(19 nodes) Mismatch repair network (Gallus gallus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	RPA2	RPA_C domain-containing protein. (267 aa)
	RPA1	Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (614 aa)
	PMS2	Mismatch repair endonuclease PMS2; Component of the post-replicative DNA mismatch repair system (MMR). Involved in B cell growth by positively regulating B cell proliferation and controlling replication efficiency. Controls cell cycle to prevent re-replication and defects in DNA damage-induced G2 checkpoint. Doesn't seem to counteract or control the immunoglobulin gene conversion (Ig GC) and to contribute to guanine/uracil mismatch repair. (869 aa)
	MSH2	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (942 aa)
	MLH3	MutL homolog 3. (1446 aa)
	RPA3	Replication protein A3. (121 aa)
	EXO1	Uncharacterized protein. (800 aa)
	SSBP1	Uncharacterized protein. (149 aa)
	RFC1	Replication factor C subunit 1. (1147 aa)
	MSH3	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1090 aa)
	RFC3	AAA domain-containing protein. (356 aa)
	POLD3	DNA polymerase delta subunit 3; Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex. As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA. Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences [...] (467 aa)
	MSH6	DNA mismatch repair protein Msh6; Component of the post-replicative DNA mismatch repair system (MMR). Involved in B cell growth by positively regulating B cell proliferation and controlling replication efficiency. Controls cell cycle to prevent re-replication and defects in DNA damage-induced G2 checkpoint. Doesn't seem to counteract or control the immunoglobulin gene conversion (Ig GC) and to contribute to guanine/uracil mismatch repair. (1342 aa)
	MLH1	DNA mismatch repair protein MLH1. (757 aa)
	RFC2	Replication factor C subunit 2; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity). (359 aa)
	RFC5	Replication factor C subunit 5. (392 aa)
	RFC4	AAA domain-containing protein. (362 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
	LIG1	DNA ligase 1; Belongs to the ATP-dependent DNA ligase family. (961 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EXO1	LIG1	ENSGALP00000017465	ENSGALP00000068796	Uncharacterized protein.	DNA ligase 1; Belongs to the ATP-dependent DNA ligase family.	0.898
EXO1	MLH1	ENSGALP00000017465	ENSGALP00000046377	Uncharacterized protein.	DNA mismatch repair protein MLH1.	0.991
EXO1	MLH3	ENSGALP00000017465	ENSGALP00000016744	Uncharacterized protein.	MutL homolog 3.	0.753
EXO1	MSH2	ENSGALP00000017465	ENSGALP00000014557	Uncharacterized protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.992
EXO1	MSH3	ENSGALP00000017465	ENSGALP00000025089	Uncharacterized protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.959
EXO1	MSH6	ENSGALP00000017465	ENSGALP00000038835	Uncharacterized protein.	DNA mismatch repair protein Msh6; Component of the post-replicative DNA mismatch repair system (MMR). Involved in B cell growth by positively regulating B cell proliferation and controlling replication efficiency. Controls cell cycle to prevent re-replication and defects in DNA damage-induced G2 checkpoint. Doesn't seem to counteract or control the immunoglobulin gene conversion (Ig GC) and to contribute to guanine/uracil mismatch repair.	0.993
EXO1	PCNA	ENSGALP00000017465	ENSGALP00000064149	Uncharacterized protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.927
EXO1	PMS2	ENSGALP00000017465	ENSGALP00000005417	Uncharacterized protein.	Mismatch repair endonuclease PMS2; Component of the post-replicative DNA mismatch repair system (MMR). Involved in B cell growth by positively regulating B cell proliferation and controlling replication efficiency. Controls cell cycle to prevent re-replication and defects in DNA damage-induced G2 checkpoint. Doesn't seem to counteract or control the immunoglobulin gene conversion (Ig GC) and to contribute to guanine/uracil mismatch repair.	0.990
EXO1	POLD3	ENSGALP00000017465	ENSGALP00000027913	Uncharacterized protein.	DNA polymerase delta subunit 3; Accessory component of both the DNA polymerase delta complex and the DNA polymerase zeta complex. As a component of the trimeric and tetrameric DNA polymerase delta complexes (Pol-delta3 and Pol-delta4, respectively), plays a role in high fidelity genome replication, including in lagging strand synthesis, and repair. Required for optimal Pol-delta activity. Stabilizes the Pol-delta complex and plays a major role in Pol-delta stimulation by PCNA. Pol-delta3 and Pol-delta4 are characterized by the absence or the presence of POLD4. They exhibit differences [...]	0.503
EXO1	RFC1	ENSGALP00000017465	ENSGALP00000023075	Uncharacterized protein.	Replication factor C subunit 1.	0.743
EXO1	RFC2	ENSGALP00000017465	ENSGALP00000052755	Uncharacterized protein.	Replication factor C subunit 2; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity).	0.814
EXO1	RFC3	ENSGALP00000017465	ENSGALP00000027512	Uncharacterized protein.	AAA domain-containing protein.	0.864
EXO1	RFC4	ENSGALP00000017465	ENSGALP00000062419	Uncharacterized protein.	AAA domain-containing protein.	0.866
EXO1	RFC5	ENSGALP00000017465	ENSGALP00000059782	Uncharacterized protein.	Replication factor C subunit 5.	0.710
EXO1	RPA1	ENSGALP00000017465	ENSGALP00000004840	Uncharacterized protein.	Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.878
EXO1	RPA2	ENSGALP00000017465	ENSGALP00000001048	Uncharacterized protein.	RPA_C domain-containing protein.	0.730
EXO1	RPA3	ENSGALP00000017465	ENSGALP00000017383	Uncharacterized protein.	Replication protein A3.	0.761
EXO1	SSBP1	ENSGALP00000017465	ENSGALP00000020973	Uncharacterized protein.	Uncharacterized protein.	0.718
LIG1	EXO1	ENSGALP00000068796	ENSGALP00000017465	DNA ligase 1; Belongs to the ATP-dependent DNA ligase family.	Uncharacterized protein.	0.898
LIG1	MLH1	ENSGALP00000068796	ENSGALP00000046377	DNA ligase 1; Belongs to the ATP-dependent DNA ligase family.	DNA mismatch repair protein MLH1.	0.653