STRINGSTRING
RPA2 RPA2 GTF2H2 GTF2H2 ERCC4 ERCC4 RPA1 RPA1 ERCC6 ERCC6 CETN1 CETN1 POLE POLE DDB2 DDB2 RPA3 RPA3 ERCC3 ERCC3 MNAT1 MNAT1 RBX1 RBX1 RFC1 RFC1 CDK7 CDK7 RAD23B RAD23B CUL4A CUL4A ERCC5 ERCC5 RFC3 RFC3 POLD3 POLD3 GTF2H3 GTF2H3 POLE3 POLE3 XPA XPA RAD23A RAD23A GTF2H5 GTF2H5 CUL4B CUL4B GTF2H1 GTF2H1 DDB1 DDB1 POLE2 POLE2 RFC2 RFC2 RFC5 RFC5 CCNH CCNH RFC4 RFC4 PCNA PCNA LIG1 LIG1 ERCC8 ERCC8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPA2RPA_C domain-containing protein. (267 aa)
GTF2H2General transcription factor IIH subunit. (395 aa)
ERCC4ERCC4 domain-containing protein. (903 aa)
RPA1Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (614 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1495 aa)
CETN1Uncharacterized protein. (172 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2290 aa)
DDB2DNA damage-binding protein 2; Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1- CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1- CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV [...] (507 aa)
RPA3Replication protein A3. (121 aa)
ERCC3General transcription and DNA repair factor IIH helicase subunit XPB; ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required fo [...] (780 aa)
MNAT1CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. (309 aa)
RBX1RING-type domain-containing protein. (108 aa)
RFC1Replication factor C subunit 1. (1147 aa)
CDK7Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (343 aa)
RAD23BRAD23 homolog B, nucleotide excision repair protein. (504 aa)
CUL4ACullin 4A; Belongs to the cullin family. (767 aa)
ERCC5Uncharacterized protein. (1118 aa)
RFC3AAA domain-containing protein. (356 aa)
POLD3DNA polymerase delta subunit 3; Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex. As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA. Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences [...] (467 aa)
GTF2H3Uncharacterized protein. (307 aa)
POLE3CBFD_NFYB_HMF domain-containing protein. (143 aa)
XPADNA repair protein complementing XP-A cells homolog; Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region (By similarity). Belongs to the XPA family. (270 aa)
RAD23ARAD23 homolog A, nucleotide excision repair protein. (362 aa)
GTF2H5General transcription factor IIH subunit 5; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] (71 aa)
CUL4BCullin 4B; Belongs to the cullin family. (883 aa)
GTF2H1Uncharacterized protein. (548 aa)
DDB1DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (By similarity). Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein li [...] (1139 aa)
POLE2DNA polymerase epsilon subunit 2; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). (555 aa)
RFC2Replication factor C subunit 2; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity). (359 aa)
RFC5Replication factor C subunit 5. (392 aa)
CCNHCyclin H; Belongs to the cyclin family. (322 aa)
RFC4AAA domain-containing protein. (362 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
LIG1DNA ligase 1; Belongs to the ATP-dependent DNA ligase family. (961 aa)
ERCC8ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (399 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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