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CYP1A2 CYP1A2 HSD11B1b HSD11B1b MGST3 MGST3 AKR7L AKR7L UGT1A1 UGT1A1 GSTT1L GSTT1L GSTT1 GSTT1 GSTO2 GSTO2 EPHX1 EPHX1 MGST2 MGST2 EPHX1L EPHX1L HPGDS HPGDS UGT2A1 UGT2A1 ADH4 ADH4 GSTK1 GSTK1 LOC396380 LOC396380 GSTA4 GSTA4 GSTA3 GSTA3 GSTA2 GSTA2 LOC100859645 LOC100859645 ADH6 ADH6 CYP1A1 CYP1A1 LOC395611 LOC395611 GSTM3 GSTM3 CYP1B1 CYP1B1 GSTM2 GSTM2 ADH1C ADH1C CBR3 CBR3 MGST1 MGST1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CYP1A2Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa)
HSD11B1bUncharacterized protein. (301 aa)
MGST3Uncharacterized protein. (142 aa)
AKR7LAldo-keto reductase family 7 like (gene/pseudogene). (326 aa)
UGT1A1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (532 aa)
GSTT1LUncharacterized protein. (242 aa)
GSTT1Glutathione S-transferase theta-1; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Theta family. (261 aa)
GSTO2Uncharacterized protein. (239 aa)
EPHX1Epoxide hydrolase; Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. Belongs to the peptidase S33 family. (464 aa)
MGST2Microsomal glutathione S-transferase 2. (147 aa)
EPHX1LEHN domain-containing protein. (486 aa)
HPGDSHematopoietic prostaglandin D synthase; Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides, organic isothiocyanates and alpha,beta-unsaturated carbonyls. Also exhibits low glutathione-peroxidase activity towards cumene hydroperoxide and t-butyl hydroperoxide. (199 aa)
UGT2A1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
ADH4S-(hydroxymethyl)glutathione dehydrogenase; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (374 aa)
GSTK1Glutathione S-transferase kappa. (224 aa)
LOC396380Glutathione S-transferase 3; Catalyzes the conjugation of GSH to a wide variety of electrophilic alkylating agents. Also involved in the metabolism of lipid hydroperoxides, prostaglandins and leukotriene A4 and in binding of non-substrate hydrophobic ligands such as bile acids, a number of drugs and thyroid hormones. This GST does not exhibit peroxidase activity. (229 aa)
GSTA4Glutathione S-transferase class-alpha. (223 aa)
GSTA3Glutathione S-transferase; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. (221 aa)
GSTA2Glutathione S-transferase; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Alpha family. (222 aa)
LOC100859645Uncharacterized protein. (221 aa)
ADH6PKS_ER domain-containing protein. (376 aa)
CYP1A1Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa)
LOC395611Uncharacterized protein; Belongs to the GST superfamily. (221 aa)
GSTM3Glutathione S-transferase. (219 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (536 aa)
GSTM2Glutathione S-transferase 2; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles; Belongs to the GST superfamily. Mu family. (220 aa)
ADH1CAlcohol dehydrogenase 1. (376 aa)
CBR3Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (276 aa)
MGST1Uncharacterized protein. (155 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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