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SNRPE | Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (92 aa) | ||||
HNRNPM | Uncharacterized protein. (709 aa) | ||||
SRSF3 | RRM domain-containing protein. (164 aa) | ||||
DDX42 | ATP-dependent RNA helicase DDX42; ATP-dependent RNA helicase. Binds to RNA. May be involved in the survival of cells (By similarity). (944 aa) | ||||
SF3A2 | Splicing factor 3a subunit 2. (315 aa) | ||||
SYF2 | Uncharacterized protein. (252 aa) | ||||
SF3A3 | Splicing factor 3a subunit 3. (501 aa) | ||||
PRPF38B | Uncharacterized protein. (549 aa) | ||||
BCAS2 | Uncharacterized protein. (225 aa) | ||||
NCBP1 | Nuclear cap-binding protein subunit 1; Component of the cap-binding complex (CBC), which binds cotranscriptionally to the 5'-cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5'-end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U sn [...] (793 aa) | ||||
SF3B3 | Splicing factor 3b subunit 3. (1217 aa) | ||||
U2SURP | U2 snRNP associated SURP domain containing. (1048 aa) | ||||
SNRPC | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. (160 aa) | ||||
PRPF8 | Pre-mRNA processing factor 8. (2335 aa) | ||||
LSM4 | U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (138 aa) | ||||
DDX5 | Uncharacterized protein; Belongs to the DEAD box helicase family. (603 aa) | ||||
CHERP | Uncharacterized protein. (1018 aa) | ||||
SRSF10 | RRM domain-containing protein. (262 aa) | ||||
RBM22 | Pre-mRNA-splicing factor RBM22; Required for pre-mRNA splicing as component of the activated spliceosome. Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Belongs to the SLT11 family. (420 aa) | ||||
BUD31 | BUD31 homolog. (144 aa) | ||||
PPIH | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (177 aa) | ||||
ISY1 | Uncharacterized protein. (280 aa) | ||||
LOC422214 | Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (168 aa) | ||||
PRPF6 | Pre-mRNA processing factor 6. (941 aa) | ||||
RBM17 | RNA binding motif protein 17. (401 aa) | ||||
TRA2B | Transformer-2 beta. (289 aa) | ||||
SNRPD3 | Small nuclear ribonucleoprotein Sm D3. (126 aa) | ||||
CTNNBL1 | Catenin beta like 1. (563 aa) | ||||
NCBP2 | Nuclear cap-binding protein subunit 2; Component of the cap-binding complex (CBC), which binds co- transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense- mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U [...] (159 aa) | ||||
SNRPA1 | LRRcap domain-containing protein. (255 aa) | ||||
ALYREF | RRM domain-containing protein. (255 aa) | ||||
SF3A1 | Uncharacterized protein. (790 aa) | ||||
SF3B1 | Splicing factor 3b subunit 1. (1301 aa) | ||||
CRNKL1 | Crooked neck pre-mRNA splicing factor 1. (686 aa) | ||||
SMNDC1 | Survival motor neuron domain containing 1. (238 aa) | ||||
PRPF4 | Pre-mRNA processing factor 4. (537 aa) | ||||
LSM8 | U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (96 aa) | ||||
SRSF5 | Uncharacterized protein. (264 aa) | ||||
SNW1 | SNW domain containing 1. (538 aa) | ||||
PRPF38A | PRP38_assoc domain-containing protein. (312 aa) | ||||
HNRNPU | Heterogeneous nuclear ribonucleoprotein U. (818 aa) | ||||
TRA2A | RRM domain-containing protein. (277 aa) | ||||
WBP11 | Uncharacterized protein. (648 aa) | ||||
SNU13 | Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (128 aa) | ||||
PHF5A | Uncharacterized protein. (110 aa) | ||||
HNRNPK | Heterogeneous nuclear ribonucleoprotein K. (427 aa) | ||||
SF3B4 | Splicing factor 3b subunit 4. (418 aa) | ||||
SNRNP27 | Small nuclear ribonucleoprotein U4/U6.U5 subunit 27. (156 aa) | ||||
DHX15 | Uncharacterized protein. (762 aa) | ||||
CDC40 | WD_REPEATS_REGION domain-containing protein. (580 aa) | ||||
U2AF1 | U2snRNP auxiliary factor small subunit. (237 aa) | ||||
SF3B6 | Splicing factor 3b subunit 6. (91 aa) | ||||
DHX38 | Uncharacterized protein. (1230 aa) | ||||
EIF4A3 | Eukaryotic initiation factor 4A-III; ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the [...] (412 aa) | ||||
SRSF1 | Serine/arginine-rich splicing factor 1; May play a role in preventing exon skipping, ensuring the accuracy of splicing and regulating alternative splicing. (248 aa) | ||||
PRPF3 | U4/U6 small nuclear ribonucleoprotein Prp3; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). (684 aa) | ||||
NWD1 | WD_REPEATS_REGION domain-containing protein. (425 aa) | ||||
SNRPB2 | Small nuclear ribonucleoprotein polypeptide B2. (226 aa) | ||||
TCERG1 | Transcription elongation regulator 1. (987 aa) | ||||
SRSF7 | Uncharacterized protein. (238 aa) | ||||
SNRPN | Small nuclear ribonucleoprotein-associated protein B; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (By similarity). Is also a component of the minor U12 spliceosome (By similarity). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity). (240 aa) | ||||
DHX8 | DEAH-box helicase 8. (1163 aa) | ||||
SRSF5A | Uncharacterized protein. (278 aa) | ||||
SF3B5 | Splicing factor 3B subunit 5; Belongs to the SF3B5 family. (86 aa) | ||||
PUF60 | Uncharacterized protein. (364 aa) | ||||
SRSF6 | Uncharacterized protein. (351 aa) | ||||
LSM3 | Uncharacterized protein. (102 aa) | ||||
PPIE | Peptidyl-prolyl cis-trans isomerase E; Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins; Belongs to the cyclophilin-type PPIase family. PPIase E subfamily. (321 aa) | ||||
HSPA8 | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] (638 aa) | ||||
SNRPD1 | Small nuclear ribonucleoprotein Sm D1; Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures. Belongs to the snRNP core protein family. (119 aa) | ||||
THOC2 | THO complex 2. (1505 aa) | ||||
PRPF18 | SFM domain-containing protein. (351 aa) | ||||
RP9 | Uncharacterized protein. (228 aa) | ||||
DDX23 | DEAD-box helicase 23. (816 aa) | ||||
SNRNP200 | Helicase_PWI domain-containing protein. (614 aa) | ||||
SRSF2 | Serine/arginine-rich splicing factor 2; Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. (221 aa) | ||||
ZMAT2 | U1-type domain-containing protein. (199 aa) | ||||
SRSF7L | Uncharacterized protein. (250 aa) | ||||
SLU7 | Pre-mRNA-splicing factor SLU7; Required for pre-mRNA splicing as component of the spliceosome. Participates in the second catalytic step of pre-mRNA splicing, when the free hydroxyl group of exon I attacks the 3'-splice site to generate spliced mRNA and the excised lariat intron. Required for holding exon 1 properly in the spliceosome and for correct AG identification when more than one possible AG exists in 3'-splicing site region. May be involved in the activation of proximal AG. Probably also involved in alternative splicing regulation. (671 aa) | ||||
HNRNPA3 | Heterogeneous nuclear ribonucleoprotein A3. (386 aa) | ||||
LSM5 | U6 snRNA-associated Sm-like protein LSm5; Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. (91 aa) | ||||
PRPF19 | Pre-mRNA-processing factor 19; Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity; Belongs to the WD repeat PRP19 family. (504 aa) | ||||
THOC3 | WD_REPEATS_REGION domain-containing protein. (381 aa) | ||||
PLRG1 | Pleiotropic regulator 1. (516 aa) | ||||
THOC1 | Death domain-containing protein. (671 aa) | ||||
CWC15 | Uncharacterized protein. (230 aa) | ||||
HNRNPKL | Heterogeneous nuclear ribonucleoprotein K; One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. May play an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression (By similarity). (428 aa) | ||||
SNRPF | Sm domain-containing protein. (86 aa) | ||||
MAGOH | Protein mago nashi homolog; Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby infl [...] (154 aa) | ||||
RBMXL1 | RRM domain-containing protein. (385 aa) | ||||
LSM6 | Sm domain-containing protein. (80 aa) | ||||
EFTUD2 | 116 kDa U5 small nuclear ribonucleoprotein component; Required for pre-mRNA splicing as component of the spliceosome, including pre-catalytic, catalytic and post-catalytic spliceosomal complexes (By similarity). Component of the U5 snRNP and the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome (By similarity). (1222 aa) | ||||
TXNL4A | Thioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (142 aa) | ||||
CDC5L | Cell division cycle 5 like. (1410 aa) | ||||
CCDC12 | Uncharacterized protein. (207 aa) | ||||
SNRPGP15 | Small nuclear ribonucleoprotein G. (76 aa) | ||||
RBM25 | RRM domain-containing protein. (433 aa) | ||||
PPIL1 | Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (298 aa) | ||||
SNRPD2 | Small nuclear ribonucleoprotein Sm D2. (146 aa) | ||||
U2AF2 | U2 small nuclear RNA auxiliary factor 2. (699 aa) | ||||
SRSF4 | Serine and arginine rich splicing factor 4. (475 aa) |