATSerotonin N-acetyltransferase; Catalyzes the N-acetylation of serotonin into N- acetylserotonin; Belongs to the acetyltransferase family. AANAT subfamily. (205 aa)
ALDH9A1Aldehyde dehydrogenase 9 family member A1; Belongs to the aldehyde dehydrogenase family. (579 aa)
CCBL1Aminotran_1_2 domain-containing protein. (426 aa)
ALDH3A2Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (490 aa)
KMOKynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (486 aa)
AOX1Uncharacterized protein. (1328 aa)
AOX2Uncharacterized protein. (1337 aa)
ALDH7A1Aldehyde dehydrogenase 7 family member A1; Belongs to the aldehyde dehydrogenase family. (536 aa)
AADATAminoadipate aminotransferase. (428 aa)
HAAO3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (286 aa)
ACAT2Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
KYNUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (530 aa)
DDCDopa decarboxylase. (485 aa)
ALDH8A1Aldehyde dehydrogenase 8 family member A1; Belongs to the aldehyde dehydrogenase family. (487 aa)
MAOAAmine oxidase. (532 aa)
HADHAUncharacterized protein; Belongs to the enoyl-CoA hydratase/isomerase family. (770 aa)
ASMTAcetylserotonin O-methyltransferase; Catalyzes the transfer of a methyl group onto N- acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine). Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. (346 aa)
ACAT1Uncharacterized protein; Belongs to the thiolase-like superfamily. Thiolase family. (421 aa)
TPH2Neuronal tryptophan hydroxylase. (489 aa)
CYP1A1Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa)
IDO2Uncharacterized protein. (383 aa)
TDO2Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. (478 aa)
DLDDihydrolipoyl dehydrogenase. (508 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (536 aa)
AOC1Amine oxidase. (841 aa)
MAOBAmine oxidase. (521 aa)
DLSTLipoyl-binding domain-containing protein. (474 aa)
KYAT3Kynurenine aminotransferase 3. (482 aa)
HADHUncharacterized protein. (350 aa)
TPH1Tryptophan 5-hydroxylase 1; Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. (475 aa)
CATCatalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (528 aa)
IL4I1Amine oxidase. (523 aa)
ACMSD2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). Belongs to the metallo-dependent hydrolases superfamily. (396 aa)
EHHADHEnoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. (726 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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