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DMA DMA ITGB3 ITGB3 MRC2 MRC2 STX12 STX12 ATP6V0D1 ATP6V0D1 SFTPA1 SFTPA1 RILP RILP ATP6V0A2 ATP6V0A2 COMP COMP RAB5C RAB5C CALR3 CALR3 LOC420160 LOC420160 NCF2 NCF2 SEC61A1 SEC61A1 LOC425049 LOC425049 TLR4 TLR4 RAC1 RAC1 ATP6V1G1 ATP6V1G1 HGS HGS TUBB1 TUBB1 TFRC TFRC ITGB2 ITGB2 TUBB4B TUBB4B MMR1L3 MMR1L3 MRC1 MRC1 ATP6AP1 ATP6AP1 PIKFYVE PIKFYVE ATP6V0C ATP6V0C DYNC1I2 DYNC1I2 THBS1 THBS1 DYNC1I1 DYNC1I1 RAB5A RAB5A TUBA4B TUBA4B DYNC1LI1 DYNC1LI1 CTSV CTSV TUBB2B TUBB2B ATP6V1E1 ATP6V1E1 SEC61B SEC61B ATP6V1H ATP6V1H LOC776720 LOC776720 C1R C1R THBS4 THBS4 ITGA2 ITGA2 STX18 STX18 CYBB CYBB TLR1A TLR1A COLEC12 COLEC12 PLA2R1 PLA2R1 NCF1C NCF1C RAB7B RAB7B VAMP3 VAMP3 TUBA8B TUBA8B DYNC1H1 DYNC1H1 MARCO MARCO TUBAL3 TUBAL3 MBL2 MBL2 TUBB2A TUBB2A MMR1L4 MMR1L4 LOC771876 LOC771876 LOC428421 LOC428421 BF2 BF2 ATP6V0E2 ATP6V0E2 NCF4 NCF4 TUBA1A TUBA1A SEC61A2 SEC61A2 ENSGALP00000045024 ENSGALP00000045024 LOC100857858 LOC100857858 BF1 BF1 BLB3 BLB3 CALR CALR TUBA1B TUBA1B TCIRG1 TCIRG1 TUBB TUBB ITGAV ITGAV ITGB5 ITGB5 LOC776816 LOC776816 ATP6V0A1 ATP6V0A1 TUBA8A TUBA8A MHCIA6 MHCIA6 ATP6V1G3 ATP6V1G3 ATP6V0E1 ATP6V0E1 LOC396477 LOC396477 C3 C3 ATP6V1C1 ATP6V1C1 TUBA3E TUBA3E CYBA CYBA ATP6V0A4 ATP6V0A4 TLR2A TLR2A SEC22B SEC22B CANX CANX ATP6V0D2 ATP6V0D2 BLB2 BLB2 EEA1 EEA1 LAMP1 LAMP1 BLB1 BLB1 ITGB1 ITGB1 ATP6V1B2 ATP6V1B2 TUBB6 TUBB6 STX7 STX7 LOC776719 LOC776719 RAB5B RAB5B DYNC2H1 DYNC2H1 NOS1 NOS1 DMB2 DMB2 TUBA4A TUBA4A LOC101748499 LOC101748499 M6PR M6PR SEC61G SEC61G ACTB ACTB ATP6V0B ATP6V0B RAB7A RAB7A ATP6V1D ATP6V1D SFTPA2 SFTPA2 SCARB1 SCARB1 CTSS CTSS COLEC11 COLEC11 BLA BLA ATP6V1C2 ATP6V1C2 CD36 CD36 DYNC1LI2 DYNC1LI2 PIK3C3 PIK3C3 THBS2 THBS2 LPO LPO
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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DMAMHC class II M alpha chain. (263 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (781 aa)
MRC2Mannose receptor C type 2. (1389 aa)
STX12Syntaxin 12; Belongs to the syntaxin family. (272 aa)
ATP6V0D1V-type proton ATPase subunit; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
SFTPA1Lung lectin. (198 aa)
RILPRab interacting lysosomal protein. (400 aa)
ATP6V0A2V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (839 aa)
COMPUncharacterized protein. (777 aa)
RAB5CRas-related protein Rab-5C; Protein transport. Probably involved in vesicular traffic (By similarity). (216 aa)
CALR3Calreticulin. (420 aa)
LOC420160Uncharacterized protein; Belongs to the peptidase C1 family. (336 aa)
NCF2Neutrophil cytosolic factor 2. (516 aa)
SEC61A1SEC61 translocon alpha 1 subunit. (476 aa)
LOC425049Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
RAC1GTPase cRac1A. (192 aa)
ATP6V1G1V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate. (759 aa)
TUBB1Tubulin beta-6 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (446 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Belongs to the peptidase M28 family. M28B subfamily. (776 aa)
ITGB2Integrin beta. (773 aa)
TUBB4BTubulin beta-3 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a role in dorsal root ganglion axon projection towards the spinal cord. (445 aa)
MMR1L3Uncharacterized protein. (1415 aa)
MRC1Uncharacterized protein. (1458 aa)
ATP6AP1Uncharacterized protein. (455 aa)
PIKFYVEPhosphoinositide kinase, FYVE-type zinc finger containing. (2118 aa)
ATP6V0CV-type proton ATPase proteolipid subunit; Proton-conducting pore forming subunit of the membrane integral V0 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (154 aa)
DYNC1I2WD_REPEATS_REGION domain-containing protein. (608 aa)
THBS1Uncharacterized protein. (1175 aa)
DYNC1I1Dynein cytoplasmic 1 intermediate chain 1. (625 aa)
RAB5AUncharacterized protein. (215 aa)
TUBA4BTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
DYNC1LI1Cytoplasmic dynein 1 light intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes (By similarity); Belongs to the dynein light intermediate chain family. (515 aa)
CTSVCathepsin L1 heavy chain; Important for the overall degradation of proteins in lysosomes; Belongs to the peptidase C1 family. (353 aa)
TUBB2BTubulin beta-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (445 aa)
ATP6V1E1Uncharacterized protein. (226 aa)
SEC61BProtein transport protein Sec61 subunit beta; Necessary for protein translocation in the endoplasmic reticulum. (96 aa)
ATP6V1HV-type proton ATPase subunit H; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit H activates ATPase activity of the enzyme and couples ATPase activity to proton flow. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. (480 aa)
LOC776720Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (286 aa)
C1RComplement C1r; Belongs to the peptidase S1 family. (712 aa)
THBS4Uncharacterized protein. (953 aa)
ITGA2Integrin subunit alpha 2; Belongs to the integrin alpha chain family. (1175 aa)
STX18Syntaxin-18_N domain-containing protein. (333 aa)
CYBBFAD-binding FR-type domain-containing protein. (570 aa)
TLR1ATIR domain-containing protein; Belongs to the Toll-like receptor family. (818 aa)
COLEC12Collectin-12; Scavenger receptor that displays several functions associated with host defense. Binds to carbohydrates (By similarity). (892 aa)
PLA2R1Uncharacterized protein. (1459 aa)
NCF1CUncharacterized protein. (388 aa)
RAB7BRAB7B, member RAS oncogene family. (207 aa)
VAMP3V-SNARE coiled-coil homology domain-containing protein. (104 aa)
TUBA8BTubulin alpha-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (446 aa)
DYNC1H1Dynein cytoplasmic 1 heavy chain 1. (4652 aa)
MARCOSRCR domain-containing protein. (476 aa)
TUBAL3Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (459 aa)
MBL2Mannose-binding protein; Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. (254 aa)
TUBB2ATubulin beta-1 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (445 aa)
MMR1L4Uncharacterized protein. (1448 aa)
LOC771876MRC1L-D. (1256 aa)
LOC428421Uncharacterized protein. (1441 aa)
BF2Class I histocompatibility antigen, F10 alpha chain; Involved in the presentation of foreign antigens to the immune system. (355 aa)
ATP6V0E2V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
NCF4Uncharacterized protein. (350 aa)
TUBA1ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
SEC61A2Plug_translocon domain-containing protein. (476 aa)
ENSGALP00000045024Tubulin_C domain-containing protein. (223 aa)
LOC100857858Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
BF1MHC class I antigen alpha chain; Belongs to the MHC class I family. (360 aa)
BLB3Class II histocompatibility antigen, B-L beta chain. (278 aa)
CALRCalreticulin. (416 aa)
TUBA1BTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (466 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (825 aa)
TUBBTubulin beta-7 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (444 aa)
ITGAVIntegrin alpha-V heavy chain; The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase- 2, osteopontin, osteomodulin, prothrombin, thrombospondin, TGFB1 and vWF. They recognize the sequence R-G-D in a wide array of ligands. Alpha-V integrins may play a role in embryo implantation, angiogenesis and wound healing (By similarity). ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling. ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential [...] (1048 aa)
ITGB5Integrin beta; Belongs to the integrin beta chain family. (811 aa)
LOC776816Actin, cytoplasmic 2, N-terminally processed; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. (375 aa)
ATP6V0A1V-type proton ATPase 116 kDa subunit a isoform 1; Required for assembly and activity of the vacuolar ATPase. Potential role in differential targeting and regulation of the enzyme for a specific organelle (By similarity). (863 aa)
TUBA8ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (447 aa)
MHCIA6Ig-like domain-containing protein; Belongs to the MHC class I family. (352 aa)
ATP6V1G3V-type proton ATPase subunit G; Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (118 aa)
ATP6V0E1V-type proton ATPase subunit; Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (81 aa)
LOC396477Hepatic lectin; Hepatic lectin is a membrane receptor protein that recognizes and binds exposed N-acetylglucosamine moieties of plasma glycoproteins, thus mediating their clearance (from the circulation) and endocytosis. (207 aa)
C3Uncharacterized protein. (1794 aa)
ATP6V1C1V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
TUBA3ETubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (449 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (183 aa)
ATP6V0A4V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (842 aa)
TLR2AToll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (955 aa)
SEC22BVesicle-trafficking protein SEC22b; SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER. (215 aa)
CANXUncharacterized protein. (601 aa)
ATP6V0D2V-type proton ATPase subunit d 2; Subunit of the integral membrane V0 complex of vacuolar ATPase. Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells, thus providing most of the energy required for transport processes in the vacuolar system. May play a role in coupling of proton transport and ATP hydrolysis (By similarity); Belongs to the V-ATPase V0D/AC39 subunit family. (351 aa)
BLB2MHC class II beta chain 2. (263 aa)
EEA1Early endosome antigen 1. (1450 aa)
LAMP1Lysosome-associated membrane glycoprotein 1; Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis; Belongs to the LAMP family. (406 aa)
BLB1Ig-like domain-containing protein. (325 aa)
ITGB1Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-1 recognize the proline-hydroxylated sequence G-F-P-G- E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha- 4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha- 11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha- 4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (822 aa)
ATP6V1B2V-type proton ATPase subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells; Belongs to the ATPase alpha/beta chains family. (503 aa)
TUBB6Tubulin beta-5 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
STX7t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family. (258 aa)
LOC776719Uncharacterized protein. (671 aa)
RAB5BRas-related protein Rab-5B; Protein transport. Probably involved in vesicular traffic (By similarity); Belongs to the small GTPase superfamily. Rab family. (215 aa)
DYNC2H1Dynein cytoplasmic 2 heavy chain 1. (4301 aa)
NOS1Nitric oxide synthase; Produces nitric oxide (NO). (1435 aa)
DMB2Ig-like domain-containing protein. (323 aa)
TUBA4ATubulin alpha-5 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (499 aa)
LOC101748499Ig-like domain-containing protein. (278 aa)
M6PRMannose-6-phosphate receptor, cation dependent. (328 aa)
SEC61GUncharacterized protein. (68 aa)
ACTBActin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. (375 aa)
ATP6V0BUncharacterized protein; Belongs to the V-ATPase proteolipid subunit family. (205 aa)
RAB7ARAB7A, member RAS oncogene family. (207 aa)
ATP6V1DUncharacterized protein. (247 aa)
SFTPA2Surfactant protein A. (222 aa)
SCARB1Scavenger receptor class B member 1; Belongs to the CD36 family. (503 aa)
CTSSUncharacterized protein; Belongs to the peptidase C1 family. (508 aa)
COLEC11Collectin-11; Lectin that plays a role in innate immunity, apoptosis and embryogenesis. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope. Primarily recognizes the terminal disaccharide of the glycan. Also recognizes a subset of fucosylated glycans and lipopolysaccharides. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1. Also plays a role in apoptosis [...] (271 aa)
BLAMHC_II_alpha domain-containing protein. (98 aa)
ATP6V1C2V-type proton ATPase subunit C; Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. (382 aa)
CD36Uncharacterized protein; Belongs to the CD36 family. (471 aa)
DYNC1LI2Dynein light intermediate chain; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes. (534 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (944 aa)
THBS2Thrombospondin-2; Adhesive glycoprotein that mediates cell-to-cell and cell-to- matrix interactions; Belongs to the thrombospondin family. (1213 aa)
LPOUncharacterized protein. (790 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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