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| | CDC27 | Uncharacterized protein. (833 aa) |
| | PTTG2 | Uncharacterized protein. (193 aa) |
| | CDC45 | Cell division cycle 45. (566 aa) |
| | E2F4 | E2F transcription factor 4. (414 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2660 aa) |
| | E2F1 | Transcription factor E2F1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA bindi [...] (403 aa) |
| | CDK1 | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle (By similarity). It is required in higher cells for entry into S-phase and mitosis (By similarity). p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). May play a role in regulating the amplitude of the cyclic expression of circadian clock genes (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (303 aa) |
| | CCND3 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa) |
| | SKP2 | F-box domain-containing protein. (520 aa) |
| | ANAPC7 | Anaphase promoting complex subunit 7. (565 aa) |
| | ABL1 | Tyrosine-protein kinase. (1111 aa) |
| | CCNB1 | G2/mitotic-specific cyclin-B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition. (399 aa) |
| | MAD1L1 | Mitotic arrest deficient 1 like 1. (717 aa) |
| | CCNE1 | G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin E subfamily. (407 aa) |
| | MAD2L2 | Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also play a role in signal transduction in response to DNA damage. May regulate the activation of the [...] (211 aa) |
| | CDC14A | Uncharacterized protein. (603 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (929 aa) |
| | CDC7 | Cell division cycle 7. (564 aa) |
| | PLK1 | Serine/threonine-protein kinase PLK. (595 aa) |
| | SKP1 | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity). (163 aa) |
| | YWHAH | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (247 aa) |
| | CCND1 | G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). (292 aa) |
| | CDC23 | Cell division cycle 23. (595 aa) |
| | BUB1 | Uncharacterized protein. (1087 aa) |
| | ORC2 | Uncharacterized protein. (569 aa) |
| | STAG2 | Stromal antigen 2. (1262 aa) |
| | DBF4 | DBF4 zinc finger. (709 aa) |
| | CDK6 | Cyclin-dependent kinase; Belongs to the protein kinase superfamily. (326 aa) |
| | MDM2 | E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (483 aa) |
| | CDC20 | WD_REPEATS_REGION domain-containing protein. (507 aa) |
| | CDKN2C | Cyclin dependent kinase inhibitor 2C. (167 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (867 aa) |
| | CCNA2 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. (395 aa) |
| | EP300 | E1A binding protein p300. (2450 aa) |
| | RBX1 | RING-type domain-containing protein. (108 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (530 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | WEE2 | Wee1-like protein kinase 2; Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis. Required to maintain meiotic arrest in oocytes by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry (By similarity). (556 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (859 aa) |
| | SMC1B | Structural maintenance of chromosomes protein. (1243 aa) |
| | CDK7 | Cyclin dependent kinase 7; Belongs to the protein kinase superfamily. (343 aa) |
| | ORC3 | ORC_WH_C domain-containing protein. (713 aa) |
| | TTK | TTK protein kinase. (880 aa) |
| | MCM3 | DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (812 aa) |
| | STAG3 | SCD domain-containing protein. (1206 aa) |
| | CDC16 | TPR_REGION domain-containing protein. (623 aa) |
| | TFDP1 | Transcription factor. (411 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (406 aa) |
| | ATM | Non-specific serine/threonine protein kinase. (3050 aa) |
| | CCND2 | G1/S-specific cyclin-D2; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin D subfamily. (291 aa) |
| | YWHAG | 14-3-3 protein gamma; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity); Belongs to the 14-3-3 family. (247 aa) |
| | TGFB2 | Transforming growth factor beta-2 proprotein; Transforming growth factor beta-2 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively. Transforming growth factor beta-2: Multifunctional protein that regulates various processes such as angiogenesis and heart development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi apparatus, Latency-associated peptide (LAP) and Transfor [...] (412 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (825 aa) |
| | FZR1 | WD_REPEATS_REGION domain-containing protein. (493 aa) |
| | CDKN1B | Cyclin-dependent kinase inhibitor p27 Kip1. (198 aa) |
| | E2F3 | E2F transcription factor 3. (341 aa) |
| | TGFB3 | Transforming growth factor beta-3 proprotein; Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively. Transforming growth factor beta-3: Multifunctional protein that regulates embryogenesis and cell differentiation and is required in various processes such as secondary palate development (By similarity). Activation into mature form follows different steps: following cleavage of the proprotein in the Golgi appa [...] (535 aa) |
| | ANAPC5 | Anaphase-promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity). (756 aa) |
| | YWHAE | 14-3-3 protein epsilon; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner; Belongs to the 14-3-3 family. (255 aa) |
| | SFN | 14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa) |
| | GADD45G | Growth arrest and DNA-damage-inducible protein 45 gamma. (159 aa) |
| | GADD45A | Growth arrest and DNA-damage-inducible protein 45 alpha. (157 aa) |
| | WEE1 | Wee1-like protein kinase. (641 aa) |
| | CDKN2B | p15INK4b tumor suppressor. (139 aa) |
| | YWHAB | 14-3-3 protein beta/alpha; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity); Belongs to the 14-3-3 family. (244 aa) |
| | CCNE2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (405 aa) |
| | LOC769000 | Mothers against decapentaplegic homolog. (467 aa) |
| | GADD45B | Growth arrest and DNA damage inducible beta. (169 aa) |
| | STAG1 | SCD domain-containing protein. (997 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (776 aa) |
| | E2F5 | E2F_TDP domain-containing protein. (375 aa) |
| | CHEK2 | Uncharacterized protein. (524 aa) |
| | ANAPC4 | Anaphase promoting complex subunit 4. (838 aa) |
| | YWHAQ | 14-3-3 protein theta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). (245 aa) |
| | ZBTB17 | Zinc finger and BTB domain-containing protein 17; Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrul [...] (817 aa) |
| | ESPL1 | Extra spindle pole bodies like 1, separase. (2222 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (392 aa) |
| | RAD21 | Uncharacterized protein. (633 aa) |
| | CREBBP | CREB binding protein. (2522 aa) |
| | BUB1B | BUB1 N-terminal domain-containing protein. (1086 aa) |
| | TFDP2 | Uncharacterized protein. (508 aa) |
| | SMAD2Z | Mothers against decapentaplegic homolog. (467 aa) |
| | SMC3 | Structural maintenance of chromosomes protein. (1217 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | ANAPC13 | Uncharacterized protein. (74 aa) |
| | HDAC2 | Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). (489 aa) |
| | CDC14B | Uncharacterized protein. (499 aa) |
| | CDC25A | Rhodanese domain-containing protein. (526 aa) |
| | SMAD3 | Mothers against decapentaplegic homolog 3; Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor- regulated SMAD (R-SMAD) (By similarity). (426 aa) |
| | PRKDC | DNA-dependent protein kinase catalytic subunit; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act a [...] (4132 aa) |
| | CCNB3 | G2/mitotic-specific cyclin-B3; Cyclins are positive regulatory subunits of the cyclin- dependent kinases (CDKs), and thereby play an essential role in the control of the cell cycle, notably via their destruction during cell division. Could be involved at the G2/M (mitosis or meiosis) transition. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis. (403 aa) |
| | MAD2L1 | HORMA domain-containing protein. (206 aa) |
| | HDAC1 | Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity); Belongs to the histone deacetylase family. HD type 1 subfamily. (480 aa) |
| | CCNH | Cyclin H; Belongs to the cyclin family. (322 aa) |
| | RBL2 | Uncharacterized protein. (1259 aa) |
| | ANAPC2 | Anaphase promoting complex subunit 2; Belongs to the cullin family. (884 aa) |
| | BUB3 | WD_REPEATS_REGION domain-containing protein. (392 aa) |
| | YWHAZ | 14-3-3 protein zeta; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). (251 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa) |
| | GSK3B | Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (554 aa) |
| | ANAPC1 | Anaphase promoting complex subunit 1. (1948 aa) |
| | E2F2 | E2F_TDP domain-containing protein. (117 aa) |
| | CDC25B | Cell division cycle 25B. (555 aa) |
| | RBL1 | RB transcriptional corepressor like 1. (1050 aa) |
| | ANAPC10 | DOC domain-containing protein. (255 aa) |
| | RB1 | Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...] (984 aa) |
| | CDKN1A | Uncharacterized protein. (319 aa) |
| | MYC | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (429 aa) |
| | CDC26 | Uncharacterized protein. (84 aa) |
| | ORC5 | AAA_16 domain-containing protein. (459 aa) |
