STRINGSTRING
GABARAPL2 GABARAPL2 MTOR MTOR WIPI2 WIPI2 MLST8 MLST8 PPP2CA PPP2CA ATG4A ATG4A PPP2CB PPP2CB GABARAPL1 GABARAPL1 ATG3 ATG3 ATG10 ATG10 ATG2B ATG2B ATG5 ATG5 ATG7 ATG7 PIK3R4 PIK3R4 WIPI1 WIPI1 ATG101 ATG101 ATG9A ATG9A ATG9B ATG9B IGBP1 IGBP1 RPTOR RPTOR PIK3C3 PIK3C3 ATG4B ATG4B ATG13 ATG13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GABARAPL2GABA type A receptor associated protein like 2. (178 aa)
MTORSerine/threonine-protein kinase TOR; Belongs to the PI3/PI4-kinase family. (2521 aa)
WIPI2WD repeat domain phosphoinositide-interacting protein 2; Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Involved in an early step of the formation of preautophagosomal structures. (436 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
PPP2CASerine/threonine-protein phosphatase. (309 aa)
ATG4ACysteine protease ATG4A; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE). Has also an activity of delipidating enzyme for the PE-conjugated forms (By similarity); Belongs to the peptidase C54 family. (397 aa)
PPP2CBSerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase; Belongs to the PPP phosphatase family. PP-1 subfamily. (309 aa)
GABARAPL1GABA type A receptor associated protein like 1. (117 aa)
ATG3Autophagy-related protein 3. (313 aa)
ATG10Autophagy related 10. (227 aa)
ATG2BAutophagy related 2B. (2077 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (288 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (709 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1426 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (508 aa)
ATG101Autophagy related 101. (236 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (919 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (771 aa)
IGBP1Uncharacterized protein. (338 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1374 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (944 aa)
ATG4BCysteine protease ATG4B; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE). Has also an activity of delipidating enzyme for the PE-conjugated forms (By similarity). (393 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (540 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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