STRINGSTRING
SNRPE SNRPE HNRNPM HNRNPM SRSF3 SRSF3 DDX42 DDX42 SF3A2 SF3A2 SYF2 SYF2 SF3A3 SF3A3 PRPF38B PRPF38B BCAS2 BCAS2 NCBP1 NCBP1 SF3B3 SF3B3 U2SURP U2SURP SNRPC SNRPC PRPF8 PRPF8 LSM4 LSM4 DDX5 DDX5 CHERP CHERP SRSF10 SRSF10 RBM22 RBM22 BUD31 BUD31 PPIH PPIH ISY1 ISY1 LOC422214 LOC422214 PRPF6 PRPF6 RBM17 RBM17 TRA2B TRA2B SNRPD3 SNRPD3 CTNNBL1 CTNNBL1 NCBP2 NCBP2 SNRPA1 SNRPA1 ALYREF ALYREF SF3A1 SF3A1 SF3B1 SF3B1 CRNKL1 CRNKL1 SMNDC1 SMNDC1 PRPF4 PRPF4 LSM8 LSM8 SRSF5 SRSF5 SNW1 SNW1 PRPF38A PRPF38A HNRNPU HNRNPU TRA2A TRA2A WBP11 WBP11 SNU13 SNU13 PHF5A PHF5A HNRNPK HNRNPK SF3B4 SF3B4 SNRNP27 SNRNP27 DHX15 DHX15 CDC40 CDC40 U2AF1 U2AF1 SF3B6 SF3B6 DHX38 DHX38 EIF4A3 EIF4A3 SRSF1 SRSF1 PRPF3 PRPF3 NWD1 NWD1 SNRPB2 SNRPB2 TCERG1 TCERG1 SRSF7 SRSF7 SNRPN SNRPN DHX8 DHX8 SRSF5A SRSF5A SF3B5 SF3B5 PUF60 PUF60 SRSF6 SRSF6 LSM3 LSM3 PPIE PPIE HSPA8 HSPA8 SNRPD1 SNRPD1 THOC2 THOC2 PRPF18 PRPF18 RP9 RP9 DDX23 DDX23 SNRNP200 SNRNP200 SRSF2 SRSF2 ZMAT2 ZMAT2 SRSF7L SRSF7L SLU7 SLU7 HNRNPA3 HNRNPA3 LSM5 LSM5 PRPF19 PRPF19 THOC3 THOC3 PLRG1 PLRG1 THOC1 THOC1 CWC15 CWC15 HNRNPKL HNRNPKL SNRPF SNRPF MAGOH MAGOH RBMXL1 RBMXL1 LSM6 LSM6 EFTUD2 EFTUD2 TXNL4A TXNL4A CDC5L CDC5L CCDC12 CCDC12 SNRPGP15 SNRPGP15 RBM25 RBM25 PPIL1 PPIL1 SNRPD2 SNRPD2 U2AF2 U2AF2 SRSF4 SRSF4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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SNRPESmall nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (92 aa)
HNRNPMUncharacterized protein. (709 aa)
SRSF3RRM domain-containing protein. (164 aa)
DDX42ATP-dependent RNA helicase DDX42; ATP-dependent RNA helicase. Binds to RNA. May be involved in the survival of cells (By similarity). (944 aa)
SF3A2Splicing factor 3a subunit 2. (315 aa)
SYF2Uncharacterized protein. (252 aa)
SF3A3Splicing factor 3a subunit 3. (501 aa)
PRPF38BUncharacterized protein. (549 aa)
BCAS2Uncharacterized protein. (225 aa)
NCBP1Nuclear cap-binding protein subunit 1; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U sn [...] (793 aa)
SF3B3Splicing factor 3b subunit 3. (1217 aa)
U2SURPU2 snRNP associated SURP domain containing. (1048 aa)
SNRPCU1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. (160 aa)
PRPF8Pre-mRNA processing factor 8. (2335 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (138 aa)
DDX5Uncharacterized protein; Belongs to the DEAD box helicase family. (603 aa)
CHERPUncharacterized protein. (1018 aa)
SRSF10RRM domain-containing protein. (262 aa)
RBM22Pre-mRNA-splicing factor RBM22; Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Belongs to the SLT11 family. (420 aa)
BUD31BUD31 homolog. (144 aa)
PPIHPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (177 aa)
ISY1Uncharacterized protein. (280 aa)
LOC422214Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (168 aa)
PRPF6Pre-mRNA processing factor 6. (941 aa)
RBM17RNA binding motif protein 17. (401 aa)
TRA2BTransformer-2 beta. (289 aa)
SNRPD3Small nuclear ribonucleoprotein Sm D3. (126 aa)
CTNNBL1Catenin beta like 1. (563 aa)
NCBP2Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (159 aa)
SNRPA1LRRcap domain-containing protein. (255 aa)
ALYREFRRM domain-containing protein. (255 aa)
SF3A1Uncharacterized protein. (790 aa)
SF3B1Splicing factor 3b subunit 1. (1301 aa)
CRNKL1Crooked neck pre-mRNA splicing factor 1. (686 aa)
SMNDC1Survival motor neuron domain containing 1. (238 aa)
PRPF4Pre-mRNA processing factor 4. (537 aa)
LSM8U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (96 aa)
SRSF5Uncharacterized protein. (264 aa)
SNW1SNW domain containing 1. (538 aa)
PRPF38APRP38_assoc domain-containing protein. (312 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (818 aa)
TRA2ARRM domain-containing protein. (277 aa)
WBP11Uncharacterized protein. (648 aa)
SNU13Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (128 aa)
PHF5AUncharacterized protein. (110 aa)
HNRNPKHeterogeneous nuclear ribonucleoprotein K. (427 aa)
SF3B4Splicing factor 3b subunit 4. (418 aa)
SNRNP27Small nuclear ribonucleoprotein U4/U6.U5 subunit 27. (156 aa)
DHX15Uncharacterized protein. (762 aa)
CDC40WD_REPEATS_REGION domain-containing protein. (580 aa)
U2AF1U2snRNP auxiliary factor small subunit. (237 aa)
SF3B6Splicing factor 3b subunit 6. (91 aa)
DHX38Uncharacterized protein. (1230 aa)
EIF4A3Eukaryotic initiation factor 4A-III; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the [...] (412 aa)
SRSF1Serine/arginine-rich splicing factor 1; May play a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. (248 aa)
PRPF3U4/U6 small nuclear ribonucleoprotein Prp3; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). (684 aa)
NWD1WD_REPEATS_REGION domain-containing protein. (425 aa)
SNRPB2Small nuclear ribonucleoprotein polypeptide B2. (226 aa)
TCERG1Transcription elongation regulator 1. (987 aa)
SRSF7Uncharacterized protein. (238 aa)
SNRPNSmall nuclear ribonucleoprotein-associated protein B; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (By similarity). Is also a component of the minor U12 spliceosome (By similarity). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity). (240 aa)
DHX8DEAH-box helicase 8. (1163 aa)
SRSF5AUncharacterized protein. (278 aa)
SF3B5Splicing factor 3B subunit 5; Belongs to the SF3B5 family. (86 aa)
PUF60Uncharacterized protein. (364 aa)
SRSF6Uncharacterized protein. (351 aa)
LSM3Uncharacterized protein. (102 aa)
PPIEPeptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (321 aa)
HSPA8Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] (638 aa)
SNRPD1Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family. (119 aa)
THOC2THO complex 2. (1505 aa)
PRPF18SFM domain-containing protein. (351 aa)
RP9Uncharacterized protein. (228 aa)
DDX23DEAD-box helicase 23. (816 aa)
SNRNP200Helicase_PWI domain-containing protein. (614 aa)
SRSF2Serine/arginine-rich splicing factor 2; Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. (221 aa)
ZMAT2U1-type domain-containing protein. (199 aa)
SRSF7LUncharacterized protein. (250 aa)
SLU7Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. (671 aa)
HNRNPA3Heterogeneous nuclear ribonucleoprotein A3. (386 aa)
LSM5U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. (91 aa)
PRPF19Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity; Belongs to the WD repeat PRP19 family. (504 aa)
THOC3WD_REPEATS_REGION domain-containing protein. (381 aa)
PLRG1Pleiotropic regulator 1. (516 aa)
THOC1Death domain-containing protein. (671 aa)
CWC15Uncharacterized protein. (230 aa)
HNRNPKLHeterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. May play an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression (By similarity). (428 aa)
SNRPFSm domain-containing protein. (86 aa)
MAGOHProtein mago nashi homolog; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby infl [...] (154 aa)
RBMXL1RRM domain-containing protein. (385 aa)
LSM6Sm domain-containing protein. (80 aa)
EFTUD2116 kDa U5 small nuclear ribonucleoprotein component; Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (By similarity). Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (By similarity). (1222 aa)
TXNL4AThioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (142 aa)
CDC5LCell division cycle 5 like. (1410 aa)
CCDC12Uncharacterized protein. (207 aa)
SNRPGP15Small nuclear ribonucleoprotein G. (76 aa)
RBM25RRM domain-containing protein. (433 aa)
PPIL1Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (298 aa)
SNRPD2Small nuclear ribonucleoprotein Sm D2. (146 aa)
U2AF2U2 small nuclear RNA auxiliary factor 2. (699 aa)
SRSF4Serine and arginine rich splicing factor 4. (475 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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